Pharmaceutical composition for treating or preventing aging or age-related diseases

Patent metadata

Field	Value
Publication number	US-12427143-B2
Application number	US-202117633576-A
Country	US
Kind code	B2
Filing date	Jul 23, 2021
Priority date	Feb 18, 2021
Publication date	Sep 30, 2025
Grant date	Sep 30, 2025

Abstract

HTS screening was performed regarding cell proliferation, one of symptoms of senescence. As a result, KB1541, which was the most effective on cell proliferation, was earned. The present invention described how the compound regulates cell proliferation and senescence. The present invention uncovered what proteins interacted with the compound using streptavidin-magnetic beads after treating with biotin-connected KB1541. Consequently, it was identified that mitochondrial proteins interacted with the compound. In ATP assay, electron microscope and IP assay, the inventors identified that the compound regulated mitochondrial proteins and thereby increased ATP production as well as recovered senescence.

First claim

What is claimed is:

1. A method of treating or preventing cell aging related diseases, comprising:
administering a pharmaceutical composition comprising a compound of [Chemical Formula 1] as an active ingredient to a subject:

wherein the pharmaceutical composition upregulates 14-3-3 zeta/delta protein in cells, subsequently activates ATP synthase, and thereby enhances adenosine triphosphate (ATP) production and alleviating cellular senescence.

2. The method of the claim 1 , wherein the cell aging is induced by malfunction of mitochondria.

3. The method of the claim 1 , wherein the composition increases or forms cristae of mitochondria.

4. The method of the claim 1 , wherein the composition activates autophagy in a cell.

5. The method of the claim 1 , wherein the composition reduces reactive oxygen species(ROS) in a cell.

6. The method of the claim 1 , wherein the cell aging related diseases are selected from a group consisting of neurodegenerative diseases or disorders, cardiovascular diseases or disorders, metabolic diseases or disorders, pulmonary diseases or disorders, inflammatory or autoimmune diseases or disorders, transplant related diseases and disorders, ophthalmic diseases or disorders, proliferative diseases or disorders, chemotherapy or radiotherapy side effects, age-related diseases or disorders, fibrotic diseases or disorders, dermatological diseases or disorders, aged stem cell related diseases or disorders.

7. A method of treating or preventing cell aging related diseases, comprising:
administering a functional food comprising a compound of [Chemical Formula 1] as an active ingredient to a subject:

wherein the functional food composition upregulates 14-3-3 zeta/delta protein in cells, subsequently activates ATP synthase, and thereby enhances adenosine triphosphate (ATP) production and alleviating cellular senescence.

8. A method of treating or preventing cell aging related diseases, comprising:
administering a cosmetic composition comprising a compound of [Chemical Formula 1] as an active ingredient to a subject:

wherein the cosmetic composition upregulates 14-3-3 zeta/delta protein in cells, subsequently activates ATP synthase, and thereby enhances adenosine triphosphate (ATP) production and alleviating cellular senescence.

Assignees

• Inu Res & Business Foundation
• Univ Korea Res & Business Foundation Sejong Campus

Inventors

• Park Joon Tae
• Lee Yun Haeng
• Byun Young Joo
• Choi Do Young

Classifications

• A61Q19/08

  Anti-ageing preparations · CPC title

• A61K8/49

  containing heterocyclic compounds · CPC title

• A23L33/10 Primary

  using additives (addition of substantially indigestible substances A23L33/21) · CPC title

• A61K2800/522

  Antioxidants; Radical scavengers · CPC title

• A61K2800/78

  Enzyme modulators, e.g. Enzyme agonists · CPC title