Filtration system and method for synchronizing permeate and retentate flow

Patent metadata

Field	Value
Publication number	US-12427454-B2
Application number	US-202217852643-A
Country	US
Kind code	B2
Filing date	Jun 29, 2022
Priority date	Apr 16, 2021
Publication date	Sep 30, 2025
Grant date	Sep 30, 2025

Abstract

A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.

First claim

What is claimed is:

1. A method of operating a fluid filtration system, the method comprising:
transferring fluid from a fluid storage vessel, through a first pump, and to a filter housing;
filtering the fluid within the filter housing using a filter element disposed within the filter housing, and
removing a filtered portion of the fluid as permeate from the filter housing using a permeate pump, and
synchronizing a permeate flowrate through the permeate pump with a flowrate through the first pump such that a change in the first pump flow-rate automatically adjusts the permeate pump flow-rate.

2. The method of claim 1 , further comprising periodically performing a reverse flow operation to inject permeate back into the filter housing via the permeate pump to clean a filter element disposed in the filter housing.

3. The method of claim 2 , wherein the reverse flow operation comprises reverse flow at a constant flow rate that is the same as, greater than, or less than, a normal flowrate at which the permeate pump removes permeate from the filter housing under a normal operating condition.

4. The method of claim 1 , further comprising performing a pulse flow operation of the permeate flow via the permeate pump to clean a filter element disposed in the filter housing.

5. The method of claim 1 , wherein the permeate flowrate is controlled via a permeate valve disposed in a permeate discharge line.

6. The method of claim 1 , further comprising periodically increasing permeate flowrate through the permeate pump to clean a filter element disposed in the filter housing.

7. The method of claim 1 , wherein the transferring and removing steps are performed at the same time.

8. The method of claim 1 , further comprising periodically turning the permeate pump off to reduce or stop flow through the permeate pump.

9. The method of claim 1 , further comprising switching the permeate pump to a filter cleaning mode when permeate pressure in a permeate discharge line passes a predetermined value.

10. The method of claim 9 , wherein the permeate pump remains in the filter cleaning mode for a predetermined time, or until the permeate pressure exceeds the predetermined value.

11. A fluid filtration system, comprising:
a fluid storage vessel;
a filter housing including a filter element therein;
a first pump coupled between the fluid storage vessel and the filter housing, the first pump configured for transferring fluid from the fluid storage vessel to the filter housing;
a permeate pump coupled to the filter housing for removing a permeate from the filter housing, wherein the permeate comprises a portion of the fluid that is filtered by the filter element during operation of the system; and
a controller coupled to the first pump and the permeate pump, the controller including a processor programmed to execute instructions to control the permeate pump and the first pump to synchronize a permeate flowrate through the permeate pump with a flow rate through the first pump such that a change in the first pump flow-rate automatically adjusts the permeate pump flow-rate.

12. The system of claim 11 , wherein the processor is programmed to execute instructions to control the permeate pump to periodically perform a reverse flow operation to inject permeate back into the filter housing to clean the filter element.

13. The system of claim 12 , wherein the processor is programmed to execute instructions to control the permeate pump to inject permeate back into the filter housing at a constant flow rate that is the same as, greater than, or less than, a normal flowrate at which the permeate pump removes permeate from the filter housing under a normal operating condition.

14. The system of claim 11 , wherein the processor is programmed to execute instructions to control the permeate pump to perform a pulse flow operation of the permeate flow to clean the filter element.

15. The system of claim 11 , further comprising a valve disposed in a permeate discharge line coupled to the filter housing, wherein the controller is coupled to the valve, and wherein the processor is programmed to execute instructions to control the valve to control the permeate flowrate in the permeate discharge line.

16. The system of claim 11 , wherein the processor is programmed to execute instructions to control the permeate pump to periodically increase the permeate flowrate to clean the filter element.

17. The system of claim 11 , wherein the processor is programmed to execute instructions to control the first pump and the permeate pump so that the fluid is transferred from the fluid storage vessel to the filter housing and the permeate is removed from the filter housing at the same time.

18. The system of claim 11 , wherein the processor is programmed to execute instructions to periodically turn the permeate pump off to reduce or stop flow through the permeate pump.

19. The system of claim 11 , wherein the processor is programmed to execute instructions to switch the permeate pump to a filter cleaning mode when permeate pressure in a permeate discharge line passes a predetermined value.

20. The system of claim 19 , wherein the processor is programmed to execute instructions to maintain the permeate pump in the filter cleaning mode for a predetermined time, or until the permeate pressure exceeds the predetermined value.

Assignees

• Repligen Corp

Inventors

• Pavlik Rudolf
• Kuriyel Ralf

Classifications

• B01D29/902

  containing fixed liquid displacement elements or cores · CPC title

• B01D2321/12

  Use of permeate · CPC title

• B01D2321/04

  Backflushing · CPC title

• C12M29/16

  Hollow fibers (hollow fiber modules in general B01D63/02) · CPC title

• C12M41/44

  of volume or liquid level · CPC title