Combined extracorporeal and drug delivery system and method

Patent metadata

Field	Value
Publication number	US-12427235-B2
Application number	US-202017116561-A
Country	US
Kind code	B2
Filing date	Dec 9, 2020
Priority date	Dec 10, 2019
Publication date	Sep 30, 2025
Grant date	Sep 30, 2025

Abstract

An extracorporeal and drug delivery system includes (i) a renal failure therapy machine operable with a blood filter in fluid communication with an arterial line and a venous line, the machine including (a) an effluent pump for pumping effluent from the blood filter at an effluent flowrate, and at least one of (b) a dialysis fluid pump for pumping dialysis fluid to the blood filter at a dialysis fluid flowrate, (c) a predilution pump for pumping replacement fluid into the arterial line at a predilution flowrate, or (d) a postdilution pump for pumping replacement fluid into the venous line at a postdilution flowrate; (ii) an infusion pump operable to deliver an intravenous (“IV”) drug to the patient at an IV drug flowrate; and (iii) a coordinating logic implementor configured to adjust the IV drug flowrate based on an amount of the IV drug removed via the effluent flowrate.

First claim

The invention is claimed as follows:

1. An extracorporeal and drug delivery system comprising:
a renal failure therapy machine operable with a blood filter in fluid communication with an arterial line for removing blood from a patient to the blood filter and a venous line for returning blood from the blood filter to the patient, the renal failure therapy machine including
an effluent pump positioned and arranged to pump effluent from the blood filter at an effluent flowrate, and
at least one of
a dialysis fluid pump positioned and arranged to pump dialysis fluid to the blood filter at a dialysis fluid flowrate,
a predilution pump positioned and arranged to pump replacement fluid into the arterial line at a predilution flowrate, or
a postdilution pump positioned and arranged to pump replacement fluid into the venous line at a postdilution flowrate;

an infusion pump operable to deliver an intravenous (“IV”) drug to the patient at an IV drug flowrate; and
a coordinating logic implementor configured to:
determine the effluent flowrate using a fluid balance equation that relates the effluent flowrate to a sum between an ultrafiltration removal rate and a total patient fluid input rate that includes the at least one of the dialysis fluid flowrate, the predilution flowrate, or the postdilution flowrate,
estimate a blood volume using a patient weight,
determine an adjustment for the IV drug flowrate based on the estimated blood volume of the patient and an amount of the IV drug removed via the determined effluent flowrate,
determine an adjustment percentage by dividing the adjustment for the IV drug flowrate by the determined effluent flowrate,
when the adjustment percentage is greater than a threshold, iteratively determine the effluent flowrate and a resulting adjustment for the IV drug flowrate until the adjustment percentage is less than the threshold, and
when the adjustment percentage is less than the threshold, implement at least the adjustment for the IV drug flowrate at the infusion pump.

2. The extracorporeal and drug delivery system of claim 1 , wherein the renal failure therapy machine is a continuous renal replacement machine, and which includes the effluent pump and at least two of the dialysis fluid pump, the predilution pump, or the postdilution pump.

3. The extracorporeal and drug delivery system of claim 1 , wherein the renal failure therapy machine is a hemodialysis machine, and which includes the effluent pump and the dialysis fluid pump.

4. The extracorporeal and drug delivery system of claim 1 , wherein the coordinating logic implementor is provided separately from the renal failure therapy machine and the infusion pump, and wherein the coordinating logic implementor is in wired or wireless communication with at least the renal failure therapy machine.

5. The extracorporeal and drug delivery system of claim 4 , which is configured such that the total patient fluid input rate is communicated to or determined by the coordinating logic implementor for the coordinating logic implementor to determine the adjustment for the IV drug flowrate.

6. The extracorporeal and drug delivery system of claim 1 , which is configured to display the adjustment for the IV drug flowrate at one or more of the renal failure therapy machine, the infusion pump, or the coordinating logic implementor before implementing the adjustment for the IV drug flowrate.

7. The extracorporeal and drug delivery system of claim 1 , wherein the coordinating logic implementor is integrated into the renal failure therapy machine.

8. The extracorporeal and drug delivery system of claim 1 , wherein the infusion pump is a first infusion pump, the IV drug is a first IV drug, the IV drug flowrate is a first IV drug flowrate, which includes a second infusion pump operable to deliver a second IV drug to the patient at a second IV drug flowrate, and wherein the coordinating logic implementor is configured to determine an adjustment for the second IV drug flowrate based on an amount of the second IV drug removed via the effluent flowrate.

9. The extracorporeal and drug delivery system of claim 1 , which is configured such that the determination of the effluent flowrate additionally takes into account the adjustment for the IV drug flowrate.

10. The extracorporeal and drug delivery system of claim 1 , which is configured such that the determination of the effluent flowrate additionally takes into account a prescribed patient fluid loss rate.

11. The extracorporeal and drug delivery system of claim 1 , wherein the amount of the IV drug removed via the effluent flowrate includes a percentage of the IV drug in the effluent flowrate.

12. The extracorporeal and drug delivery system of claim 1 , wherein the threshold is 0.5%.

13. The extracorporeal and drug delivery system of claim 1 , wherein the coordinating logic implementor is further configured to take into account blood filter patency or clotting in determining the adjustment for the IV drug flowrate.

14. The extracorporeal and drug delivery system of claim 13 , which is configured such that the adjustment for the IV drug flowrate causes the IV drug flowrate to meet a prescribed IV drug flowrate when the amount of the IV drug is removed via the effluent flowrate.

15. The extracorporeal and drug delivery system of claim 1 , wherein the renal failure therapy machine is a first renal failure therapy machine, the infusion pump is a first infusion pump, which includes a second renal failure therapy machine associated with a second infusion pump, and wherein the coordinating logic implementor is configured to determine an adjustment for a second IV drug flowrate of the second infusion pump.

16. An extracorporeal and drug delivery system comprising:
a renal failure therapy machine operable with a blood filter in fluid communication with an arterial line for removing blood from a patient to the blood filter and a venous line for returning blood from the blood filter to the patient, the renal failure therapy machine including
an effluent pump positioned and arranged to pump effluent from the blood filter at an effluent flowrate, and
at least one of
a dialysis fluid pump positioned and arranged to pump dialysis fluid to the blood filter at a dialysis fluid flowrate,
a predilution pump positioned and arranged to pump replacement fluid into the arterial line at a predilution flowrate, or
a postdilution pump positioned and arranged to pump replacement fluid into the venous line at a postdilution flowrate;

an infusion pump operable to deliver an intravenous (“IV”) drug to the patient; and
a coordinating logic implementor configured to:
determine the effluent flowrate using a fluid balance equation that relates the effluent flowrate to a sum between an ultrafiltration removal rate and a total patient fluid input rate that includes the at least one of the dialysis fluid flowrate, the predilution flowrate, or the postdilution flowrate,
estimate a blood volume using a patient weight,
determine an adjustment to a concentration of the IV drug based on the estimated blood volume of the patient and an amount of the IV drug removed via the determined effluent flowrate,
determine an adjustment value by comparing the adjustment to the concentration of the IV drug to the determined effluent flowrate,
when the adjustment value is greater than a threshold, iteratively determine the effluent flowrate and a resulting adjustment to the concentration of the IV drug until the adjustment value is less than the threshold, and
when the adjustment value is less than the threshold, implement at

Assignees

• Baxter Int
• Baxter Healthcare Sa

Inventors

• Zacharia John Ramez
• Wittner Bernd
• Bivans Matthew

Classifications

• A61M2205/3553

  remote, e.g. between patient's home and doctor's office · CPC title

• A61M5/16877

  Adjusting flow; Devices for setting a flow rate · CPC title

• A61M1/38

  Removing constituents from donor blood and {storing or} returning remainder to body {, e.g. for transfusion} · CPC title

• A61M1/3621

  Extra-corporeal blood circuits (single-needle circuits A61M1/30) · CPC title

• A61M1/3607

  Regulation parameters · CPC title