Cyclophane-sustained high performance porphyrins
US-12084579-B2 · Sep 10, 2024 · US
Supramolecular photoprotection of a photosensitizer
US12433870B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12433870-B2 |
| Application number | US-202017426633-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 31, 2020 |
| Priority date | Jan 31, 2019 |
| Publication date | Oct 7, 2025 |
| Grant date | Oct 7, 2025 |
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- Title
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- Abstract
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Abstract
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Disclosed herein are compositions comprising a water-soluble host-guest complex formed from a host receptor and a guest photosensitizer for the photoprotection of the photosensitizer. Also disclosed are methods of using the composition for generating reactive oxygen species, inhibiting the proliferation or killing of a cell, treating a subject with a cell proliferative disease or disorder.
First claim
Opening claim text (preview).
We claim: 1. A pharmaceutical composition comprising water-soluble host-guest complex formed from a host receptor and a guest photosensitizer, wherein the photosensitizer comprises a macrocyclic pyrrole, wherein the receptor host is a cyclophane, and one or more pharmaceutically acceptable carriers, excipients, or diluents, wherein the pharmaceutical composition comprises an effective amount of the guest photosensitizer for treating a cell proliferative disease or disorder. 2. The pharmaceutical composition of claim 1 , wherein the cell proliferative disease or disorder is a cancer. 3. The pharmaceutical composition of claim 1 , wherein the cell proliferative disease or disorder is a microbial infection. 4. The pharmaceutical composition of claim 1 , wherein the macrocylic pyrrole is a porphyrin, a chlorin, a bacteriochlorin, a phthalocyanine, a napthalocyanine, or a subphthalocyanine. 5. The pharmaceutical composition of claim 1 , wherein the cyclophane comprises two extended viologen units and two linker units having an ordered, cyclic arrangement alternating between extended viologen unit and linker unit. 6. The pharmaceutical composition of claim 1 , wherein the host receptor comprises
Assignees
Inventors
Classifications
in which the condensed system contains four or more hetero rings · CPC title
Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent · CPC title
Antineoplastic agents · CPC title
- A61K31/409Primary
having four such rings, e.g. porphine derivatives, bilirubin, biliverdine (hemin, hematin A61K31/555) · CPC title
- A61P31/00Primary
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title
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- What does patent US12433870B2 cover?
- Disclosed herein are compositions comprising a water-soluble host-guest complex formed from a host receptor and a guest photosensitizer for the photoprotection of the photosensitizer. Also disclosed are methods of using the composition for generating reactive oxygen species, inhibiting the proliferation or killing of a cell, treating a subject with a cell proliferative disease or disorder.
- Who is the assignee on this patent?
- Univ Northwestern, King Abdulaziz City For Science And Tech Kacst
- What technology area does this patent fall under?
- Primary CPC classification A61K31/409. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 07 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).