Method for transforming an essential oil

Patent metadata

Field	Value
Publication number	US-12460153-B2
Application number	US-202017781958-A
Country	US
Kind code	B2
Filing date	Dec 4, 2020
Priority date	Dec 4, 2019
Publication date	Nov 4, 2025
Grant date	Nov 4, 2025

Abstract

The invention relates to a method for transforming an essential oil, an essential oil fraction obtained in said manner, combinations comprising the essential fraction obtained in said manner and an antibiotic or an antifungal, and the use thereof as a medicament, in particular the use thereof in the prevention or treatment of infectious bacterial or fungal diseases.

First claim

The invention claimed is:

1 . A method for transforming an essential oil comprising:
providing a previously extracted essential oil; evaporating a fraction of between 20 and 50% of the essential oil for at least 2 hours, under a pressure less than or equal to 500 mbar and at a temperature between 4° and 100° C.; obtaining a transformed essential oil comprising the recovery of the unevaporated essential oil fraction; and combining said transformed essential oil comprising the recovery of the unevaporated essential oil fraction with at least one antibiotic.

2 . The method of transformation according to claim 1 , wherein the evaporation is between 30 and 50%.

3 . The method of transformation according to claim 1 , wherein the evaporation is undertaken for a duration between 18 and 96 hours.

4 . The method of transformation according to claim 1 , wherein the evaporation is undertaken under a pressure less than or equal to 300 mbar.

5 . The method of transformation according to claim 1 , wherein the evaporation is undertaken at a temperature between 4° and 60° C.

6 . The method of transformation according to claim 1 , wherein the essential oil is previously extracted from French lavender or compact marjoram.

7 . The method of transformation according to claim 1 , wherein the essential oil is previously extracted from French lavender and in that the evaporation is undertaken for a duration between 24 and 96 hours, under a pressure between 25 and 75 mbar and at a temperature between 4° and 60° C.

8 . A combination obtainable by the method of transformation according to claim 1 , said combination comprising said transformed essential oil comprising the recovery of the unevaporated essential oil fraction and at least one antibiotic.

9 . The combination according to claim 8 , further comprising a second essential oil.

10 . The combination according to claim 8 , wherein the essential oil is previously extracted from French lavender and the antibiotic is a penicillin.

11 . In a method of making a medicament using an essential oil, the improvement wherein the essential oil is the combination according to claim 8 .

12 . In a method for prevention or treatment of infectious diseases of bacterial origin using an essential oil, the improvement wherein the essential oil is the combination according to claim 8 .

13 . The method according to claim 12 , wherein said essential oil is previously extracted from French lavender and the bacterium is S. aureus.

14 . The combination according to claim 9 , wherein the second essential oil is transformed by a method comprising:
providing a previously extracted essential oil; evaporating a fraction of between 7 and 90% of the essential oil for at least 2 hours, under a pressure less than or equal to 500 mbar and at a temperature between 4° and 100° C.; and obtaining a transformed essential oil comprising the recovery of the unevaporated essential oil fraction.

Assignees

• Pranarom Int S A
• Univ Bruxelles
• Univ Grenoble Alpes
• Centre Nat Rech Scient

Inventors

• Zhiri Abdesselam
• Oliveira Ribeiro Sofia
• Stevigny Caroline
• Souard Florence
• Baudoux Dominique

Classifications

• A61K45/06 Primary

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K36/28

  Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea · CPC title

• A61K2236/35

  Extraction with lipophilic solvents, e.g. Hexane or petrol ether · CPC title

• A61K2236/33

  involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones · CPC title

• A61P31/10

  Antimycotics · CPC title