Systems and methods for treatment of fluid overload

Patent metadata

Field	Value
Publication number	US-12472334-B2
Application number	US-202217826326-A
Country	US
Kind code	B2
Filing date	May 27, 2022
Priority date	Nov 1, 2016
Publication date	Nov 18, 2025
Grant date	Nov 18, 2025

Abstract

Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter system includes first and second selectively deployable restriction members each configured to be activated to at least partially occlude the vein within which the catheter is implanted and to thus restrict fluid within a portion of the vein. The catheter system includes an impeller configured to be driven by a motor to induce a low pressure zone between the restriction members by causing blood to be pumped through the catheter when the restriction members occlude the vein.

First claim

What is claimed is:

1 . A method of treating a condition, the method comprising:
navigating a catheter system into a vein of a patient, wherein the catheter system comprises:
an impeller assembly comprising an impeller housing with an impeller therein;
a distal restrictor mounted around at least a portion of a proximal end of an exterior surface of the impeller housing, wherein the distal restrictor is positioned at least partially proximal to the impeller and configured to direct fluid from an upstream side of the restrictor to the impeller; and
a proximal restrictor located on the catheter system proximal to the impeller assembly:
implanting the impeller assembly in a segment of a vein downstream of a confluence of a branch vessel with the vein; placing the proximal restrictor in a second segment of the vein upstream of the confluence; and operating the impeller assembly and/or the proximal restrictor to create a low pressure region in the branch vessel while allowing fluid to flow from the second segment, past the restrictor balloon, through the impeller assembly, and into the first segment of the vein downstream of the confluence.

2 . The method of claim 1 , wherein placing the proximal restrictor comprises deploying a first selectively expandable restrictor.

3 . The method of claim 1 , further comprising deploying a distal restrictor coupled to the catheter system in the segment of the vein downstream of the confluence.

4 . The method of claim 3 , wherein the proximal restrictor and/or the distal restrictor each comprise an inflatable balloon.

5 . The method of claim 1 , wherein the vein includes an internal jugular vein or a subclavian vein.

6 . The method of claim 1 , wherein the branch vessel is a thoracic duct or a right lymphatic duct.

7 . The method of claim 1 , wherein, when the impeller assembly is activated, blood flows from a proximal side of the proximal restrictor and passes between an outer surface of the proximal restriction member and an inner wall of the vein.

8 . The method of claim 7 , wherein the blood flows through a lumen on a distal portion of the catheter and exits the catheter system via openings in an impeller housing of the impeller assembly.

9 . The method of claim 1 , wherein the catheter system has the proximal restrictor as the only restrictor.

10 . The method of claim 1 , wherein the condition is edema and the low pressure region in the branch vessel promotes draining of lymph.

11 . The method of claim 1 , wherein the catheter system further comprises a catheter shaft comprising a proximal inlet opening and a distal outlet opening, wherein the impeller is disposed in close proximity to the inlet opening.

12 . The method of claim 11 , wherein a distance between the inlet opening and the outlet opening is substantially similar to a length of the distal restrictor in an activated state.

13 . The method of claim 1 , wherein a distal end of the impeller is positioned distal of the distal restrictor.

14 . The method of claim 13 , wherein the distal end of the impeller and a distal outlet are axially collocated.

Assignees

• White Swell Medical Ltd

Inventors

• Nitzan Yaacov
• Raz Sagi
• Chen Shani
• Inbar Or

Classifications

• A61M60/861

  Connections or anchorings for connecting or anchoring pumps or pumping devices to parts of the patient's body · CPC title

• A61M60/135

  inside a blood vessel, e.g. using grafting · CPC title

• A61M2230/30

  Blood pressure (A61M2230/04 takes precedence) · CPC title

• A61M2210/12

  Blood circulatory system · CPC title

• A61M2205/8206

  battery-operated · CPC title