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Production of guaiene and rotundone
US12460233B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12460233-B2 |
| Application number | US-202217936072-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 28, 2022 |
| Priority date | Dec 5, 2017 |
| Publication date | Nov 4, 2025 |
| Grant date | Nov 4, 2025 |
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- Title
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Abstract
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A process for producing rotundone from α-guaiene, in particular by oxidation of the C(3) position, wherein the α-guaiene is produced from a precursor by a sesquiterpene synthase. The sesquiterpene synthase is produced in a microorganism.
First claim
Opening claim text (preview).
The invention claimed is: 1 . A fragrance or flavor ingredient comprising rotundone in an amount of about 10 to about 95 wt. % and ketone 5: 2 . The fragrance or flavor ingredient according to claim 1 , wherein the rotundone is in an amount of about 20 to about 70 wt. %. 3 . The fragrance or flavor ingredient according to claim 1 , wherein the rotundone is in an amount of about 10 to about 50 wt. %. 4 . A process of making the fragrance or flavor ingredient of claim 1 comprising producing the rotundone from α-guaiene is produced from a precursor by a sesquiterpene synthase, wherein the sesquiterpene synthase has a sequence identity with SEQ ID NO: 2, SEQ ID NO: 4, or SEQ ID NO: 6 of at least 70%, and wherein the sesquiterpene synthase is produced in a microorganism. 5 . The process of claim 4 , wherein the sesquiterpene synthase has a sequence identity with SEQ ID NO.: 2, SEQ ID NO.: 4 or SEQ ID NO.: 6 of at least 80%. 6 . The process of claim 4 , wherein the sesquiterpene synthase has a sequence identity with SEQ ID NO.: 2, SEQ ID NO.: 4 or SEQ ID NO.: 6 of at least 90%. 7 . The process of claim 4 , wherein the sesquiterpene synthase has a sequence identity with SEQ ID NO.: 2, SEQ ID NO.: 4 or SEQ ID NO.: 6 of at least 95%. 8 . A consumer product comprising the fragrance or flavor ingredient according to claim 1 . 9 . A method of using the fragrance or flavor ingredient of claim 1 to impart at least one of a peppery or woody aroma. 10 . The fragrance or flavor ingredient according to claim 1 , wherein the weight ratio of rotundone to ketone 5 ranges from about 20:1 to about 1:20. 11 . The fragrance or flavor ingredient according to claim 1 , wherein the weight ratio of rotundone to ketone 5 ranges from about 10:1 to about 2:1. 12 . The fragrance or flavor ingredient according to claim 1 , wherein the weight ratio of rotundone to ketone 5 ranges from about 5:1 to about 3:1.
Assignees
Inventors
Classifications
Lyases (4.) · CPC title
by oxidation (with ozone C07C45/40) · CPC title
Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title
Natural spices, flavouring agents or condiments; Extracts thereof · CPC title
Alicyclic compounds · CPC title
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Frequently asked questions
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- What does patent US12460233B2 cover?
- A process for producing rotundone from α-guaiene, in particular by oxidation of the C(3) position, wherein the α-guaiene is produced from a precursor by a sesquiterpene synthase. The sesquiterpene synthase is produced in a microorganism.
- Who is the assignee on this patent?
- Givaudan Sa
- What technology area does this patent fall under?
- Primary CPC classification C12P7/38. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).