ANS assessment systems, kits, and methods

Patent metadata

Field	Value
Publication number	US-12471776-B2
Application number	US-202318543538-A
Country	US
Kind code	B2
Filing date	Dec 18, 2023
Priority date	Aug 10, 2014
Publication date	Nov 18, 2025
Grant date	Nov 18, 2025

Abstract

Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including a head mounted display to monitor one or more physiologic signals from the face or head of the subject is disclosed. A method for analyzing an ocular parameter of the subject to determine a sympathetic and a parasympathetic outflow thereto is disclosed.

First claim

What is claimed is:

1 . A system comprising:
a head mounted display comprising at least one back-facing imaging sensor configured to take a plurality of images of an eye of a subject over a period of time; and a processor that is at least one of comprised in and coupled to the head mounted display, the processor configured:
to receive the plurality of images of the eye of the subject;
to identify and track a position of a plurality of features of an iris of the eye across the plurality of images to produce one or more activity signals characterizing at least one of sympathetic and parasympathetic neural activity in the eye of the subject; and
to analyze the one or more activity signals to determine an effect of a treatment applied to a target site within the subject.

2 . The system of claim 1 , wherein analyzing the one or more activity signals comprises comparing the one or more activity signals with one or more additional activity signals generated by one or more additional monitoring devices separate from the head mounted display.

3 . The system of claim 1 , wherein the treatment applied to the target site utilizes at least one of an ablation system, a neuromodulation device, a neuromodulation implant, an ablation catheter, a focused energy delivery device, a radio frequency ablation system or catheter, a microwave ablation system or catheter, an ultrasound energy delivery system, a high intensity focused ultrasound (HIFU) delivery system or catheter, a cryoablation system or catheter, a chemical ablation system or catheter, a radiosurgical system, an optical ablation system, an infrared ablation system, a laser ablation system, and an MR guided HIFU system.

4 . The system of claim 1 , wherein the processor is further configured to generate, based at least in part on the analysis of the one or more activity signals, an indication of the effect of the treatment applied to the target site.

5 . The system of claim 4 , wherein the indication comprises one of: an indication that only a partial procedure has been performed on the target site; and an indication that a complete procedure has been performed on the target site.

6 . The system of claim 1 , further comprising one or more stimulating devices configured to stimulate the subject at one or more stimulation sites within the subject.

7 . The system of claim 6 , wherein at least one of the one or more stimulating devices comprises at least one of an electrical stimulator, a thermoregulating device, a heating coil, a thermoelectric device, a Peltier device, a tactile stimulating component, and a vibratory stimulating element.

8 . The system of claim 6 , wherein at least one of the one or more stimulating devices is embedded in a treatment system configured to apply the treatment to the target site within the subject.

9 . The system of claim 8 , wherein the treatment applied to the target site within the subject comprises delivery of at least one of a stimulating energy and a chemical agent to (i) the target site within the subject and (ii) at least one of the one or more stimulation sites within the subject.

10 . The system of claim 1 , wherein the head mounted display comprises a shroud, the shroud arranged so as to isolate one or more eyes of the subject from a surrounding environment, when the head mounted display is coupled to the head of the subject.

11 . The system of claim 10 , wherein the shroud comprises at least one of one or more sensors and one or more electrodes, said at least one of the one or more sensors and the one or more electrodes arranged along the shroud so as to bias against one or more skin sites of the subject when the head mounted display is coupled to the head of the subject, and wherein the processor is coupled to said at least one of the one or more sensors and the one or more electrodes.

12 . The system of claim 11 , wherein said at least one of the one or more sensors and the one or more electrodes are arranged along the shroud so as to capture, in conjunction with the processor, at least one of an electroretinogram, an electrooculogram, an electroencephalogram, and an electromyogram from the subject.

13 . The system of claim 1 , wherein the at least one back-facing imaging sensor comprises at least one of a camera, a visible light camera, a near infrared camera, an infrared camera, short wavelength infrared camera, a CMOS imaging sensor, an infrared imaging sensor, a laser speckle imaging sensor, and a coherence tomographic imaging element.

14 . The system of claim 1 , wherein the at least one back-facing image sensor comprises a plurality of back-facing imaging sensors.

15 . The system of claim 1 , wherein the head mounted display comprises one or more optical sensors arranged so as to bias against one or more skin sites of the subject when the head mounted display is coupled to the head of the subject, the processor coupled to the one or more optical sensors and configured to receive at least one of one or more hemodynamic and one or more tissue analyte signals from the one or more optical sensors and to utilize said at least one of the one or more hemodynamic and the one or more tissue analyte signals in determining the effect of the treatment applied to the target site.

16 . The system of claim 15 , wherein at least one of the one or more optical sensors is arranged so as to interface with at least one of a nose, a nasal bridge, a temple region, an ocular region, an ear, an earlobe, and an ear canal of the subject when the head mounted display is coupled to the head of the subject.

17 . The system of claim 1 , further comprising one or more physiologic sensors coupled to a body of the subject to produce one or more physiologic signals, wherein at least one of the one or more physiologic sensors is in wireless communication with the processor to provide the one or more physiologic signals to the processor, the processor being configured to utilize the one or more physiologic signals received from said at least one of the one or more physiologic sensors in determining the effect of the treatment applied to the target site.

18 . The system of claim 17 , wherein the one or more physiologic sensors comprise at least one of an electrophysiologic sensor, a heart-rate sensor, a skin neural activity sensor, a temperature sensor, a thermal gradient sensor, a barometer, an altimeter, an accelerometer, a gyroscope, a humidity sensor, a magnetometer, an inclinometer, an oximeter, a colorimetric monitor, a perfusion sensor, a sweat analyte sensor, a galvanic skin response sensor, an interfacial pressure sensor, a flow sensor, a stretch sensor, and a microphone.

19 . The system of claim 17 , wherein at least one of the one or more physiologic sensors is arranged for placement onto at least one of a perineal region, a perianal region, a pubic region, an inner thigh region, a posterior knee region, a neck, an ear, an ocular region, a breast, an axilla, an elbow, a wrist, a palm, a foot, lips, and an erogenous zone of the subject.

20 . The system of claim 1 , wherein identifying and tracking the position of the plurality of features of the iris of the eye across the plurality of images to produce the one or more activity signals comprises identifying sphincter muscle related movement and dilator muscle related movement of one or more of the plurality of features of the iris of the eye.

Assignees

• Autonomix Medical Inc

Inventors

• Toth Landy
• Schwartz Robert S

Classifications

• A61B5/33

  specially adapted for cooperation with other devices · CPC title

• A61B5/398

  Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG] · CPC title

• A61B5/389

  Electromyography [EMG] · CPC title

• A61N7/02

  Localised ultrasound hyperthermia · CPC title

• A61N1/36014

  External stimulators, e.g. with patch electrodes (external pacemakers A61N1/3625) · CPC title