Multi-unit drug delivery devices and methods

Patent metadata

Field	Value
Publication number	US-12447241-B2
Application number	US-202016936554-A
Country	US
Kind code	B2
Filing date	Jul 23, 2020
Priority date	Aug 19, 2013
Publication date	Oct 21, 2025
Grant date	Oct 21, 2025

Abstract

Implantable drug delivery devices include a housing defining a reservoir, a first unit within the reservoir, and a second unit within the reservoir. The first unit contains a drug and the second unit contains a functional agent that facilitates release of the drug. Intravesical drug delivery devices include a housing portion containing a drug formulation and a housing portion containing an excipient, and are configured to release the drug according to a first release profile and the excipient according to a second release profile. Methods include inserting any of these devices into a patient and releasing drug from the device.

First claim

We claim:

1. A drug formulation consisting of:
a first plurality of mini-tablets each consisting of:
80.0% by weight gemcitabine HCI;
13.3% by weight urea;
4.2% by weight polyvinylpyrrolidone; and
2.5% by weight polyethylene glycol 8000; and

a second plurality of mini-tablets each consisting of:
90% by weight urea; and
10% by weight one or more excipients.

2. The drug formulation of claim 1 , wherein each of the first and second pluralities of mini-tablets has a diameter between 1.5 mm and 3.1 mm.

3. The drug formulation of claim 2 , wherein each of the first and second pluralities of mini-tablets has a length between 2.0 mm and 4.5 mm.

4. The drug formulation of claim 1 , wherein each of the first and second pluralities of mini-tablets has a diameter of about 2.64 mm.

5. The drug formulation of claim 4 , wherein each of the first and second pluralities of mini-tablets has a length between 2.0 mm and 4.5 mm.

6. The drug formulation of claim 5 , wherein each of the first and second pluralities of mini-tablets has an aspect ratio of height: width of 3:2.

7. The drug formulation of claim 1 , wherein each of the first and second pluralities of mini-tablets has an aspect ratio of height: width from 3:2 to 5:2.

Assignees

• Taris Biomedical Llc

Inventors

• Lee Heejin
• Daniel Karen
• Sansone Matthew

Classifications

• A61K9/0092

  Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes · CPC title

• A61K9/0034

  Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants · CPC title

• A61K9/0004 Primary

  Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas · CPC title

• A61M31/002

  Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time (artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50) · CPC title

• A61L31/048

  obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence) · CPC title