Compounds with immunomodulatory activity and therapeutic uses thereof

Patent metadata

Field	Value
Publication number	US-12448359-B2
Application number	US-202117908530-A
Country	US
Kind code	B2
Filing date	Mar 5, 2021
Priority date	Mar 11, 2020
Publication date	Oct 21, 2025
Grant date	Oct 21, 2025

Abstract

The present invention generally relates to new compounds for therapeutic uses. In particular, the disclosed series compounds with immunomodulatory activities are useful for treatment of dysfunctions of the immune system and various cancers. Pharmaceutical composition matters and methods for treating a patient with an immune disease and/or a cancer by administering therapeutically effective amounts of such compound alone or together with other therapeutics are within the scope of this disclosure.

First claim

The invention claimed is:

1. A compound having the formula (I):

or a pharmaceutically acceptable salt thereof, wherein
Ar 1 is 2,3-dihydrobenzo [b] [1,4]-dioxinyl;
R 1 and R 2 are each, independently, alkyloxy;
R 3 is alkyl; and

Q is

2. The compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are each methoxyl.

3. The compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is CH 3 .

4. The compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is:

5. A pharmaceutical composition comprising one or more compounds of claim 1 , or a pharmaceutically acceptable salt thereof, together with one or more diluents, excipients or carriers.

6. A method for treating a cancer patient, which method comprises administering a therapeutically effective amount of one or more compounds of claim 1 , or a pharmaceutical composition comprising same and one or more carriers, diluents, or excipients, to the cancer patient.

7. The method according to claim 6 , wherein said cancer is castration-resistant prostate cancer.

Assignees

• Purdue Research Foundation

Inventors

• Chopra Gaurav
• Wijewardhane Prageeth
• Jethava Krupal P
• Fine Jonathan

Classifications

• C07F5/027

  Organoboranes and organoborohydrides · CPC title

• C07D419/14

  containing three or more hetero rings · CPC title

• C07D419/04

  directly linked by a ring-member-to-ring-member bond · CPC title

• C07D413/14

  containing three or more hetero rings · CPC title

• C07D413/06

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title