Cooling fluid flow rate monitoring for laser interstitial thermal therapy

Patent metadata

Field	Value
Publication number	US-12433674-B2
Application number	US-202217929971-A
Country	US
Kind code	B2
Filing date	Sep 6, 2022
Priority date	Oct 14, 2021
Publication date	Oct 7, 2025
Grant date	Oct 7, 2025

Abstract

Devices, systems, and methods to verify a magnetic field phase drift and to check for proper function of a laser fiber cooling system during laser ablation therapy are disclosed. The laser fiber cooling system includes a cooling catheter insertable into laser ablation target tissue, a coupling assembly to define fluid channels, inflow and outflow ports, a fluid pump to pump fluid through the laser fiber cooling system, a fluid source, a first sensor to measure an inflow fluid parameter, a second sensor to measure an outflow fluid parameter, and a processor. Methods of verifying and checking include measuring the fluid parameter, comparing the inflow and outflow parameter measurements to determine a comparison value, comparing the comparison value to a tolerance range, and signaling a user when the comparison value is outside of the tolerance range.

First claim

The invention claimed is:

1. A laser fiber cooling monitoring system, comprising:
a cooling catheter extending a length from a proximal end of the cooling catheter to a distal end of the cooling catheter, the cooling catheter comprising:
an inflow port disposed adjacent the proximal end;
an outflow port disposed adjacent the proximal end; and
a fluid flow path comprising a first fluid flow channel extending from the inflow port to a point inside the cooling catheter adjacent the distal end and a second fluid flow channel extending from the point inside the cooling catheter adjacent the distal end to the outflow port;

a cooling fluid source comprising a container that contains a cooling fluid;
an inflow channel arranged in fluid communication with the cooling fluid source, the inflow port, and the first fluid flow channel;
an outflow channel arranged in fluid communication with the outflow port and the second fluid flow channel;
a first sensor arranged at a point along a length of the inflow channel between the inflow port and the cooling fluid source, wherein the first sensor measures a parameter of a fluid within the inflow channel;
a second sensor arranged at a point along a length of the outflow channel outside of the cooling catheter, wherein the second sensor measures the parameter of the fluid within the outflow channel;
wherein at least one of the first sensor and the second sensor comprise a break-beam sensor that counts drops in a respective drip chamber; and
a processor to:
receive inflow data comprising the parameter of the fluid within the inflow channel measured by the first sensor;
receive outflow data comprising the parameter of the fluid within the outflow channel measured by the second sensor;
compare the inflow data to the outflow data to determine a parameter comparison value;
determine whether the parameter comparison value is outside of a tolerance range; and
cause, when the parameter comparison value is determined to be outside of the tolerance range, a signal to be output by at least one of a display and a speaker that notifies a user of a fluid flow restriction or a malfunction of the laser fiber cooling monitoring system.

2. The laser fiber cooling monitoring system of claim 1 , wherein the parameter is a fluid flow rate.

3. The laser fiber cooling monitoring system of claim 1 , wherein the parameter comparison value is a difference between an inflow fluid flow rate for the inflow channel and an outflow fluid flow rate for the outflow channel.

4. The laser fiber cooling monitoring system of claim 1 , wherein the processor determines, based on the parameter comparison value, an occurrence of a phase drift of a magnetic field during a laser ablation procedure.

5. The laser fiber cooling monitoring system of claim 1 , wherein the tolerance range is greater than 0.1 milliliters per minute.

6. The laser fiber cooling monitoring system of claim 1 , wherein the first sensor comprises a first break-beam sensor configured to count drops in an inflow drip chamber, and wherein the inflow drip chamber is arranged adjacent the cooling fluid source.

7. The laser fiber cooling monitoring system of claim 1 , further comprising a fluid pump configured to pump the that pumps fluid from the cooling fluid source into the inflow channel and through the fluid flow path.

8. The laser fiber cooling monitoring system of claim 1 , wherein the cooling fluid source comprises an intravenous (IV) bag of saline.

9. The laser fiber cooling monitoring system of claim 1 , wherein the first sensor comprises at least one of a first fluid flow sensor and a first temperature sensor, wherein the second sensor comprises at least one of a second fluid flow sensor and a second temperature sensor, wherein the inflow data comprises a first temperature and a first flow rate of the fluid within the inflow channel, wherein the outflow data comprises a second temperature and a second flow rate of the fluid within the outflow channel, and wherein the parameter comparison value is based on the first temperature, the second temperature, the first flow rate, and the second flow rate.

10. The laser fiber cooling monitoring system of claim 1 , wherein the processor is configured to control a laser energy source, and wherein the processor is configured to:
decrease, when the parameter comparison value is determined to be outside of the tolerance range, laser energy output from the laser energy source.

11. A method of laser ablation therapy, comprising:
providing a laser fiber cooling monitoring system, comprising:
a cooling catheter extending a length from a proximal end of the cooling catheter to a distal end of the cooling catheter, the cooling catheter comprising:
an inflow port disposed adjacent the proximal end;
an outflow port disposed adjacent the proximal end; and
a fluid flow path comprising a first fluid flow channel extending from the inflow port to a point inside the cooling catheter adjacent the distal end and a second fluid flow channel extending from the point inside the cooling catheter adjacent the distal end to the outflow port;

a cooling fluid source comprising a container that contains a cooling fluid;
an inflow channel arranged in fluid communication with the cooling fluid source, the inflow port, and the first fluid flow channel;
an outflow channel arranged in fluid communication with the outflow port and the second fluid flow channel;
a first sensor arranged at a point along a length of the inflow channel between the inflow port and the cooling fluid source, wherein the first sensor measures a parameter of a fluid within the inflow channel; and
a second sensor arranged at a point along a length of the outflow channel outside of the cooling catheter, wherein the second sensor measures the parameter of the fluid within the outflow channel;
wherein at least one of the first sensor and the second sensor comprise a break-beam sensor that counts drops in a respective drip chamber;

initiating a flow of the cooling fluid from the cooling fluid source through the fluid flow path, wherein a laser fiber is arranged in contact with a portion of the cooling fluid flowing along a length of the laser fiber in the fluid flow path;
receiving, from the first sensor, a first parameter value comprising the parameter of the fluid within the inflow channel prior to flowing along the length of the laser fiber in the fluid flow path;
receiving, from the second sensor, a second parameter value comprising the parameter of the fluid within the outflow channel after flowing along the length of the laser fiber in the fluid flow path;
comparing, by a processor, the first parameter value to the second parameter value to obtain a parameter comparison value;
determining, by the processor, whether parameter comparison value is outside a tolerance range; and
causing, by the processor when the parameter comparison value is determined to be outside of the tolerance range, a signal to be output by at least one of a display and a speaker that notifies a user of a fluid flow restriction or a malfunction of the laser fiber cooling monitoring system.

12. The method of claim 11 , wherein the parameter is a fluid flow rate.

13. The method of claim 11 , wherein the parameter comparison value is a difference between an inflow fluid flow rate for the inflow channel and an outflow fluid flow rate for the outflow channel.

14. The method of claim 11 , wherein the first sensor comprises a first break-beam sensor configured to count drops in an inflow drip chamber, and wherein the inflow drip chamber is arranged adjacent the cooling fluid source.

Assignees

• Medtronic Navigation Inc

Inventors

• Vaidyanathan Janardan
• Vincelette Rebecca
• Wilson Drew
• Drown Christine
• Capote Marco
• Santana Shawn

Classifications

• A61B2018/00577

  Ablation · CPC title

• A61B2018/00791

  Temperature · CPC title

• A61B2018/00642

  with feedback, i.e. closed loop control · CPC title

• A61B2018/00821

  measured by a thermocouple · CPC title

• A61B2018/00809

  measured thermochromatically · CPC title