Unilaterally driven closed-loop artificial pancreas and data obtaining method for program module thereof

Patent metadata

Field	Value
Publication number	US-12447267-B2
Application number	US-202017787593-A
Country	US
Kind code	B2
Filing date	Aug 26, 2020
Priority date	Aug 1, 2019
Publication date	Oct 21, 2025
Grant date	Oct 21, 2025

Abstract

A unilaterally driven closed-loop artificial pancreas, includes: a detection module, an infusion module and a program module. The infusion module includes a reservoir, a piston, a screw, a driving unit, a driving wheel provided with wheel teeth, at least one linear actuator and at least one reset unit. The driving unit includes at least one rotating shaft and at least one driving member. The driving member includes a driving end. The driving member rotates around the rotating shaft. The linear actuator and the reset unit respectively connect to the driving member. The program module is connected to the detection module and the infusion module respectively, imported the total daily dose algorithm and the current insulin infusion algorithm. The driving power can be controlled, and it can accurately calculate the TDD value and the current insulin infusion dose.

First claim

The invention claimed is:

1. A unilaterally driven closed-loop artificial pancreas, comprising:
a detection module configured to continuously detect a real-time blood glucose level;
an infusion module, comprising:
a reservoir, a piston and a screw, wherein the piston, connected with the screw, is arranged in the reservoir;
a driving unit, wherein the driving unit comprises at least one rotating shaft, at least one driving member, the driving member includes a driving end, and the driving member rotates around the rotating shaft to advance the driving end;
at least one driving wheel provided with wheel teeth, wherein the driving end which is advancing pushes the wheel teeth to rotate the driving wheel, thereby driving the screw forward;
at least one linear actuator and at least one reset unit which are connected to the driving member, wherein the linear actuator provides the driving member with power to advance the driving end, the reset unit applies a force to the driving member to make the driving end rotate in a reset direction; and

a program module, which is connected to the detention module and the infusion module, is imported a total daily dose algorithm and a current insulin infusion algorithm, and a force output of the linear actuator or the reset unit is controlled by the program module according to a calculation result of the current insulin infusion algorithm, thereby controlling the infusion module to infuse insulin required,
wherein the linear actuator comprises an electrically driven linear actuator or an electrically heated linear actuator.

2. The unilaterally driven closed-loop artificial pancreas of claim 1 , wherein
the reset unit includes an electrically driven linear actuator, an electrically heated linear actuator, or an elastic member.

3. The unilaterally driven closed-loop artificial pancreas of claim 2 , wherein
the elastic member includes a spring or conductive rubber.

4. The data obtaining method for program module of unilaterally driven closed-loop artificial pancreas, comprising:
providing a unilaterally driven closed-loop artificial pancreas of claim 1 , wherein the program module includes a manual input interface or an automatic detection sub-module, and the method for the program module to obtain the insulin dose infused per day by users comprises: the insulin dose infused per day by users is manually input into the program module through the manual input interface; or the insulin dose infused per day by users is automatically detected, stored and calculated by the automatic detection sub-module.

5. The data obtaining method for program module of unilaterally driven closed-loop artificial pancreas of claim 4 , wherein
the insulin dose infused per day by users includes a total amount of daily infusion dose data, or a bolus and basal data infused in different time periods, or a temporary basal data and a correction bolus data, or an infusion data after different events.

6. The data obtaining method for program module of unilaterally driven closed-loop artificial pancreas of claim 5 , wherein
the total daily dose is obtained by calculating the total amount of daily infusion dose data in previous two or more days according to the total daily dose algorithm, and the total daily dose is an average or a median of the insulin dose infused per day by users, and the total daily dose is one variable factor of the current insulin infusion algorithm.

7. The data obtaining method for program module of unilaterally driven closed-loop artificial pancreas of claim 4 , wherein
variable factors of the total daily dose algorithm comprise one or more of user's physical activity status, physiological status, psychological status, and meal status.

8. The data obtaining method for program module of unilaterally driven closed-loop artificial pancreas of claim 7 , wherein the physical activity status comprises general body stretching, exercise, or sleep.

9. The unilaterally driven closed-loop artificial pancreas of claim 1 , further comprising a motion sensor, wherein the motion sensor which is provided in the detection module, the program module or the infusion module, is used to automatically sense user's physical activity status which is sent to the program module and is one of variable factors of the total daily dose algorithm or the current insulin infusion algorithm.

10. The unilaterally driven closed-loop artificial pancreas of claim 9 , wherein
the motion sensor comprises a three-axis acceleration sensor or a gyroscope.

11. The unilaterally driven closed-loop artificial pancreas of claim 1 , wherein
any two of the detection modules, the program module and the infusion module are connected to each other configured to form a single structure whose attached position on a skin is different from a rest one of the detection module, the program module and the infusion module.

12. The unilaterally driven closed-loop artificial pancreas of claim 1 , wherein
the detection module, the program module and the infusion module are connected together configured to form a single structure which is attached on only one position on the skin.

Assignees

• Medtrum Tech Inc

Inventors

• Yang Cuijun

Classifications

• A61M5/1723

  using feedback of body parameters, e.g. blood-sugar, pressure (measurement of body parameters A61B5/00) · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• G16H40/67

  for remote operation · CPC title

• A61M2205/3327

  Measuring · CPC title

• A61M2205/3317

  Electromagnetic, inductive or dielectric measuring means · CPC title