Hypertension therapy

Patent metadata

Field	Value
Publication number	US-12447347-B2
Application number	US-202117920536-A
Country	US
Kind code	B2
Filing date	Apr 16, 2021
Priority date	Apr 27, 2020
Publication date	Oct 21, 2025
Grant date	Oct 21, 2025

Abstract

An implantable device for stimulating a heart to lower blood pressure, comprising: a stimulation unit configured to stimulate a ventricle, and a sensing unit for detecting atrial activity of the heart, wherein the stimulation unit is configured to stimulate the ventricle for at least one cardiac cycle with a predefined delay after detection of an atrial activity or to not stimulate the ventricle for at least one cardiac cycle.

First claim

The invention claimed is:

1. An implantable device for stimulating a heart to lower blood pressure, comprising:
a stimulation unit configured to stimulate a ventricle and/or an atrium, and
a sensing unit for detecting atrial activity of the heart,
wherein
the stimulation unit is configured to stimulate the ventricle for at least one cardiac cycle with a predefined delay after detection of an atrial activity and to subsequently not stimulate the ventricle with a predefined delay after the detection of an atrial activity for at least one cardiac cycle, wherein the implantable device is configured to suspend stimulation of the ventricle triggered by said detection of an atrial activity after a predefined number of heart cycles or after a predetermined time period for a number of heart cycles or for a predetermined time period,
wherein the stimulation unit is configured to stimulate the ventricle irrespective of atrial activity for at least one cardiac cycle after the detection of an atrial activity or after the stimulation of the atrium in the absence of intrinsic AV conduction.

2. An implantable device for stimulating a heart to lower blood pressure, comprising:
a stimulation unit configured to stimulate a ventricle, and
a sensing unit for detecting atrial activity of the heart, and
a stimulation unit configured to stimulate an atrium,
wherein
the stimulation unit is configured to stimulate the ventricle for at least one cardiac cycle with a predefined delay after detection of an atrial activity or with a predefined delay after the stimulation of an atrium and to subsequently not stimulate the ventricle with a predefined delay after the detection of an atrial activity for at least one cardiac cycle, wherein the implantable device is configured to suspend stimulation of the ventricle triggered by said detection of an atrial activity or triggered by an atrial stimulation after a predefined number of heart cycles or after a predetermined time period for a number of heart cycles or for a predetermined time period,
wherein the stimulation unit is configured to stimulate the ventricle irrespective of atrial activity for at least one cardiac cycle after the detection of an atrial activity or after the stimulation of the atrium in the absence of intrinsic AV conduction.

3. The implantable device according to claim 1 , wherein said delay is less than 100 ms.

4. The implantable device according to claim 1 , wherein said delay is adjustable, and wherein the implantable device is configured to adjust the delay to be shorter than an intrinsic AV delay of the patient.

5. The implantable device according to claim 1 , wherein the implantable device comprises a ventricular sensing unit, and wherein the implantable device is configured to measure an intrinsic AV delay of the patient and to adjust said adjustable delay depending on the measured intrinsic AV delay, wherein the adjustable delay is adjusted to be shorter than said measured intrinsic AV delay.

6. The implantable device according to claim 1 , wherein the implantable device is configured to suspend the stimulation of the ventricle triggered by the detection of an atrial activity or triggered by the atrial stimulation depending on one or more parameters that can be assigned to the systemic blood pressure.

7. The implantable device according to claim 6 , wherein the implantable device is configured to measure the respective parameter or to receive the respective parameter from another device.

8. The implantable device according to claim 1 , wherein the ventricle is the right ventricle, or wherein the ventricle is the left ventricle, or wherein the stimulation unit is configured to stimulate the left and the right ventricle for at least one cardiac cycle with said predefined delay after the detection of an atrial activity or after the stimulation of the atrium, and configured to subsequently not stimulate the left and the right ventricle with a predefined delay after the detection of an atrial activity or with a predefined delay after the stimulation of the atrium for at least one cardiac cycle.

9. A method for lowering blood pressure by means of cardiac stimulation, particularly using an implantable device according to claim 1 , wherein the ventricle is stimulated for at least one cardiac cycle with a predefined delay after detection of an atrial activity or with a predefined delay after the stimulation of an atrium and is subsequently not stimulated synchronously after atrial activity or an atrial stimulation for at least one cardiac cycle, wherein the ventricle is stimulated irrespective of atrial activity for at least one cardiac cycle after the detection of an atrial activity or after the stimulation of the atrium in the absence of intrinsic AV conduction.

10. The method according to claim 9 , wherein the ventricle is stimulated for at least one cardiac cycle with a predefined delay after detection of an atrial activity or with a predefined delay after the stimulation of the atrium and is subsequently not stimulated synchronously after atrial activity or the atrial stimulation for at least one cardiac cycle.

11. The method according to claim 9 , wherein the cardiac stimulation is delivered to patients indicated with Heart Failure with preserved Ejection Fraction.

Assignees

• Biotronik Se & Co Kg

Inventors

• Doerr Thomas
• Weiss Ingo
• Busch Ulrich

Classifications

• A61N1/3684

  for stimulating the heart at multiple sites of the ventricle or the atrium · CPC title

• A61N1/3682

  with a variable atrioventricular delay · CPC title

• A61N1/36843

  Bi-ventricular stimulation · CPC title

• A61N1/36117

  for treating hypertension · CPC title

• A61N1/3627 Primary

  for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy · CPC title