Bioreactor support system

Patent metadata

Field	Value
Publication number	US-12460169-B2
Application number	US-202017617747-A
Country	US
Kind code	B2
Filing date	Jun 17, 2020
Priority date	Jun 24, 2019
Publication date	Nov 4, 2025
Grant date	Nov 4, 2025

Abstract

A bioreactor support system configured to hold a bioreactor bag, comprising: a base module comprising an impeller drive unit; and at least two vessel units of different sizes, which are configured to support and substantially enclose a side wall of a bioreactor bag when a bioreactor bag is provided in the bioreactor support system, wherein the base module and the vessel units comprise mating connection devices such that the vessel units can be connected to one and the same base module and such that the impeller drive unit of the base module can be used to drive an impeller in a bioreactor bag when a bioreactor bag is provided in the bioreactor support system.

First claim

The invention claimed is:

1 . A bioreactor support system configured to hold a bioreactor bag, said bioreactor support system comprising:
a base module comprising an impeller drive unit, at least one circular groove, and at least two vessel unit connection devices; and at least one vessel unit having an essentially cylindrical side wall and at least two base module connection devices; wherein the at least two vessel unit connection devices provide circular locks with the at least two base module connection devices in said at least one circular groove.

2 . The bioreactor support system according to claim 1 , wherein when the at least one vessel unit is connected to the base module the at least one vessel unit and the base module are configured to support a bottom wall and a side wall of a bioreactor bag when a bioreactor bag is provided in the bioreactor support system.

3 . The bioreactor support system according to claim 1 , wherein the impeller drive unit is configured to provide a rotating magnetic field and wherein the base module comprises an impeller connection position where an impeller connector provided in the bioreactor bag can be provided in a position allowing the rotating magnetic field from the impeller drive unit of the base module to drive an impeller of the bioreactor bag.

4 . The bioreactor support system according to claim 3 , wherein the impeller connection position is provided as an opening in the base module, wherein the at least one vessel unit is configured to be connected to an upper side of the base module and the impeller drive unit is provided on an opposite side of the base module and wherein the opening in the base module is configured to receive the impeller connector provided in the bioreactor bag such that the impeller connector can be provided in a position in relation to the impeller drive unit allowing the rotating magnetic field from the impeller drive unit to drive the impeller of the bioreactor bag.

5 . The bioreactor support system according to claim 1 , wherein the at least one vessel unit comprises the essentially cylindrical side wall which comprises a part of the side wall which can pivot outward such that an opening into an interior of the at least one vessel unit is provided for loading the bioreactor bag into the bioreactor support system.

6 . The bioreactor support system according to claim 1 , the at least one vessel unit comprises the essentially cylindrical side wall which is divided into a first side wall part and a second side wall part which each comprise essentially a half cylindrical wall, where the first side wall part comprises the base module connection devices and is configured to be connected to the base module while the second side wall part is pivotally connected to the first side wall part such that the second side wall part can pivot into at least one open position allowing access into an interior of the vessel unit and one closed position in which the first and second side wall parts together form the essentially cylindrical side wall.

7 . The bioreactor support system according to claim 6 , wherein the half cylindrical wall additionally comprises openings for external access to an interior of the at least one vessel unit.

8 . The bioreactor support system according to claim 1 , wherein the at least one vessel unit comprises one or more flexible heater pads on an inner surface of a side wall, the one or more flexible heater pads are configured to heat the bioreactor bag when the bioreactor bag is provided in the bioreactor support system.

9 . The bioreactor support system according to claim 1 , wherein the at least one vessel unit comprises at least one opening in the side wall for allowing access to the bioreactor bag when the bioreactor bag is provided in the bioreactor support system.

10 . The bioreactor support system according to claim 9 , wherein said at least one opening comprises a graduation for indication of different volumes.

11 . The bioreactor support system according to claim 9 , wherein the at least one vessel unit comprises a sensor support provided in connection with at least one opening in the side wall of said at least one vessel unit, wherein the sensor support is attached to the side wall of said at least one vessel unit such that its position can be adjusted along a height of the at least one vessel unit.

12 . A bioreactor system comprising the bioreactor support system according to claim 1 and a bioreactor bag comprising an impeller and an impeller connector.

13 . The bioreactor system according to claim 12 , wherein the impeller comprises a magnet such that it can be rotated by magnetic force and wherein a size of the impeller in the bioreactor bag is adapted to a size of said bioreactor bag.

14 . The bioreactor system according to claim 12 , wherein the impeller connector of the bioreactor bag is configured to be provided in a close position to the impeller drive unit of the base module via an impeller connection position provided in the base module.

Assignees

• Global Life Sciences Solutions Usa Llc

Inventors

• Kini Prasad
• Agnihotry Shashikanth
• Prabhu Manoja

Classifications

• C12M29/10

  Perfusion · CPC title

• C12M29/06

  Nozzles; Sprayers; Spargers; Diffusers (per se B01F23/231, B01J19/26) · CPC title

• C12M23/48 Primary

  Holding appliances; Racks; Supports (holding devices for laboratory apparatus B01L9/00) · CPC title

• C12M23/14 Primary

  Bags · CPC title

• B01F35/43

  Supporting receptacles on frames or stands · CPC title