Halobacillus trueperi TCI66207 and bacterial lysate thereof and use of bactertal lysate
US-11712413-B2 · Aug 1, 2023 · US
Method for maintaining skin corneum layer completeness, promoting hyaluronic acid production, improving skin cell mitochondrion activity and/ or promoting skin cell proliferation by using bacterial lysate of Halobacillus trueperi TCI66207
US12472139B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12472139-B2 |
| Application number | US-202318334392-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 14, 2023 |
| Priority date | Jul 19, 2019 |
| Publication date | Nov 18, 2025 |
| Grant date | Nov 18, 2025 |
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Abstract
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A method for maintaining skin corneum layer completeness, promoting hyaluronic acid production, improving skin cell mitochondrion activity and/or promoting skin cell proliferation in a subject in need thereof, includes administering to the subject a composition including bacterial lysate of a H. trueperi TCI66207 strain. The Halobacillus trueperi TCI66207 strain is deposited in Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures under an accession number of DSM 33381.
First claim
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What is claimed is: 1 . A method for maintaining skin corneum layer completeness and/or promoting hyaluronic acid production in a subject in need thereof, comprising administering to the subject a composition comprising bacterial lysate of a H. trueperi TC166207 strain, wherein the H. trueperi TC166207 strain is deposited in Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures under an accession number of DSM 33381. 2 . The method according to claim 1 , wherein the bacterial lysate of the H. trueperi TCI66207 strain increases expression of keratin (Keratin14) and/or hyaluronic acid synthase (HAS3) genes. 3 . The method according to claim 1 , wherein the composition is capable of reducing wrinkles of the subject. 4 . The method according to claim 1 , wherein the composition is capable of relieving skin sagging of the subject. 5 . The method according to claim 1 , wherein the composition is a pharmaceutical composition or a cosmetic composition. 6 . A method for improving skin cell mitochondrion activity in a subject in need thereof, comprising administering to the subject a composition comprising bacterial lysate of a H. trueperi TC166207 strain, wherein the H. trueperi TC166207 strain is deposited in Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures under an accession number of DSM 33381. 7 . The method according to claim 6 , wherein the bacterial lysate of the H. trueperi TCI66207 strain increases expression of keratin (Keratin14) and/or hyaluronic acid synthase (HAS3) genes. 8 . The method according to claim 6 , wherein the composition is capable of enhancing water-retention capacity of the subject. 9 . The method according to claim 6 , wherein the composition is a pharmaceutical composition or a cosmetic composition. 10 . A method for promoting skin cell proliferation in a subject in need thereof, comprising administering to the subject a composition comprising bacterial lysate of a H. trueperi TC166207 strain, wherein the H. trueperi TC166207 strain is deposited in Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures under an accession number of DSM 33381. 11 . The method according to claim 10 , wherein the bacterial lysate of the H. trueperi TCI66207 strain increases expression of keratin (Keratin14) and/or hyaluronic acid synthase (HAS3) genes. 12 . The method according to claim 10 , wherein the composition is capable of reducing wrinkles of the subject. 13 . The method according to claim 10 , wherein the composition is capable of relieving skin sagging of the subject. 14 . The method according to claim 10 , wherein the composition is a pharmaceutical composition or a cosmetic composition.
Assignees
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Classifications
- C12N1/205Primary
Bacterial isolates · CPC title
Drugs for dermatological disorders · CPC title
Bacteria or derivatives thereof, e.g. probiotics · CPC title
Anti-ageing preparations · CPC title
Preparations for care of the skin · CPC title
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- What does patent US12472139B2 cover?
- A method for maintaining skin corneum layer completeness, promoting hyaluronic acid production, improving skin cell mitochondrion activity and/or promoting skin cell proliferation in a subject in need thereof, includes administering to the subject a composition including bacterial lysate of a H. trueperi TCI66207 strain. The Halobacillus trueperi TCI66207 strain is deposited in Leibniz Inst…
- Who is the assignee on this patent?
- Tci Co Ltd
- What technology area does this patent fall under?
- Primary CPC classification C12N1/205. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).