Methods for preparing catalyst systems with increased productivity
US-2015361192-A1 · Dec 17, 2015 · US
Method of preparing zirconium-89 oxine complex
US12473307B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12473307-B2 |
| Application number | US-202117532083-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 22, 2021 |
| Priority date | Apr 1, 2014 |
| Publication date | Nov 18, 2025 |
| Grant date | Nov 18, 2025 |
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Abstract
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The invention provides a method of preparing a 89 Zr-oxine complex of the formula The invention also provides a method of labeling a cell with the 89 Zr-oxine complex and a method for detecting a biological cell in a subject comprising administering the 89 Zr-oxine complex to the subject.
First claim
Opening claim text (preview).
The invention claimed is: 1 . A method of preparing a 89 Zr-oxine complex of the formula comprising (i) combining a solution of oxine in hydrochloric acid and a solution of 89 ZrCl 4 in hydrochloric acid at a temperature of 16° C. to 26° C., in the presence of a surfactant, which is polysorbate 80, to form a reaction mixture, (ii) adding an alkaline solution to the reaction mixture in an amount effective to neutralize the mixture, thereby forming the 89 Zr-oxine complex, and (iii) extracting the 89 Zr-oxine complex into chloroform to isolate the 89 Zr-oxine complex. 2 . The method of claim 1 , wherein the alkaline solution comprises sodium bicarbonate.
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Electrochemically active labels · CPC title
using radioactive material · CPC title
in a form not provided for by groups A61K51/1206 - A61K51/1296, e.g. cells, cell fragments, viruses, virus capsides, ghosts, red blood cells, viral vectors · CPC title
involving radioactive labelled substances · CPC title
Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium · CPC title
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- What does patent US12473307B2 cover?
- The invention provides a method of preparing a 89 Zr-oxine complex of the formula The invention also provides a method of labeling a cell with the 89 Zr-oxine complex and a method for detecting a biological cell in a subject comprising administering the 89 Zr-oxine complex to the subject.
- Who is the assignee on this patent?
- Us Health
- What technology area does this patent fall under?
- Primary CPC classification C07F7/003. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).