Bionic inter vertebral disc with mechanical anisotropy

Patent metadata

Field	Value
Publication number	US-12427032-B2
Application number	US-202318451189-A
Country	US
Kind code	B2
Filing date	Aug 17, 2023
Priority date	Jan 3, 2023
Publication date	Sep 30, 2025
Grant date	Sep 30, 2025

Abstract

A bionic intervertebral disc with mechanical anisotropy includes an upper end plate, a core and a lower end plate. The core includes outer fibrous rings, a middle transition zone and an inner nucleus pulposus. The fibrous rings comprise collagen fiber sheets and collagen fibers, each of the collagen fibers is attached to a surface of a corresponding one of the collagen fiber sheets and arranged at an inclination angle, ones of the collagen fibers which are on every two adjacent layers of the collagen fiber sheets are arranged crosswise with each other. A honeycomb meshing size of a portion, which is located at a fibrous-ring transition zone, of the honeycomb structure is smaller and more compact, and a honeycomb meshing size of a portion, which is located at a nucleus pulposus transition zone, of the honeycomb structure is larger and sparser.

First claim

What is claimed is:

1. A bionic intervertebral disc with mechanical anisotropy, comprising an upper end plate, a core and a lower end plate, wherein an upper end of the core is fixed on a lower surface of the upper end plate, and a lower end of the core is fixed on an upper surface of the lower end plate; an upper surface of the upper end plate is provided with upper spikes, and a lower surface of the lower end plate is provided with lower spikes;
the core comprises outer fibrous rings, a middle transition zone and an inner nucleus pulposus, the fibrous rings comprise collagen fiber sheets and collagen fibers, each of the collagen fibers is attached to a surface of a corresponding one of the collagen fiber sheets and arranged at an inclination angle, ones of the collagen fibers which are on every two adjacent layers of the collagen fiber sheets are arranged crosswise with each other, upper ends of the collagen fibers are tightly connected with the upper end plate, and lower ends of the collagen fibers are tightly connected with the lower end plate;
the collagen fibers are made of polymer materials with different elastic moduli, the elastic moduli of the collagen fibers from an anterior part of the bionic intervertebral disc to a posterior part of the bionic intervertebral disc are gradiently changed and gradually decreased, and the elastic moduli of ones, which are on a right side and a left side of an sagittal plane of the bionic intervertebral disc, of the collagen fibers are symmetrically distributed; and
the transition zone comprises a matrix layer and elastic fibers, the elastic fibers are attached to a surface of the matrix layer, and the elastic fibers comprise coarse elastic fibers and fine elastic fibers;
wherein the fibrous rings comprise odd-numbered-layer fibrous rings and even-numbered-layer fibrous rings; a number of the collagen fiber sheets is 4 to 25, and the collagen fiber sheets comprise collagen fiber sheets of the odd-numbered-layer fibrous rings and collagen fiber sheets of the even-numbered-layer fibrous rings;
wherein the odd-numbered-layer fibrous rings comprise the collagen fiber sheets of the odd-numbered-layer fibrous rings and collagen fibers of the odd-numbered-layer fibrous rings, each of ones, which are on the right side of the sagittal plane, of the collagen fibers of odd-numbered-layer fibrous rings is inclined counterclockwise from a bottom end to a top end thereof, and each of ones, which are on the left side of the sagittal plane, of the collagen fiber of odd-numbered-layer fibrous rings is inclined clockwise from a bottom end to a top end thereof; and
the even-numbered-layer fibrous rings comprise the collagen fiber sheets of the even-numbered-layer fibrous rings and collagen fibers of the even-numbered-layer fibrous rings, each of ones, which are on the right side of the sagittal plane, of the collagen fibers of the even-numbered-layer fibrous rings is inclined clockwise from a bottom end to a top end thereof, and each of ones, which are on the left side of the sagittal plane, of the collagen fibers of even-numbered-layer fibrous rings is inclined counterclockwise from a lower end to a top end thereof.

2. The bionic intervertebral disc with mechanical anisotropy according to claim 1 , wherein the elastic fibers and the matrix layer of the transition zone form a honeycomb structure, and a honeycomb meshing size of a portion, which is located at a fibrous-ring transition zone, of the honeycomb structure is smaller and more compact, and a honeycomb meshing size of a portion, which is located at a nucleus pulposus transition zone, of the honeycomb structure is larger and sparser; and ones of the elastic fibers which are located in the anterior part have larger diameters than ones of the elastic fibers which are located in the posterior part, and the fine elastic fibers are interspersed among the coarse elastic fibers.

3. The bionic intervertebral disc with mechanical anisotropy according to claim 1 , wherein each of the inclination angles is an included angle between a corresponding one of the collagen fibers and a horizontal plane, anterior inclination angles of the inclination angles which are at the anterior part are 20 degrees, posterior inclination angles of the inclination angles which are at the posterior part are 70 degrees, the inclination angles are gradually increased in turn from the anterior part to the posterior part, and ones of the inclination angles which are on the right side and the left side of the sagittal plane of the bionic intervertebral disc are symmetrically distributed.

4. The bionic intervertebral disc with mechanical anisotropy according to claim 1 , wherein
the upper end plate, the lower end plate, the upper spikes and the lower spikes are made of a polyether ether ketone polymer;
the nucleus pulposus is made of an agarose hydrogel analogue;
the collagen fiber sheets are made of a polyurethane polymer material, and the collagen fibers are made of the polyurethane polymer material;
the matrix layer is made of the polyurethane polymer material; and
the elastic fibers are made of the polyurethane polymer material.

Assignees

• Univ Jilin

Inventors

• Qian Zhihui
• Fan Weiguo
• Ren Lei
• Wang Kunyang
• Wang Shengli
• Song Guangsheng
• Xie Xia
• Ren Luquan

Classifications

• A61F2/441

  made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel · CPC title

• A61F2250/0014

  having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis · CPC title

• A61F2002/444

  for replacing the nucleus pulposus · CPC title

• A61F2/442 Primary

  Intervertebral or spinal discs, e.g. resilient (non-disc-shaped intervertebral inflatable pockets A61F2/441; non-disc-shaped intervertebral fusion implants A61F2/4455) · CPC title

• A61F2002/4495

  having a fabric structure, e.g. made from wires or fibres · CPC title