System and method for producing fluid for peritoneal dialysis

Patent metadata

Field	Value
Publication number	US-12440614-B2
Application number	US-202117798114-A
Country	US
Kind code	B2
Filing date	Feb 5, 2021
Priority date	Feb 6, 2020
Publication date	Oct 14, 2025
Grant date	Oct 14, 2025

Abstract

A system for producing fluid for peritoneal dialysis (PD) is disclosed. The system includes a fluid path including two or more PD concentrate connectors that are each connected to a source of PD concentrate fluid, and an inlet connector connected to a fluid line arranged for transportation of effluent fluid from a patient. The system also includes a forward osmosis (FO)-unit including a draw side and a feed side separated by a FO-membrane. The FO-unit is fluidly connected to the fluid path and receives one or more PD concentrate fluids at the draw side and the effluent at the feed side. Water is transported from the effluent to the one or more PD concentrate fluids through the FO-membrane via an osmotic pressure gradient between the draw side and the feed side, thereby diluting the one or more PD concentrate fluids into a diluted PD concentrate fluid.

First claim

The invention claimed is:

1. A system for producing fluid for peritoneal dialysis (PD), the system comprising:
a fluid path including one or more PD-concentrate connectors each connector configured to be connected to a source of PD concentrate fluid, an inlet connector configured to be connected to a fluid line arranged for transportation of effluent fluid from a patient;
a forward osmosis (FO)-unit including a draw side and a feed side separated by a FO-membrane, the FO-unit fluidly connected to the fluid path, wherein the FO-unit is configured to receive one or more PD concentrate fluids at the draw side and to receive the effluent at the feed side, wherein water is transported from the effluent to the one or more PD concentrate fluids through the FO-membrane via an osmotic pressure gradient between the draw side and the feed side, thereby diluting the one or more PD concentrate fluids into a diluted PD concentrate fluid, wherein the fluid path includes a circulation fluid path for circulating the diluted PD concentrate fluid;
a concentration sensor configured to sense the concentration of the diluted PD concentrate fluid; and
a control arrangement configured to
control a flow rate of effluent fluid into the feed side, and control a flow rate of the one or more PD concentrate fluids into the draw side based on a desired composition of a final PD fluid, a concentration of the one or more PD concentrate fluids, an amount of effluent at hand, and a time available for an FO session to yield the diluted PD concentrate fluid,
circulate the diluted PD concentrate fluid in the circulation fluid path until a mixing criterion for the diluted PD concentrate fluid is fulfilled based on the sensed concentration by the concentration sensor, and
control a flow rate of a second or third concentrate into the diluted PD concentrate fluid to form the final PD fluid.

2. The system according to claim 1 , wherein the control arrangement is configured to perform (i) the control of the flow rate of effluent fluid into the feed side, and (ii) the control of the flow rate of the one or more PD concentrate fluids to yield the diluted PD concentrate fluid prior to treatment.

3. The system according to claim 1 , wherein the control arrangement includes a first pump configured to pump the one or more PD concentrate fluids into the draw side.

4. The system according to claim 1 , wherein the control arrangement is configured such that transportation of effluent fluid from a patient for storage is performed prior to treatment.

5. The system according to claim 3 , including a second pump configured to pump the second or third concentrate, which may include an osmotic agent.

6. The system according to claim 1 , wherein the fluid path includes a water source connector downstream of the FO-unit, the water source connector configured to be connected to a source of purified water, and wherein the control arrangement is configured to cause purified water from the source of purified water to be supplied to the diluted PD concentrate fluid to achieve a prescribed composition of the final PD fluid.

7. The system according to claim 6 , which is configured to sense a concentration of the final PD fluid, wherein the control arrangement is configured to control the flow rate of the diluted one or more PD concentrate fluids and the second or third concentrate to achieve the prescribed composition of the final PD fluid based on the sensed concentration of the final PD fluid.

8. The system according to claim 1 , further including a system pump configured to pump a flow rate of the final PD fluid.

9. The system according to claim 1 , further including a diluted PD concentrate container fluidly connected or connectable to the fluid path,
wherein the diluted PD concentrate container is arranged to receive the diluted PD concentrate fluid, and
wherein the diluted PD concentrate container is optionally initially partially filled with purified water.

10. The system according to claim 1 , further including an effluent pump configured to pump the flow rate of effluent fluid into the feed side.

11. The system according to claim 1 , further including a heater configured to heat the fluid in the fluid path.

12. The system according to claim 1 , further including an effluent container fluidly connected to the fluid path and the inlet connector, wherein the effluent container is arranged to collect effluent fluid received from the patient before it is transported into the feed side.

13. The system according to claim 1 , wherein the one or more PD concentrate fluids includes a fluid including one or more of lactate, acetate, citrate, bicarbonate, NaCl, MgCl2, CaCl2, or KCl.

14. The system according to claim 1 , wherein one of the PD concentrate fluids includes a higher concentrated component solution than the component solution in a fully mixed version of the PD concentrate, and the other of the PD concentrate fluids includes a remainder of the concentrate.

15. The system according to claim 1 , which is a continuous flow peritoneal dialysis (CFPD) system, and which further includes a drain pump positioned and arranged to pump effluent from a patient to a location for delivery to the feed side of the FO-unit.

16. The system according to claim 9 , wherein the control arrangement includes the first pump configured to pump diluted one or more PD concentrate fluids from the diluted PD concentrate container and a second PD concentrate pump configured to pump the one or more PD concentrate fluids into the draw side of the FO-unit.

17. The system according to claim 1 , which further includes a line and a valve positioned and arranged to enable initially but not completely diluted PD concentrate fluid to be redirected for delivery to the feed side of the FO-unit.

18. The system according to claim 1 , which further includes a device configured and arranged to create a higher pressure on the feed side of the FO-unit than the draw side.

19. A method for producing fluid for peritoneal dialysis (PD) in a system including a forward osmosis-(FO-) unit including a draw side and a feed side separated by a FO-membrane, the FO-unit configured to receive one or more PD concentrate fluids at the draw side and effluent fluid from a PD patient at the feed side to transport water from the effluent to the one or more PD concentrate fluids through the FO-membrane by means of an osmotic pressure gradient between the draw side and the feed side, and thereby diluting the one or more PD concentrate fluids into a diluted PD concentrate fluid, the method including:
controlling a flow rate of the effluent fluid into the feed side of the FO-unit;
controlling a flow rate of the one or more PD concentrate fluids into the draw side based on a desired composition of a final PD fluid, a concentration of the one or more concentrate fluids, an amount of effluent at hand and a time available for an FO session to yield the diluted PD concentrate fluid;
sensing a concentration of the diluted PD concentrate fluid;
circulating the diluted PD concentrate fluid in the circulation fluid path until a mixing criterion for the diluted PD concentrate fluid is fulfilled based on the sensed concentration of the diluted PD concentrate fluid; and
controlling a flow rate of a second or third concentrate into the diluted PD concentrate fluid to form a final PD fluid.

20. The method according to claim 19 , wherein the flow rate of the effluent and the flow rate of the one or more PD concentrate fluids is performed prior to treatment

Assignees

• Gambro Lundia Ab

Inventors

• Vartia Christian
• Lindgren Henrik
• Borgqvist Per-Olof
• Jansson Olof

Classifications

• B01D61/002

  Forward osmosis or direct osmosis · CPC title

• A61M1/284

  Continuous flow peritoneal dialysis [CFPD] · CPC title

• A61M1/1672 Primary

  using membrane filters, e.g. for sterilising the dialysate · CPC title

• A61M1/287 Primary

  Dialysates therefor · CPC title

• A61M1/282

  Operational modes · CPC title