Dialysis system with continuous glucose monitoring

Patent metadata

Field	Value
Publication number	US-12447247-B2
Application number	US-202017771076-A
Country	US
Kind code	B2
Filing date	Oct 23, 2020
Priority date	Oct 25, 2019
Publication date	Oct 21, 2025
Grant date	Oct 21, 2025

Abstract

The invention relates to a system for carrying out dialysis treatment with a dialysis machine, a control unit and a sensor, the sensor being signal-connected to the control unit, and the control unit being designed to measure a patient's blood sugar level or interstitial glucose value during dialysis treatment using the sensor, to record a curve over time of the blood sugar level or interstitial glucose values on the basis of the measured values, and to adapt one or more treatment parameters of the dialysis machine automatically taking the curve into account, or to output an instruction for adaptation of a treatment parameter by a user or for another action by a user.

First claim

The invention claimed is:

1. A system configured for carrying out a plurality of peritoneal dialysis treatments on a patient, the system comprising a peritoneal dialysis machine, a control unit, and a sensor, wherein
the sensor is in signal communication with the control unit,
the peritoneal dialysis machine is configured to carry out, for each peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments, a respective plurality of peritoneal dialysis cycles during the respective peritoneal dialysis treatment, each cycle of each respective plurality of peritoneal dialysis cycles comprising an inflow phase, a dwell phase, and an outflow phase, wherein:
for each peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments
each inflow phase of the respective plurality of peritoneal dialysis cycles comprises administering to the patient a respective dialysis solution having a respective composition including a respective glucose concentration, the respective dialysis solution being supplied to the peritoneal dialysis machine,
each dwell phase of the respective plurality of peritoneal dialysis cycles lasts for a respective dwell time, and
the respective plurality of peritoneal dialysis cycles comprises an initial cycle and a subsequent cycle;

for each peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments, the control unit is configured to
administer to the patient a first dialysis solution during the inflow phase of the respective initial cycle, the first dialysis solution having a first composition including a first glucose concentration,
control the dwell time of the respective initial cycle to be a first dwell time,
measure, with the sensor, over time, a blood glucose level or an interstitial glucose value, of the patient, during at least one cycle of the respective plurality of peritoneal dialysis cycles, to obtain measurement values, and
record a respective time progression of the blood glucose level or of the interstitial glucose values on the basis of the obtained measurement values, by plotting a curve of the measurement values over time; and

the control unit is configured to
adapt one or more treatment parameters of the peritoneal dialysis machine, for a subsequent peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments, based on the respective recorded time progression recorded for a past peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments, wherein the adapting the one or more treatment parameters comprises (i) controlling the peritoneal dialysis machine to administer a second dialysis solution to the patient during the respective subsequent cycle of the respective plurality of peritoneal dialysis cycles of the subsequent peritoneal dialysis treatment, the second dialysis solution having a second glucose concentration that differs from the first glucose concentration, (ii) automatically controlling the dwell time of the dwell phase of the respective subsequent cycle of the respective plurality of peritoneal dialysis cycles of the subsequent peritoneal dialysis treatment, to be a second dwell time that differs from the first dwell time, or (iii) both (i) and (ii).

2. The system in accordance with claim 1 , wherein the control unit is further configured to obtain body fluid status information on a body fluid status of the patient during a first peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments on the patient, and to either (i) adapt a treatment parameter of the peritoneal dialysis machine for a subsequent peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments on the patient, based on the body fluid status information, or (ii) output the body fluid status information to an external device.

3. The system in accordance with claim 1 , wherein the control unit is configured to adapt one or more treatment parameters of the peritoneal dialysis machine for a subsequent peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments, based on the recorded time progression recorded for a past peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments, by
controlling the peritoneal dialysis machine to administer a second dialysis solution to the patient during the subsequent cycle of the respective plurality of peritoneal dialysis cycles of the subsequent peritoneal dialysis treatment, the second dialysis solution having a second glucose concentration that differs from the first glucose concentration.

4. The system in accordance with claim 1 , wherein the control unit is configured to adapt one or more treatment parameters of the peritoneal dialysis machine for a subsequent peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments, based on the recorded time progression recorded for a past peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments, by automatically controlling the dwell time of the dwell phase of the subsequent cycle of the respective plurality of peritoneal dialysis cycles of the subsequent peritoneal dialysis treatment, to be a second dwell time that differs from the first dwell time.

5. The system in accordance with claim 1 , wherein the system furthermore comprises an apparatus for administering insulin, administering a diuretic, or administering both, to the patient, and the control unit is configured to administer, during the subsequent peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments, insulin, a diuretic, or both, to the patient, based on a continuous determination of a glucose content in blood or of an interstitial glucose value.

6. The system in accordance with claim 1 , wherein the control unit is configured to output instructions for a user-side adaptation of a treatment parameter for a subsequent peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments, and either: (i) display the instructions for the user-side adaptation of the treatment parameter, at a user interface; or (ii) to transmit the instructions for the user-side adaptation of the treatment parameter, to an external device.

7. The system in accordance with claim 1 , wherein
the control unit is configured to measure, with the sensor, over time, the interstitial glucose value of a patient during a first peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments carried out on the patient with the peritoneal dialysis machine, to obtain measurement values,
the measurement values are interstitial glucose values, and
the recorded time progression is a recorded time progression of the interstitial glucose values.

8. The system in accordance with claim 1 , wherein
the control unit is configured to measure, with the sensor, over time, the blood glucose level of patient during a first peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments carried out on the patient with the peritoneal dialysis machine, to obtain measurement values,
the measurement values are blood glucose level values, and
the recorded time progression is a recorded time progression of the blood glucose level values.

9. The system in accordance with claim 5 , wherein
the control unit is configured to measure, with the sensor, over time, the interstitial glucose value of a patient during a first peritoneal dialysis treatment of the plurality of peritoneal dialysis treatments carried out on the patient with the peritoneal dialysis machine, to obtain measurement values,
the measurement values are interstitial glucose values,
the recorded time progression is a recorded time progression of the interstitial glucose values, and

Assignees

• Fresenius Medical Care Deutschland Gmbh

Inventors

• Wabel Peter

Classifications

• A61M2230/201

  Glucose concentration · CPC title

• A61M1/28

  Peritoneal dialysis {; Other peritoneal treatment, e.g. oxygenation} · CPC title

• A61M1/14 Primary

  Dialysis systems; Artificial kidneys; Blood oxygenators (semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00){; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis} · CPC title

• A61M1/1621 Primary

  Constructional aspects thereof (semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi permeable membranes characterised by their material B01D71/00) · CPC title