Heart valve mimicry

Patent metadata

Field	Value
Publication number	US-12433745-B2
Application number	US-202117643988-A
Country	US
Kind code	B2
Filing date	Dec 13, 2021
Priority date	Jan 27, 2017
Publication date	Oct 7, 2025
Grant date	Oct 7, 2025

Abstract

This disclosure relates to a heart valve with improved functionality and durability.

First claim

The invention claimed is:

1. A method for implanting a heart valve prosthesis at a native heart valve of a patient, the method comprising:
loading the heart valve prosthesis in a collapsed shape onto a delivery catheter, the heart valve prosthesis comprising (i) a stent comprising at least one feeler designed to align the stent with the native heart valve and an outflow end region comprising a first cell and a second cell, and (ii) a valve prosthesis coupled to the stent having a valve ratio of annulus to commissure distance (ACD) to annulus diameter (AD) of 1.01 to 1.14, the ACD distance being a distance between a proximal end of a commissure portion and a proximal end of an annulus portion, wherein in the outflow end region aspect ratios of the first cell and the second cell in a single circumferential row vary with respect to one another from 1 to 3, areas of the first cell and the second cell vary with respect to one another from 5 mm 2 to 250 mm 2 or heights of the first cell and the second cell vary with respect to one another from 3 mm to 30 mm;
delivering the heart valve prosthesis to the native heart valve via vasculature of the patient;
positioning the heart valve prosthesis at the native valve by protruding the at least one feeler to align the heart valve prosthesis with endogenous commissures of the native heart valve; and
deploying the heart valve prosthesis at the native valve such that the heart valve prosthesis transforms to an expanded shape.

2. The method of claim 1 , wherein positioning the heart valve prosthesis at the native heart valve comprises positioning the at least one feeler within at least one native cusp of the native heart valve.

3. The method of claim 1 , wherein the stent comprises three feelers.

4. The method of claim 1 , wherein the stent comprises a fastening portion designed for coupling the valve prosthesis to the stent.

5. The method of claim 4 , wherein the fastening portion comprises at least one notch, hole or rail designed to secure the valve prosthesis to the stent.

6. The method of claim 1 , wherein the stent comprises an inflow end region, the inflow end region comprising a lower elasticity than the outflow end region.

7. The method of claim 6 , wherein the outflow end region is designed to reduce its diameter in an implanted state.

8. The method of claim 1 , wherein the valve prosthesis comprises pericardial tissue.

9. The method of claim 1 , further comprising retracting the catheter from the patient's vasculature.

10. A method for implanting a heart valve prosthesis at a native heart valve of a patient, the method comprising:
loading the heart valve prosthesis in a collapsed shape onto a delivery catheter, the heart valve prosthesis comprising (i) a stent comprising at least one feeler designed to align the stent with the native heart valve and an inflow region and an outflow region each comprising a plurality of cells, and (ii) a valve prosthesis coupled to the stent having a valve ratio of annulus to commissure distance (ACD) to annulus diameter (AD) of 1.01 to 1.14, the ACD distance being a distance between a proximal end of a commissure portion and a proximal end of an annulus portion, wherein a number of cells per cm 2 area is 2 to 6 in the inflow region and 1 to 4 in the outflow end region;
delivering the heart valve prosthesis to the native heart valve via vasculature of the patient;
positioning the heart valve prosthesis at the native valve by protruding the at least one feeler to align the heart valve prosthesis with endogenous commissures of the native heart valve; and
deploying the heart valve prosthesis at the native valve such that the heart valve prosthesis transforms to an expanded shape.

11. The method of claim 10 , wherein positioning the heart valve prosthesis at the native heart valve comprises positioning the at least one feeler within at least one native cusp of the native heart valve.

12. The method of claim 10 , wherein the stent comprises three feelers.

13. The method of claim 10 , wherein the stent comprises a fastening portion designed for coupling the valve prosthesis to the stent.

14. The method of claim 13 , wherein the fastening portion comprises at least one notch, hole or rail designed to secure the valve prosthesis to the stent.

15. The method of claim 10 , wherein the stent comprises an inflow end region, the inflow end region comprising a lower elasticity than the outflow end region.

16. The method of claim 15 , wherein the outflow end region is designed to reduce its diameter in an implanted state.

17. The method of claim 10 , wherein the valve prosthesis comprises pericardial issue.

18. The method of claim 10 , further comprising retracting the catheter from the patient's vasculature.

Assignees

• Jenavalve Tech Inc

Inventors

• Saffari Payam
• Chow Vincent Ming Hai
• Lordeus Makensley
• Rangwala Hussain S
• Mirigian Gregory Edwin
• Migliazza John F
• Carr-Brendel Victoria E

Classifications

• A61F2250/0025

  differing in roughness · CPC title

• A61F2220/0008

  Fixation appliances for connecting prostheses to the body · CPC title

• A61F2250/0097

  Visible markings, e.g. indicia · CPC title

• A61F2250/0039

  differing in diameter · CPC title

• A61F2220/0075

  sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable · CPC title