Chimeric polynucleotides
US-2016194625-A1 · Jul 7, 2016 · US
Polymer nanoparticle compositions for in vivo expression of polypeptides
US12458606B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12458606-B2 |
| Application number | US-202418902113-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 30, 2024 |
| Priority date | Sep 29, 2023 |
| Publication date | Nov 4, 2025 |
| Grant date | Nov 4, 2025 |
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- Title
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Abstract
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The disclosure relates to block copolymer nanoparticles for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering nucleotides that encode polypeptides.
First claim
Opening claim text (preview).
The invention claimed is: 1 . A block copolymer comprising a first block and a second block, wherein (i) the first block comprises poly-2-(dimethylamino)ethyl methacrylate (DMAEMA); and (ii) the second block comprises a copolymer of butylmethacrylate (BMA) and vinylmethacrylate (VMA). 2 . A polymer nanoparticle comprising: a block copolymer according claim 1 , wherein the nanoparticle has a hydrodynamic diameter of about 10 nm to about 1000 nm. 3 . The polymer nanoparticle of claim 2 , wherein the nanoparticle has a hydrodynamic diameter of about 10 nm to about 500 nm. 4 . A composition comprising: a polymer nanoparticle according to claim 2 , and a nucleic acid complexed to the polymer nanoparticle. 5 . The composition of claim 4 , wherein the nucleic acid encodes an antibody. 6 . A method of treating a disease in a patient in need thereof, the method comprising: administering a therapeutically effective amount of a composition according to claim 4 . 7 . The block copolymer of claim 1 , wherein the second block comprises about 20 to about 80 mol % BMA. 8 . The block copolymer of claim 1 , wherein the first block homopolymer has a molecular weight of at least about 20,000 Da.
Assignees
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Classifications
the unsaturation being in acrylic or methacrylic groups · CPC title
Sugars, nucleosides, nucleotides or nucleic acids · CPC title
the polymer being obtained by reactions only involving carbon to carbon, e.g. poly(meth)acrylate, polystyrene, polyvinylpyrrolidone or polyvinylalcohol · CPC title
- A61K9/5138Primary
obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates · CPC title
using microencapsulation, e.g. using {amphiphile} liposome vesicle · CPC title
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- What does patent US12458606B2 cover?
- The disclosure relates to block copolymer nanoparticles for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering nucleotides that encode polypeptides.
- Who is the assignee on this patent?
- Battelle Memorial Institute
- What technology area does this patent fall under?
- Primary CPC classification A61K9/5138. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).