Ang (1-7) derivative oligopeptides and methods for using and producing the same
US-12116423-B2 · Oct 15, 2024 · US
Ang (1-7) derivative oligopeptides for the treatment of pain
US12433932B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12433932-B2 |
| Application number | US-202318151957-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 9, 2023 |
| Priority date | Jul 21, 2014 |
| Publication date | Oct 7, 2025 |
| Grant date | Oct 7, 2025 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and pain.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for treating a painful condition in a subject comprising administering a therapeutically effective amount of an oligopeptide having the formula: A 1 -A 2 -A 3 -A 4 -A 5 -A 6 -A 7 -A 8 (SEQ ID NO:10) wherein A 1 is aspartic acid; A 2 is arginine; A 3 is valine; A 4 is tyrosine; A 5 is isoleucine; A 6 is histidine; A 7 is serine; and A 8 is absent, wherein the painful condition is selected from the group consisting of acute pain, trauma-induced pain, dental pain, and osteoarthritis, wherein the oligopeptide is glycosylated with a monosaccharide or disaccharide.
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Classifications
the peptide sequence having less than 12 amino acids and not being part of a ring structure · CPC title
Angiotensins: Related peptides · CPC title
having 5 to 11 amino acids · CPC title
- A61K38/085Primary
Angiotensins · CPC title
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- What does patent US12433932B2 cover?
- The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications i…
- Who is the assignee on this patent?
- Univ Arizona
- What technology area does this patent fall under?
- Primary CPC classification A61K38/085. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 07 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).