Closed-loop artificial pancreas device with integrated detection and infusion

Patent metadata

Field	Value
Publication number	US-12465685-B2
Application number	US-201917611575-A
Country	US
Kind code	B2
Filing date	Dec 31, 2019
Priority date	Jul 19, 2019
Publication date	Nov 11, 2025
Grant date	Nov 11, 2025

Abstract

The invention discloses a closed-loop artificial pancreas device with integrated detection and infusion, comprising: infusion unit configured to deliver drugs; program unit comprising input end and output end, and the input end comprises a plurality of electrically connective regions for receiving signals of analyte data in the body fluid, after the output end is electrically connected to the infusion unit, according to the received signals of analyte data in the body fluid, the program unit controls whether the infusion unit delivers drugs; an infusion cannula with conductive area, the infusion cannula is the drug infusion channel; and a plurality of electrodes for detecting analyte data in body fluid, the electrode comprising conductive-area electrode and cannula-wall electrode, the conductive area of the infusion cannula being at least as a conductive-area electrode, and one or more cannula-wall electrodes being located on/in the wall of the infusion cannula.

First claim

The invention claimed is:

1 . A closed-loop artificial pancreas device with integrated detection and infusion, comprising:
an infusion unit configured to deliver drugs, wherein the infusion unit includes a drug storage unit, a metal piece, a piston and a rigid screw, the piston is arranged in the drug storage unit, the metal piece is fixedly connected to the rigid screw and is arranged on the piston; at least one position detector, wherein the metal piece and the at least one position detector interact to a generate electrical or a magnetic signal; a program unit comprising an input end and at least one output end, and the input end comprising a plurality of electrically connective regions for receiving a signal of an analyte data in a body fluid, after the at least one output end is electrically connected to the infusion unit, according to a received signal of the analyte data in the body fluid, the program unit controls whether the infusion unit delivers the drugs; an infusion cannula with at least one conductive area, wherein the infusion cannula is an infusion channel; and a plurality of electrodes for detecting the analyte data in the body fluid, the electrodes comprising at least one conductive-area electrode and a cannula-wall electrode, the at least one conductive area of the infusion cannula being the at least one conductive- area electrode, wherein when the infusion cannula is installed to a working position, the infusion cannula is connected with the infusion unit, the drugs are capable of being injected into a body through the infusion cannula, and the electrodes are electrically connected to the electrically connective regions respectively, inputting signal of the analyte data in the body fluid to the program unit, wherein the infusion cannula includes an infusion steel needle and a hose which is placed on an outer wall surface of the infusion steel needle, and a needle cavity of the infusion steel needle is used for infusion of the drugs, when the drugs are injected through the infusion cannula, the infusion cannula is installed to the working position, the infusion steel needle does not retract, a depth of the hose into a skin is d 1 , while a depth of the infusion steel needle into the skin is d 2 , d 1 ≤ d 2 , and d 1 >0, wherein when the infusion cannula is installed to the working position, the at least one conductive-area electrode and the cannula-wall electrode are directly electrically connected to the electrically connective regions, respectively, wherein the infusion steel needle is the at least one conductive-area electrode, wherein the cannula-wall electrode is located on the outer wall surface of the infusion steel needle.

2 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 1 , wherein:
an outer surface of the infusion cannula is further provided with an electrode lead electrically connected to the cannula-wall electrode, and when the infusion cannula is installed to the working position, the electrode lead and the at least one conductive-area electrode are electrically connected to the electrically connective regions, respectively.

3 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 1 , wherein:
when the infusion cannula is installed to the working position, the cannula-wall electrode located on the outer wall surface of the infusion steel needle is exposed in a subcutaneous tissue fluid or covered in whole or in part by the hose.

4 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 3 , wherein:
when the cannula-wall electrode located on the outer wall surface of the infusion steel needle is covered in whole or in part by the hose, or when the cannula-wall electrode is located on the inner surface of the hose, the hose is a permeable membrane or a semi-permeable membrane.

5 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 1 , wherein:
the infusion cannula comprises a plurality of electrically conductive areas isolated from each other, the at least one conductive-area electrode comprises a plurality of conductive-area electrodes, the plurality of conductive-area electrodes are the plurality of conductive areas of the infusion cannula.

6 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 1 , wherein:
the electrodes include at least one working electrode and at least one auxiliary electrode.

7 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 6 , wherein:
the at least one conductive-area electrode is the at least one working electrode or the at least one auxiliary electrode.

8 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 7 , wherein:
the plurality of electrodes form at least one electrode combination, each of the at least one electrode combination comprises the working electrode and the auxiliary electrode, the program unit chooses the at least one electrode combination to detect the analyte data in the body fluid.

9 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 8 , further comprising:
a remote device, the remote device and the program unit transmitting wireless signals to each other, the program unit transmitting the analyte data in the body fluid or a drug infusion information to the remote device, and the remote device sending a manually selected electrode combination for detection or the drug infusion information to the program unit.

10 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 6 , wherein:
the at least one auxiliary electrode is a counter electrode, or the at least one auxiliary electrode includes the counter electrode and a reference electrode.

11 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 1 , wherein:
the input end is an elastic member, and the elastic member comprises one of or a combination of a conductive strip, an oriented conductive silica gel, a conductive ring and a conductive ball.

12 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 1 , wherein:
the infusion unit includes a plurality of infusion subunits, the at least one output end comprises a plurality of output ends, the plurality of infusion subunits are electrically connected to the output ends, respectively, and the program unit controls each of the infusion subunits delivers the drugs.

13 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 1 , wherein:
the closed-loop artificial pancreas device with integrated detection and infusion also comprises a plurality of parts, the infusion unit and the program unit are arranged in different parts of the plurality of parts, and the different parts are connected by a waterproof plug.

14 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 1 , wherein:
the at least one position detector comprises a plurality of position detectors, the rigid screw is a metal screw, and the metal piece is electrically connected with the metal screw, so that the metal piece and one of the position detectors constitute a capacitor, and a linear movement of the metal piece causes a change in capacitance making the one of the position detectors generate an electrical signal.

15 . The closed-loop artificial pancreas device with integrated detection and infusion of claim 1 , wher

Assignees

• Medtrum Tech Inc

Inventors

• Yang Cuijun

Classifications

• A61M5/172

  electrical or electronic {(A61M5/16804, A61M5/16831 take precedence)} · CPC title

• A61F2/022

  Artificial gland structures using bioreactors (hemodialysis A61M1/16; hemofiltration A61M1/34; other extracorporeal blood treatment A61M1/36) · CPC title

• A61M2205/502

  User interfaces, e.g. screens or keyboards · CPC title

• G16H20/17

  delivered via infusion or injection · CPC title

• A61M5/1454

  spring-actuated, e.g. by a clockwork · CPC title