Bioelectronic lens (e-lens) system for electrical stimulation and neuroprotection of the retina

Patent metadata

Field	Value
Publication number	US-12427303-B2
Application number	US-202217685186-A
Country	US
Kind code	B2
Filing date	Mar 2, 2022
Priority date	Mar 2, 2021
Publication date	Sep 30, 2025
Grant date	Sep 30, 2025

Abstract

Bioelectronic lens (E-lens) systems for inducing neuroprotective changes in neurons, in particular the retina. A system may include a stimulating electrode configured to be placed on an eye or skin around the eye. The system may further include a return electrode configured such that voltage distribution is focalized to the eye and induced electric fields to an area of interest on the eye or on the skin around the eye are maximized. The electric fields provide neuroprotection and reinnervation.

First claim

What is claimed is:

1. A system for providing electrical stimulation, comprising:
a circuit configured to generate and wirelessly transmit a charge balanced and load independent stimulation waveform;
a battery-less passive receiver coil configured to wirelessly receive the stimulation waveform;
a first stimulating electrode electrically connected to the battery-less passive receiver coil and configured to be placed on a first portion of an eye of a patient and to receive the stimulation waveform;
a return electrode electrically connected to the battery-less passive receiver coil and configured to be placed on a second portion of the eye such that current or voltage distribution is focalized to the eye and induced electric fields to an area of interest on or into the eye are maximized, wherein the electric fields provide neuroprotection and reinnervation;
a ground electrically connected to the first stimulating electrode or the return electrode, the ground configured to be placed on a head of the patient, on skin adjacent to the eye or a non-stimulated eye or on a temporal area of the eye or the non-stimulated eye to induce the electric fields; and
a passive electrode not electrically connected to the battery-less passive receiver coil and configured to be placed on the head of the patient to induce the electric fields in a brain and/or an optic nerve of the patient.

2. The system of claim 1 , wherein the stimulation waveform is of long pulse durations to stimulate the eye and induce the electric fields to create epigenetic changes.

3. The system of claim 1 , wherein responses of retinal neurons to transcorneal electrical stimulation of various stimulus parameters are analyzed.

4. The system of claim 1 , wherein the area of interest on the eye includes a retina and an optic nerve, a ciliary body, a lacrimal gland, or a cornea including corneal nerves.

5. The system of claim 1 , further comprising:
a second stimulating electrode electrically connected to the battery-less passive receiver coil,
wherein the circuit is further configured to independently control stimulation of the first stimulating electrode and the second stimulating electrode from a transmitter end.

6. The system of claim 1 , further comprising a power source configured to supply power to the system.

7. The system of claim 6 , wherein the power source is a battery configured to be placed on the eye, a temporal site of the eye, eyeglasses, a head of the patient, or behind an ear of the patient.

8. A system for providing electrical stimulation, comprising:
a circuit configured to generate or receive a stimulation waveform;
a stimulating electrode electrically connected to the circuit and configured to be placed on a first portion of an eye of a patient;
a return electrode electrically connected to the circuit and configured to be placed on a second portion of the eye, the second portion being posterior to the first portion, such that voltage distribution is focalized to a central nervous system (CNS) and induced electric fields to an area of interest are maximized; and
a passive electrode not electrically connected to the circuit and configured to be placed on a forehead or a back of a head of the patient to induce the electric fields in layers of the CNS,
wherein the electric fields provide neuroprotection and reinnervation.

9. The system of claim 8 , wherein a symmetric biphasic charge-balanced waveform of long pulse durations is used to stimulate the eye and induce the electric fields to create epigenetic changes in the CNS.

10. The system of claim 8 , wherein the area of interest includes later geniculate, visual cortex, superior colliculus, motor cortex, frontal cortex, sensory cortex, other visual cortical areas, hippocampus, other subcortical regions, brainstem, or areas associated with the brainstem.

11. A system for providing electrical stimulation, comprising:
a circuit configured to generate and wirelessly transmit a symmetric biphasic charge-balanced waveform;
a battery-less passive receiver coil configured to wirelessly receive the symmetric biphasic charge-balanced waveform;
a stimulating electrode electrically connected to the battery-less passive receiver coil and configured to be placed on a first portion of an eye of a patient;
a return electrode electrically connected to the battery-less passive receiver coil and configured to be placed on a second portion of the eye such that a current density distribution is maximized along an optic nerve and in a superior colliculus; and
a passive electrode not electrically connected to the battery-less passive receiver coil and configured to be placed on a head of the patient to induce the electric fields in a brain and/or the optic nerve of the patient.

12. The system of claim 1 , wherein the first portion is adjacent to the second portion.

13. The system of claim 1 , further comprising one or more resonating capacitors electrically connected to the battery-less passive receiver coil.

14. The system of claim 8 , wherein the circuit includes a battery-less passive receiver coil electrically connected to the stimulating electrode and configured to wirelessly receive a symmetric biphasic charge-balanced waveform.

15. The system of claim 14 , further comprising one or more resonating capacitors electrically connected to the battery-less passive receiver coil.

16. The system of claim 11 , further comprising a contact lens configured to be placed on the eye and to house the battery-less passive receiver coil.

17. The system of claim 16 , further comprising one or more resonating capacitors electrically connected to the battery-less passive receiver coil.

18. The system of claim 1 , wherein the passive electrode is not electrically connected to the stimulating electrode and is not electrically connected to the return electrode.

Assignees

• Univ Southern California

Inventors

• Humayun Mark S
• Lazzi Gianluca
• Salhia Bodour
• Machnoor Manjunath
• Paknahad Javad
• Gonzalez-Calle Alejandra
• Tew Ben Yi

Classifications

• A61N1/0492

  Patch electrodes (A61N1/0412, A61N1/0428 take precedence) · CPC title

• A61N1/40

  Applying electric fields by inductive or capacitive coupling (microwave apparatus A61N5/00); {Applying radio-frequency signals} · CPC title

• A61N1/0456

  Specially adapted for transcutaneous electrical nerve stimulation [TENS] · CPC title

• A61N1/14

  Leading-off electric charges, e.g. by earthing {(carrying-off electrostatic charges, in general H05F3/00)} · CPC title

• A61N1/0543

  Retinal electrodes · CPC title