Medical device packaging and related methods

Patent metadata

Field	Value
Publication number	US-12458746-B2
Application number	US-202318466173-A
Country	US
Kind code	B2
Filing date	Sep 13, 2023
Priority date	Jul 29, 2019
Publication date	Nov 4, 2025
Grant date	Nov 4, 2025

Abstract

According to one aspect of the disclosure, packaging for a sterile syringe having a nominal size of less than 1 mL may include a flexible tray having a cavity for containing the syringe. The cavity may include an opening, one or more sidewalls, and a base. A lip may surround the opening, may extend radially outward from the cavity, and may define a periphery of the tray. A removable cover may have a periphery that is adhered to the lip, and the removable cover may be permeable to a gaseous sterilant, including one or more of vaporized hydrogen peroxide or ethylene oxide. A projection may be associated with the base of the cavity and may extend away from the base of the cavity in a direction opposite to the opening of the cavity.

First claim

What is claimed is:

1 . A method of removing a syringe from a packaging, the method comprising:
peeling off a removable cover from a blister packaging tray of the packaging, the blister packaging tray having a cavity configured to contain the syringe therein, wherein the blister packaging tray includes a dome-shaped projection associated with and extending away from a base of the cavity of the blister packaging tray in a direction opposite to an opening of the cavity, and the dome-shaped projection is aligned with the syringe; pushing a portion of the dome-shaped projection towards the cavity of the blister packaging tray, wherein pushing the portion of the dome-shaped projection causes a portion of the blister packaging tray to flex; and orienting the blister packaging tray so that the opening of the cavity faces a sterile surface to release the syringe from the blister packaging tray.

2 . The method of claim 1 , wherein the syringe is pre-filled with aflibercept, ranibizumab, bevacizumab, conbercept, OPT-302, RTH258 (brolucizumab), a pegylated designed ankyrin repeating protein (DARPin), or RG7716.

3 . The method of claim 1 , wherein the blister packaging tray is fabricated from a material including one or more of polypropylene, polystyrene, polyethylene, polycarbonate, polyvinyl chloride, or polyethylene terephthalate glycol.

4 . The method of claim 1 , wherein the removable cover is permeable to a gaseous sterilant.

5 . The method of claim 4 , wherein the gaseous sterilant is vaporized hydrogen peroxide.

6 . The method of claim 1 , wherein the syringe includes a barrel with an outer diameter and the dome-shaped projection includes a diameter greater than the outer diameter of the barrel.

7 . A method of removing a syringe from a packaging, the packaging including a tray having a cavity, a dome-shaped projection associated with the cavity, and an opening covered by a gas-permeable material, wherein the dome-shaped projection extends away from a base of the cavity in a direction opposite to the opening of the tray;
the method comprising:
removing the gas-permeable material so as to expose the opening of the tray;
pushing the dome-shaped projection towards the cavity and a barrel of the syringe, wherein the step of pushing the dome-shaped projection also causes a portion of the tray to flex; and
ejecting the syringe from the tray.

8 . The method of claim 7 , wherein ejecting the syringe from the tray is performed without a user directly handling the syringe.

9 . The method of claim 7 , wherein the gas-permeable material is permeable to vaporized hydrogen peroxide or ethylene oxide.

10 . The method of claim 7 , wherein the dome-shaped projection includes a bulbous shape and a diameter that is greater than an outer diameter of the barrel of the syringe.

11 . The method of claim 10 , wherein the diameter of the dome-shaped projection defines a widest portion of the bulbous shape where the dome-shaped projection meets the base of the cavity.

12 . The method of claim 7 , wherein the syringe is pre-filled with aflibercept, ranibizumab, bevacizumab, ranibizumab, bevacizumab, conbercept, OPT-302, RTH258 (brolucizumab), a pegylated designed ankyrin repeating protein (DARPin), or RG7716.

13 . The method of claim 7 , wherein, prior to the removing step, the packaging containing the syringe is sterilized with a gaseous sterilant.

14 . The method of claim 7 , wherein the gas-permeable material is formed of one or more of high-density polyethylene fibers, ethylene-vinyl acetate, or thermoplastic materials.

15 . The method of claim 7 , wherein the dome-shaped projection includes a dome having a widest diameter at the base of the cavity, wherein the dome-shaped projection extends directly outward from the base such that the widest diameter of the dome is connected at the base.

16 . The method of claim 15 , wherein when the syringe is disposed within the cavity, a height of the dome-shaped projection from an apex of the dome to a base of the dome-shaped projection is greater than a distance between the base of the dome-shaped projection and a portion of the syringe contained within the cavity and overlying the dome-shaped projection.

17 . The method of claim 7 , wherein the dome-shaped projection is hollow and open towards the cavity.

18 . A method of removing a syringe from a packaging that includes a flexible tray having a base for receiving the syringe and a dome-shaped projection extending away from the base in a direction opposite to the syringe;
the method comprising:
removing a cover that is coupled to the flexible tray and disposed over the base to expose an opening of the flexible tray, wherein the cover is permeable to a gaseous sterilant;
pushing the dome-shaped projection towards the syringe to flex a portion of the base, wherein the dome-shaped projection is hollow and open towards the opening of the flexible tray; and
ejecting the syringe from the base.

19 . The method of claim 18 , wherein the dome-shaped projection is configurable to move relative to the base in response to receiving a force at a portion of the dome-shaped projection when pushing the dome-shaped projection.

20 . The method of claim 18 , wherein the base defines a cavity that includes a first cavity portion configured to contain a plunger of the syringe, a second cavity portion configured to contain a barrel of the syringe, and a third cavity portion configured to contain a needle attachment portion of the syringe; and
wherein the dome-shaped projection extends away from the second cavity portion.

Assignees

• Regeneron Pharma

Inventors

• Cook Andrew
• Bradford Victor

Classifications

• B65D75/36

  one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages {, the recess or recesses being preformed (B65D73/0057, B65D73/0092 take precedence)} · CPC title

• B65D85/70

  for materials not otherwise provided for · CPC title

• B65D83/00

  Containers or packages with special means for dispensing contents (dispensing means incorporated in closures B65D47/00) · CPC title

• B65D75/5855

  Peelable seals · CPC title

• B65B69/005

  by expelling contents, e.g. by squeezing the container · CPC title