CD3 binding molecules

Patent metadata

Field	Value
Publication number	US-12460002-B2
Application number	US-202017438768-A
Country	US
Kind code	B2
Filing date	Mar 27, 2020
Priority date	Mar 29, 2019
Publication date	Nov 4, 2025
Grant date	Nov 4, 2025

Abstract

The invention relates to heavy chain variable regions, binding domains and antibodies specific for human CD3, and CD3 binding proteins. The invention further relates to the use of a CD3 binding protein, preferably an antibody, of the invention in the treatment of cancer or autoimmune disease.

First claim

The invention claimed is:

1 . An antigen-binding protein that binds human CD3 comprising an antibody variable domain comprising a heavy chain variable region and a light chain variable region wherein the heavy chain variable region comprises:
a CDR1, CDR2 and CDR3 comprising the amino acid sequence:

CDR1: 

(SEQ ID NO: 42)

SFGIS

CDR2: 

(SEQ ID NO: 43)

GFIPVLGTANYAQKFQG 

CDR3: 

(SEQ ID NO: 44)

RGNWNPFDP;

or
comprising the amino acid sequence:

CDR1: 

(SEQ ID NO: 51)

SKTFTIS;

CDR2: 

(SEQ ID NO: 52)

GIIPLFGTITYAQKFQG;

CDR3: 

(SEQ ID NO: 53)

RGNWNPFDP;

or
comprising the amino acid sequence:

CDR1: 

(SEQ ID NO: 60)

SRTFTIS;

CDR2: 

(SEQ ID NO: 61)

SIIPIFGTITYAQKFQG;

CDR3:

(SEQ ID NO: 62)

RGNWNPFDP;

or
comprising the amino acid sequence:

CDR1: 

(SEQ ID NO: 84)

SKTLTIS;

CDR2: 

(SEQ ID NO: 85)

GIIPIFGSITYAQKFQD;

CDR3: 

(SEQ ID NO: 86)

RGNWNPFDP,

or
comprising the amino acid sequence:

CDR1: 

(SEQ ID NO: 68)

GSGIS;

CDR2: 

(SEQ ID NO: 69)

GFIPFFGSANYAQKFRD;

CDR3: 

(SEQ ID NO: 70)

RGNWNPLDP;

or
comprising the amino acid sequence:

CDR1:

(SEQ ID NO: 100)

GSGIS;

CDR2:

(SEQ ID NO: 101)

GFIPFFGSANYAQKFRD;

CDR3: 

(SEQ ID NO: 102)

RGNWNPFDP;

or
comprising the amino acid sequence:

CDR1: 

(SEQ ID NO: 199)

RFWIG;

CDR2: 

(SEQ ID NO: 200)

IIYPGDSDTRYSPSFQG;

CDR3:

Assignees

• Merus Nv

Inventors

• Van Loo Pieter Fokko

Classifications

• C07K2317/92

  Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value · CPC title

• C07K2317/565

  Complementarity determining region [CDR] · CPC title

• C07K2317/55

  Fab or Fab' · CPC title

• C07K2317/53

  Hinge · CPC title

• C07K2317/526

  CH3 domain · CPC title