Gas delivery devices

Patent metadata

Field	Value
Publication number	US-12434033-B2
Application number	US-201917279448-A
Country	US
Kind code	B2
Filing date	Sep 27, 2019
Priority date	Sep 27, 2018
Publication date	Oct 7, 2025
Grant date	Oct 7, 2025

Abstract

Gas delivery devices include different examples of nitric oxide (NO) generating systems. Each example of the NO generating system includes a solid, light sensitive NO donor, and a light source that is operatively positioned to selectively expose the solid, light sensitive NO donor to light in order to generate NO gas.

First claim

What is claimed is:

1. A gas delivery device, comprising:
a nitric oxide (NO) generating system, including:
a chamber having interior and exterior surfaces;
an NO cartridge contained within the chamber, the NO cartridge including:
a substrate;
a solid, light sensitive NO donor immobilized on a surface of the substrate; and
an NO permeable and light transparent membrane positioned on the solid, light sensitive NO donor; and

a light source attached to either i) the exterior surface or ii) the interior surface and spaced from the NO cartridge, wherein the light source is operatively positioned on the exterior or interior surface to selectively expose the solid, light sensitive NO donor to light to generate NO gas;

an inspiratory gas conduit operatively connected to the chamber to introduce an oxygen-containing gas and form an output gas including the NO gas; and
an outlet conduit to transport a stream of the output gas from the NO generating system.

2. The gas delivery device as defined in claim 1 wherein the NO permeable and light transparent membrane is a nanoporous membrane or a microporous membrane including polycarbonate.

3. The gas delivery device as defined in claim 1 wherein the solid, light sensitive NO donor is a light sensitive S-nitrosothiol.

4. The gas delivery device as defined in claim 3 wherein the light sensitive S-nitrosothiol is selected from the group consisting of S-nitroso-N-acetyl-penicillamine crystals, S-nitrosoglutathione crystals, and combinations thereof.

5. The gas delivery device as defined in claim 1 wherein the solid, light sensitive NO donor is immobilized on the substrate by a pressure sensitive adhesive.

6. The gas delivery device as defined in claim 1 , further comprising:
a sensor in contact with the output gas stream to monitor a nitric oxide level of the output gas stream; and
a controller operatively connected to the sensor and to the light source, the controller to adjust a parameter of the light source in response to the nitric oxide level from the sensor.

7. The gas delivery device as defined in claim 1 , further comprising:
a delivery conduit operatively connected to the outlet conduit; and
an inhalation unit operatively connected to a delivery conduit and selected from the group consisting of a ventilator, a face mask, and a nasal cannula.

8. The gas delivery device as defined in claim 7 , further comprising a nitrogen dioxide filter positioned in the delivery conduit to receive the output gas stream before it is delivered to the inhalation unit.

9. The gas delivery device as defined in claim 1 wherein the light from the light source is to initiate photolysis of the solid, light sensitive NO donor.

10. The gas delivery device as defined in claim 9 wherein the light source has a nominal wavelength ranging from about 300 nm to about 600 nm.

11. The gas delivery device as defined in claim 1 wherein an NO 2 level in the output gas is less than 1 parts per million by volume (ppmv).

12. The gas delivery device as defined in claim 1 wherein the solid, light sensitive NO donor is immobilized in a cavity formed on the substrate.

13. A gas delivery device, comprising:
a nitric oxide (NO) generating system, including:
a NO cartridge contained within the chamber, the NO cartridge including:
a substrate having first and second surfaces;
a solid, light sensitive NO donor immobilized on a surface of the substrate; and
an NO permeable and light transparent membrane positioned on the solid, light sensitive NO donor; and

a light source operatively positioned to selectively expose the solid, light sensitive NO donor to light to generate NO gas;

an inspiratory gas conduit operatively connected to the chamber to introduce an oxygen-containing gas and form an output gas including the NO gas; and
an outlet conduit to transport a stream of the output gas from the NO generating system,
wherein:
the solid, light sensitive NO donor and the NO permeable and light transparent membrane are positioned on the first surface of the substrate;
the NO cartridge further includes:
a second solid, light sensitive NO donor immobilized on the second surface of the substrate; and
a second NO permeable and light transparent membrane positioned on the second solid, light sensitive NO donor; and

the NO generating system further includes a second light source operatively positioned to selectively expose the second solid, light sensitive NO donor to light to generate additional NO gas.

14. A gas delivery device, comprising:
a nitric oxide (NO) generating system, including:
a chamber having interior and exterior surfaces;
an NO cartridge contained within the chamber, the NO cartridge including:
a light transparent substrate;
a solid, light sensitive NO donor immobilized on a surface of the light transparent substrate;
a light transparent adhesive sandwiched between the light transparent substrate and the solid, light sensitive NO donor; and
a porous membrane positioned on the solid, light sensitive NO donor; and

a light source attached to either i) the exterior surface or ii) the interior surface and spaced from the NO cartridge, wherein the light source is operatively positioned on the exterior or interior surface to selectively expose the solid, light sensitive NO donor to light through the light transparent substrate to generate NO gas;

an inspiratory gas conduit operatively connected to the chamber to introduce an oxygen-containing gas and form an output gas including the NO gas; and
an outlet conduit to transport a stream of the output gas from the NO generating system.

15. The gas delivery device as defined in claim 14 wherein an NO 2 level in the output gas is less than 1 parts per million by volume (ppmv).

16. A gas delivery device, comprising:
a nitric oxide (NO) generating system, including:
a vacuum environment;
an NO cartridge contained within the vacuum environment, the NO cartridge including:
a substrate; and
a solid, light sensitive NO donor immobilized on or in the substrate; and

a light source operatively positioned to selectively expose the solid, light sensitive NO donor to light to generate NO gas; and

an outlet conduit to transport a stream of the NO gas from the NO generating system; and
an inspiratory gas conduit operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.

17. The gas delivery device as defined in claim 16 wherein the solid, light sensitive NO donor is immobilized on the substrate with an adhesive, and wherein the NO cartridge further includes a membrane positioned on the solid, light sensitive NO donor, the membrane being NO permeable and transparent to the light.

18. The gas delivery device as defined in claim 17 wherein the membrane is nanoporous or microporous.

19. The gas delivery device as defined in claim 18 wherein the membrane is a polycarbonate membrane.

20. The gas delivery device as defined in claim 16 wherein the solid, light sensitive NO donor is immobilized in a cavity formed on the substrate.

21. The gas delivery device as defined in claim 16 , further comprising:
a sensor in contact with the output gas stream to monitor a nitric oxide level of the output gas stream; and
a controller operatively connected to the sensor and to the light source, the controller to adjust a parameter of the light source in response to the nitric oxide level from the sensor.

22.

Assignees

• Univ Michigan Regents

Inventors

• Lautner Gergely
• Stringer Blake
• Brisbois Elizabeth J
• Meyerhoff Mark E
• Schwendeman Steven P

Classifications

• A61M2205/587

  Lighting arrangements · CPC title

• A61M16/024 Primary

  including calculation means, e.g. using a processor · CPC title

• A61M2202/0275

  Nitric oxide [NO] · CPC title

• A61M2016/102

  Measuring a parameter of the content of the delivered gas · CPC title

• A61M16/105

  Filters (A61M16/047, A61M16/22 take precedence; water traps A61M16/08) · CPC title