Apparatus for destroying biological tissue and method for trapping biological tissue in fluids flow using the same

Patent metadata

Field	Value
Publication number	US-12458381-B2
Application number	US-202418652979-A
Country	US
Kind code	B2
Filing date	May 2, 2024
Priority date	May 10, 2023
Publication date	Nov 4, 2025
Grant date	Nov 4, 2025

Abstract

Provided is a method for operating an apparatus for destroying biological tissue operated by at least one processor, which generates a trapping control signal for controlling movement of the biological tissue moving by a fluid. An acoustic field for controlling the movement of the biological tissue is generated by outputting a first focused ultrasound based on the trapping control signal. A second focused ultrasound is output to the biological tissue based on a destruction control signal for destroying the biological tissue whose movement is controlled by the acoustic field.

First claim

What is claimed is:

1 . A method for operating an apparatus for destroying biological tissue operated by at least one processor, comprising:
generating a trapping control signal for controlling movement of the biological tissue moving by a fluid; generating an acoustic field for controlling the movement of the biological tissue by outputting first focused ultrasounds including a first focused ultrasound for trapping and a second focused ultrasound for trapping based on the trapping control signal, a phase of the first focused ultrasound for trapping and a phase of the second focused ultrasound for trapping being reversed by 180°, and the first focused ultrasound for trapping and the second focused ultrasound for trapping being arranged to face one focal area; and outputting a second focused ultrasound based on a destruction control signal generated to destroy the biological tissue whose movement is controlled by the acoustic field.

2 . The method of claim 1 , wherein
the generating of the trapping control signal includes: receiving a medical image including the biological tissue; and generating the destruction control signal for destroying the biological tissue according to characteristics and a size of the biological tissue.

3 . The method of claim 1 , wherein
in the generating of the trapping control signal, by generating the trapping control signal including a first pulse length, a first pulse repetition frequency, a first ultrasound output frequency, a second pulse length, a second pulse repetition frequency, and a second ultrasound output frequency, the movement of the biological tissue larger than a preset critical size or larger than the size of the biological tissue is controlled.

4 . The method of claim 3 , wherein
the first focused ultrasound for trapping has the first pulse length and the first pulse repetition frequency and the second focused ultrasound for trapping has the second pulse length and the second pulse repetition frequency, and the acoustic field formed in the fluid using the first focused ultrasound for trapping and the second focused ultrasound for trapping is formed into a plurality of lines by sequentially arranging antinodes and nodes.

5 . The method of claim 4 , wherein
an antinode-node spacing and radiation power generated by the antinodes are adjusted by adjusting an ultrasound output of the first pulse repetition frequency and the second pulse repetition frequency, and the first focused ultrasound for trapping and the second focused ultrasound for trapping have an ultrasound center frequency of 0.1 MHz to 10 MHZ, a pulse repetition frequency of 0.1 Hz to 100 Hz, a pulse length ranging from 0.1 ms to 1000 ms, a pulse repetition frequency ranging from 0.1 Hz to 500 Hz, and pressure intensity ranging from 0.01 MPa to 5 MPa.

6 . The method of claim 1 , wherein
in the outputting of the second focused ultrasound, the biological tissue whose movement is controlled by the acoustic field is destroyed using acoustic cavitation generated in a blood vessel including the fluid through the second focused ultrasound.

7 . The method of claim 6 , wherein
the second focused ultrasound has an ultrasound center frequency of 0.1 MHz to 10 MHZ, a pulse length ranging from 0.1 ms to 100 ms, a pulse repetition frequency ranging from 0.1 Hz to 500 Hz, and a pressure of a maximum static pressure of 40 MPa or more and a maximum negative pressure of 10 MPa or less.

8 . The method of claim 1 , further comprising:
after the outputting of the second focused ultrasound, confirming whether the movement of the biological tissue is controlled based on an acoustic signal generated by the output of the first focused ultrasound; and confirming whether the biological tissue is destroyed based on an acoustic signal generated by the output of the second focused ultrasound.

9 . The method of claim 1 , further comprising:
after the outputting of the second focused ultrasound, generating another trapping control signal for controlling the movement of any one of remaining biological tissues that pass through the acoustic field or the remaining biological tissues from which the biological tissue is destroyed; generating another acoustic field by outputting a third focused ultrasound based on the another trapping control signal; and outputting a fourth focused ultrasound based on another destruction control signal for destroying the remaining biological tissues whose movement is controlled by the another acoustic field.

10 . The method of claim 1 , wherein
the generating of the trapping control signal further includes generating the trapping control signal when a driving start signal of the apparatus for destroying biological tissue is generated or an ultrasound image including the biological tissue is input from a probe linked to the apparatus for destroying biological tissue.

11 . An apparatus for destroying biological tissue operated by at least one processor, comprising:
a memory configured to store one or more instructions; and a processor that when executing the one or more instructions is configured to:
generate a trapping control signal for controlling movement of the biological tissue moving by a fluid and generating an acoustic field for controlling the movement of the biological tissue by outputting first focused ultrasounds including a first focused ultrasound for trapping and a second focused ultrasound for trapping based on the trapping control signal, a phase of the first focused ultrasound for trapping and a phase of the second focused ultrasound for trapping being reversed by 180°, and the first focused ultrasound for trapping and the second focused ultrasound for trapping being arranged to face one focal area; and
generate a destruction control signal for destroying the biological tissue whose movement is controlled based on the acoustic field and outputting a second focused ultrasound based on the destruction control signal for destroying the biological tissue whose movement is controlled by the acoustic field.

12 . The apparatus of claim 11 , wherein
the processor is further configured to: generate a trapping control signal including a first pulse length, a first pulse repetition frequency, a first ultrasound output frequency, a second pulse length, a second pulse repetition frequency, and a second ultrasound output frequency; output the first focused ultrasound for trapping based on the first pulse length and the first pulse repetition frequency; and output the second focused ultrasound for trapping based on the second pulse length and the second pulse repetition frequency.

13 . The apparatus of claim 12 , wherein
the acoustic field formed in the fluid using the first focused ultrasound for trapping and the second focused ultrasound for control is formed into a plurality of lines by sequentially arranging antinodes and nodes.

14 . The apparatus of claim 13 , wherein
the processor is further configured to maintain an angular range of each ultrasound irradiation axis between 10° and 180°.

15 . The apparatus of claim 14 , wherein
the first focused ultrasound for trapping and the second focused ultrasound for trapping has an ultrasound center frequency of 0.1 MHz to 10 MHZ, a pulse length ranging from 0.1 ms to 1000 ms, a pulse repetition frequency ranging from 0.1 Hz to 500 Hz, and pressure intensity ranging from 0.01 MPa to 5 MPa.

16 . The apparatus of claim 11 , wherein
the processor is further configured to: generate the destruction control signal for destroying the biological tissue according to char

Assignees

• Univ Industry Cooperation Group Kyung Hee Univ

Inventors

• Pahk Ki Joo
• Heo Jeong Min
• Park Jun Hong
• Kim Hyojun
• Pahk Kisoo
• Han Sungmin

Classifications

• A61B2017/00154

  pulsed · CPC title

• A61B2017/00137

  Details of operation mode · CPC title

• A61B2017/22025

  applying a shock wave (A61B2017/22091 takes precedence) · CPC title

• A61B2017/22007

  Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing · CPC title

• A61B17/22012

  in direct contact with, or very close to, the obstruction or concrement (for removing obstructions in blood vessels by laser A61B18/245) · CPC title