Particle-producing method and particle-producing apparatus
US-2019247314-A1 · Aug 15, 2019 · US
US12453704B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12453704-B2 |
| Application number | US-202117906326-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 11, 2021 |
| Priority date | Mar 16, 2020 |
| Publication date | Oct 28, 2025 |
| Grant date | Oct 28, 2025 |
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Provided is a method for producing particles including: preparing a dispersion liquid with Liquid A and Liquid B, where Liquid A is a solution containing a physiologically active substance, and Liquid B is a solution containing a base material and a surfactant; and forming particles from the dispersion liquid.
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The invention claimed is: 1. A method for producing particles, the method comprising: preparing a dispersion liquid with Liquid A and Liquid B, where Liquid A is a solution comprising a physiologically active substance, and Liquid B is a solution comprising a base material and a surfactant; and forming particles from the dispersion liquid, wherein the surfactant comprises sorbitan sesquioleate, the base material comprises a biodegradable resin which comprises at least one resin selected from the group consisting of polylactic acid and a polylactic acid-glycolic acid copolymer, the physiologically active substance is an antibody, and the particles are sustained-release particles. 2. The method according to claim 1 , wherein the dispersion liquid is a W/O emulsion. 3. The method according to claim 1 , wherein a hydrophilic-lipophilic balance of the surfactant is 1 or greater but 8 or less. 4. The method according to claim 3 , wherein the hydrophilic-lipophilic balance of the surfactant is 3 or greater but 6 or less.
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