Methods and reagents for analyzing protein-protein interfaces
US-10948495-B2 · Mar 16, 2021 · US
Ras inhibitors
US12465643B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12465643-B2 |
| Application number | US-202519068133-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 3, 2025 |
| Priority date | Sep 15, 2020 |
| Publication date | Nov 11, 2025 |
| Grant date | Nov 11, 2025 |
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- Title
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- Abstract
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- First independent claim
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Abstract
Official abstract text for this publication.
The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
First claim
Opening claim text (preview).
The invention claimed is: 1 . A compound having the structure of: or a pharmaceutically acceptable salt thereof, wherein at least one hydrogen atom of the compound is replaced by deuterium. 2 . A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient or carrier.
Assignees
Inventors
Classifications
specific for leukemia · CPC title
containing three or more hetero rings · CPC title
Antineoplastic agents · CPC title
in which the condensed systems contains four or more hetero rings · CPC title
in which the condensed system contains four or more hetero rings · CPC title
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Frequently asked questions
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- What does patent US12465643B2 cover?
- The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
- Who is the assignee on this patent?
- Revolution Medicines Inc
- What technology area does this patent fall under?
- Primary CPC classification C07D513/22. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 11 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).