Mesh for dissolution test

Patent metadata

Field	Value
Publication number	US-12455270-B2
Application number	US-202017601539-A
Country	US
Kind code	B2
Filing date	Apr 7, 2020
Priority date	Apr 8, 2019
Publication date	Oct 28, 2025
Grant date	Oct 28, 2025

Abstract

When the mesh is placed under the bottom of a blade and over the bottom of a vessel in the dissolution test assembly equipped with either a vessel specified in the dissolution test method of the Japanese Pharmacopoeia, the United States Pharmacopoeia or the European Pharmacopoeia or a vessel used for the dissolution test, and a paddle formed from a blade and a shaft, and the suspensions and the solid dosage forms are added to or placed at the said mesh, a drug dissolves from the said dosage forms and the dissolution ratio variation between the said multiple same dosage forms can be small.

First claim

The invention claimed is:

1 . A method of preventing coning of a suspension or a solid dosage form selected from the group consisting of a suspension, a syrup, a tablet, a capsule, a granule and a pill in a dissolution test of the suspension or the solid dosage form, the method comprising:
using one single-layer mesh for the test, placing the one single-layer mesh under a bottom of a blade and above a bottom of a vessel in a dissolution test assembly comprising the vessel used in the dissolution test, and a paddle comprising the blade and a shaft, wherein the paddle has a rotating speed of 10 to 30 rpm, and placing the suspension or the solid dosage form on the one single-layer mesh.

2 . The method according to claim 1 , wherein the one single-layer mesh is placed at 5 to 35 mm under the bottom of the blade.

3 . The method according to claim 1 , wherein the one single-layer mesh is placed at 1 to 30 mm above the bottom of the vessel.

4 . The method according to claim 1 , wherein the one single-layer mesh is placed at 5 to 35 mm under the bottom of the blade and at 1 to 30 mm above the bottom of the vessel.

5 . The method according to claim 1 , further comprising forming the one single-layer mesh into a circle having a diameter between 10 and 95 mm.

6 . The method according to claim 1 , wherein the one single-layer mesh has a sieve opening of 2 to 200 mesh.

7 . The method according to claim 1 , wherein the one single-layer mesh comprises an edge part.

8 . The method according to claim 1 , wherein the one single-layer mesh comprises a leg part.

Assignees

• Shionogi & Co

Inventors

• Horiuchi Kensuke
• MATSUURA Satoyo
• Okabe Maki

Classifications

• G01N13/00

  Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects (scanning-probe techniques or apparatus G01Q) · CPC title

• B01F21/10

  using driven stirrers · CPC title

• G01N2013/006

  Dissolution of tablets or the like · CPC title

• B01L2300/0609

  Holders integrated in container to position an object · CPC title

• G01N33/15 Primary

  Medicinal preparations {; Physical properties thereof, e.g. dissolubility} · CPC title