Hericium erinaceus strain HE015, molecular markers and uses thereof

Patent metadata

Field	Value
Publication number	US-12448657-B2
Application number	US-202418726821-A
Country	US
Kind code	B2
Filing date	Apr 26, 2024
Priority date	Mar 28, 2024
Publication date	Oct 21, 2025
Grant date	Oct 21, 2025

Abstract

The present invention discloses a new Hericium erinaceus strain HE015, and a molecular marker and use thereof. Wild fungi are widely collected throughout China and subjected to systematic strain breeding to obtain a new fine-quality Hericium erinaceus strain HE015. The strain HE015 was preserved in Guangdong Microbial Culture Collection Center on May 12, 2022 with an accession number of GDMCC No: 62464. The genetic background of the strain is obviously different from that of the existing Hericium erinaceus species; therefore, the new strain is of important value and significance in supplementing fine-quality cultivated Hericium erinaceus varieties, meeting the market demand and promoting high-quality development of the industry. The present invention further provides a specific molecular marker and a rapid detection method for detecting and identifying the strain HE015.

First claim

What is claimed is:

1. A method of protecting gastric mucosa or improving alcohol-induced gastric mucosal damage, comprising: administering an effective amount of Hericium erinaceus strain HE015 extract, wherein the Hericium erinaceus strain HE015's representative sample is deposited at Guangdong Microbial Culture Collection Center under accession number of GDMCC No: 62464, and the Hericium erinaceus HE015 extract comprises Hericium erinaceus HE015 fruiting body polysaccharide extract, small-molecule Hericium erinaceus HE015 fruiting body extract, solid-cultured Hericium erinaceus HE015 mycelia polysaccharide extract, or solid-cultured small-molecule Hericium erinaceus HE015 mycelia extract.

2. A Hericium erinaceus inoculant, comprising Hericium erinaceus strain HE015 and a PDA medium, wherein the Hericium erinaceus strain HE015's representative sample is deposited at Guangdong Microbial Culture Collection Center under accession number of GDMCC No: 62464.

Assignees

• Infinitus China Co Ltd
• Inst Of Microbiology Guangdong Academy Of Sciences Guangdong Detection Center Of Microbiology

Inventors

• Zhou Yong
• Wu Qingping
• Cai Manjun
• Kou Xiuying
• Liu Yuanchao
• Wu Xiaoxian
• Hu Huiping
• Zhuo Lijun
• Tang Jian
• Tao Qian
• Xie Yizhen
• Zhang Zhi

Classifications

• C12Q1/6869

  Methods for sequencing · CPC title

• A01H15/00

  Fungi; Lichens (fungal microorganisms C12N1/14) · CPC title

• C12R2001/645

  Fungi {; Processes using fungi} · CPC title

• C12Q2600/156

  Polymorphic or mutational markers · CPC title

• C12Q1/6895 Primary

  for plants, fungi or algae · CPC title