Embossed film bioprocessing containers and integrity testing of bioprocessing containers
US-12050159-B2 · Jul 30, 2024 · US
Embossed film bioprocessing containers and integrity testing of bioprocessing containers
US12429397B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12429397-B2 |
| Application number | US-202318297085-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 7, 2023 |
| Priority date | Oct 3, 2017 |
| Publication date | Sep 30, 2025 |
| Grant date | Sep 30, 2025 |
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- Title
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Abstract
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A testing method that includes the steps of evacuating air from a container to a negative atmospheric pressure, the container being a collapsible, flexible container, and comprising at least two opposing flexible walls, wherein a surface of at least one of the walls internal to the container comprises a plurality of channels or recessed features on said at least one wall and monitoring a mass flow or a state of vacuum so as to determine the integrity of the container. The container can be of any size or conformation, with or without attached fittings.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for integrity testing a collapsible, flexible bioprocessing container using a system, the method comprising: a) providing a collapsible, flexible bioprocessing container, wherein the container comprises at least two opposing flexible walls, wherein the surface of the walls internal to the container comprise a plurality of channels on said walls; b) evacuating air from the container and a reference tank connected to the container to a negative atmospheric pressure; c) sealing the system, the system comprising the container, the tank, and a tester between the container and the tank; and d) monitoring vacuum decay in the system using the tester, so as to determine the integrity of the container. 2. The method of claim 1 , wherein the plurality of channels are embossed on said walls. 3. The method of claim 1 , wherein the surface of the walls are matte surfaces. 4. The method of claim 1 , wherein the collapsible, flexible bioprocessing container is pre-folded. 5. The method of claim 1 , wherein the collapsible, flexible bioprocessing container further comprises fittings, tubing, connectors, and a combination thereof. 6. The method of claim 1 , wherein the negative atmospheric pressure is between −1 psi to −14 psi. 7. A method of detecting a 2 micron or larger defect in a collapsible, flexible bioprocessing container, the method comprising: a) providing a collapsible, flexible bioprocessing container, the container comprising at least two opposing flexible walls, wherein the surface of the walls internal to the container comprise a plurality of channels on said walls; b) evacuating air from the container and a reference tank connected to the container to a negative atmospheric pressure; c) sealing the system, the system comprising the container, the tank, and a tester between the container and the tank; and d) monitoring vacuum decay of the system using the tester, wherein an increase in mass flow indicates the presence of a defect. 8. The method of claim 7 , wherein the plurality of channels are embossed on said walls. 9. The method of claim 8 , wherein the surface of the walls are matte surfaces. 10. The method of claim 7 , wherein the surface of the walls are matte surfaces. 11. The method of claim 7 , wherein the collapsible, flexible bioprocessing container is pre-folded. 12. The method of claim 7 , wherein the container further comprises fittings, tubing, connectors, and a combination thereof. 13. The method of claim 7 , wherein the negative atmospheric pressure is between −1 psi to −14 psi.
Assignees
Inventors
Classifications
Configuration of multiple channels and/or chambers in a single devices · CPC title
Flexible containers without fluid transport within · CPC title
Manifolds; Distribution pieces (fluid transfer means B01L3/563) · CPC title
disposable or single use · CPC title
flexible (flexible containers for laboratory use B01L3/505) · CPC title
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- What does patent US12429397B2 cover?
- A testing method that includes the steps of evacuating air from a container to a negative atmospheric pressure, the container being a collapsible, flexible container, and comprising at least two opposing flexible walls, wherein a surface of at least one of the walls internal to the container comprises a plurality of channels or recessed features on said at least one wall and monitoring a mass f…
- Who is the assignee on this patent?
- Emd Millipore Corp
- What technology area does this patent fall under?
- Primary CPC classification C12M23/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 5 related publications on this page (citations in our corpus or others sharing the same primary CPC).