Devices, systems, and methods for biological sample collection

Patent metadata

Field	Value
Publication number	US-12433787-B2
Application number	US-202017612156-A
Country	US
Kind code	B2
Filing date	May 21, 2020
Priority date	May 21, 2019
Publication date	Oct 7, 2025
Grant date	Oct 7, 2025

Abstract

A device comprising a syringe comprising a plunger and a barrel having a longitudinal axis and a sample collection volume. The device further comprises a needle hub including an attachment device for connection with the syringe, and a syringe support connected to the needle hub. A needle is connected to the needle hub, the needle having a lumen. An internal needle is at least partially positioned within the lumen of the needle. The device further includes a motor that rotationally moves the internal needle within the needle. The needle has a first opening formed in a side of the needle, and the internal needle has a second opening formed in a side of the internal needle; and wherein material is allowed to enter when the second opening is aligned with the first opening, and wherein the material is cut when the second opening rotates past the first opening.

First claim

We claim:

1. A device comprising:
a syringe comprising a plunger and a barrel having a longitudinal axis and a sample collection volume;
a needle hub including an attachment device for connection with the syringe;
wherein the syringe is connected to the needle hub;
a syringe support connected to the needle hub; wherein the syringe support comprises a compartment, a power button, and a power indicator;
a microcontroller positioned within the compartment;
a needle connected to the needle hub, the needle having a lumen;
an internal needle at least partially positioned within the lumen of the needle; wherein the internal needle is hollow; and
a motor that rotationally moves the internal needle within the needle; wherein the motor includes one or more permanent magnets positioned inside of the needle hub and coupled to the internal needle; and wherein the motor further includes a stator with a plurality of coils mounted outside the needle hub; and
wherein the needle has a first opening formed in a side of the needle, and the internal needle has a second opening formed in a side of the internal needle; and wherein material is allowed to enter when the second opening is aligned with the first opening, and wherein the material is cut when the second opening rotates past the first opening.

2. The device of claim 1 , wherein the plurality of coils are positioned around the longitudinal axis.

3. The device of claim 1 , wherein the motor is positioned outside of the barrel.

4. The device of claim 1 , further comprising a battery positioned within the compartment.

5. The device of claim 1 , wherein the syringe is removably connected to the needle hub.

6. The device of claim 1 , wherein the needle is 20 gauge or smaller.

7. The device of claim 1 , further comprising a separator that separates the one or more permanent magnets from the syringe, while allowing the inner needle to pass through to transfer a sample to the barrel.

8. The device of claim 1 , further comprising a pivoting platform in contact with the one or more permanent magnets.

9. The device of claim 1 , wherein the device is provided as a sterile, single-use component.

10. The device of claim 1 , wherein the motor rotationally moves the internal needle at a constant speed.

11. A system comprising the device of claim 1 and a biological sample collected in the barrel.

12. The system of claim 11 , wherein the biological sample collected is less than 1 mL.

13. The system of claim 12 , wherein the biological sample collected is less than 250 μL.

14. The system of claim 11 , wherein the biological sample is a vitreous sample.

15. A method comprising:
collecting a biological sample with the device of claim 1 wherein the method comprises:
a) positioning a distal end of the needle into a region containing the biological sample to be collected;
b) engaging the power button and activating the motor to move the internal needle; and
c) drawing the biological sample into the sample collection volume.

16. The method of claim 15 , further comprising analyzing the biological sample.

17. The method of claim 16 , wherein analyzing the biological sample comprises detecting biomarkers related to one or more disease or condition.

18. The method of claim 15 , wherein the biological sample is a vitreous sample.

19. The method of claim 15 , further comprising disposing the device after collecting the biological sample.

20. The method of claim 15 , wherein drawing the biological sample into the sample collection volume comprises drawing less than 1 mL of the biological sample.

21. The method of claim 15 , wherein drawing the biological sample into the collection volume comprises manually actuating the plunger with one hand while holding the device with another hand.

22. The method of claim 15 , wherein collecting the biological sample is performed by a single operator with two hands.

23. The method of claim 15 , wherein collecting the biological sample with the device is not performed in an operating room.

24. A device comprising:
a syringe comprising a plunger and a barrel having a longitudinal axis and a sample collection volume;
a needle hub including an attachment device for connection with the syringe;
wherein the syringe is connected to the needle hub;
a syringe support connected to the needle hub; wherein the syringe support comprises a compartment;
a microcontroller positioned within the compartment;
a needle connected to the needle hub, the needle having a lumen;
an internal needle at least partially positioned within the lumen of the needle;
wherein the internal needle is hollow; and
a motor that rotationally moves the internal needle within the needle; wherein the motor includes one or more permanent magnets positioned inside of the needle hub and coupled to the internal needle; and wherein the motor further includes a stator with a plurality of coils mounted outside the needle hub; and
wherein the needle has a first opening formed in a side of the needle, and the internal needle has a second opening formed in a side of the internal needle; and wherein material is allowed to enter when the second opening is aligned with the first opening, and wherein the material is cut when the second opening rotates past the first opening;
wherein the device is provided as a sterile, single-use component.

Assignees

• Univ Michigan Regents
• Penn State Res Found

Inventors

• Ojeda Lauro V
• Sundstrom Jeffrey M
• Holmer Justin T
• Cruz Alan
• Huang Minghui
• Bhamri Anant
• Demirci Hakan
• Gardner Thomas
• Miller Russ
• Nguyen Peter

Classifications

• A61B2010/0208

  Biopsy devices with actuators, e.g. with triggered spring mechanisms · CPC title

• A61B2010/0067

  Tear or lachrymal fluid · CPC title

• A61B10/0233

  Pointed or sharp biopsy instruments · CPC title

• A61B10/0045 Primary

  Devices for taking samples of body liquids · CPC title

• A61F9/00763 Primary

  with rotating or reciprocating cutting elements, e.g. concentric cutting needles (atherectomy cutting instruments A61B17/3207; endoscopic cutting instruments A61B17/320016) · CPC title