System and method for comparing SPECT and PET image data in theranostics

Patent metadata

Field	Value
Publication number	US-12423808-B2
Application number	US-202218060688-A
Country	US
Kind code	B2
Filing date	Dec 1, 2022
Priority date	Dec 1, 2022
Publication date	Sep 23, 2025
Grant date	Sep 23, 2025

Abstract

A computing system includes computer readable medium and a processor. The computer readable medium includes a computer readable medium including a positron emission tomography (PET)-to-single photon emission tomography (SPECT) module with instructions for generating simulated SPECT image data based on first PET image data. The PET image data is acquired prior to a treatment course of a treatment regimen with a SPECT-based treatment/imaging radiopharmaceutical. The processor is configured to obtain the first PET image data, system parameters of a SPECT-CT imaging system utilized to generate corresponding SPECT image data for the treatment regimen and scan parameters utilized by the SPECT-CT imaging system to acquire the corresponding SPECT image data. The processor is further configured to execute the instructions to generate the simulated SPECT image data based on the PET image data and the system parameters and the scan parameters.

First claim

What is claimed is:

1. A computing system, comprising:
computer readable medium including a positron emission tomography (PET)-to-single photon emission tomography (SPECT) module with instructions for generating simulated SPECT image data based on first PET image data, wherein the first PET image data is acquired prior to a treatment course of a treatment regimen with a SPECT-based treatment/imaging radiopharmaceutical; and
a processor configured to obtain the first PET image data, system parameters of a SPECT-CT imaging system utilized to generate corresponding SPECT image data for the treatment regimen and scan parameters utilized by the SPECT-CT imaging system to acquire the corresponding SPECT image data, and execute the instructions to forward project the PET image data into SPECT projections based on the system parameters and the scan parameters and reconstruct the SPECT projections to generate the simulated SPECT data.

2. The computing system of claim 1 , wherein the processor is further configured to:
normalize the SPECT projections to generate normalized SPECT projections;
add noise to the normalized SPECT projections to generate normalized SPECT projections with noise; and
reconstruct the normalized SPECT projections with noise to generate the simulated SPECT image data.

3. The computing system of claim 2 , wherein the processor is further configured to:
extract a second SPECT FOV from the PET image data;
forward project the PET image into second SPECT projections;
normalize the second SPECT projections to generate second normalized SPECT projections;
add noise to the second normalized SPECT projections to generate second normalized SPECT projections with noise;
reconstruct the second normalized SPECT projections with noise to generate second simulated SPECT image data; and
combine the simulated SPECT image data and the second simulated SPECT image data to create a single set of simulated SPECT image data.

4. The computing system of claim 1 , wherein the processor is further configured to:
obtain first SPECT image data acquired after the treatment course of the treatment regimen; and
compare the simulated SPECT image data and the first SPECT image data.

5. The computing system of claim 4 , wherein the processor is further configured to:
obtain second SPECT image data acquired after a second treatment course of the treatment regimen; and
compare at least one of the simulated SPECT image data or the first SPECT image data with the second SPECT image data.

6. The computing system of claim 1 , wherein the processor is further configured to:
obtain second PET image data acquired after the treatment regimen;
generate second simulated SPECT image data based on the second PET image data and the system and scan parameters; and
compare the simulated SPECT image data and the second simulated SPECT image data.

7. The computing system of claim 1 , wherein the processor is further configured to:
obtain second PET image data acquired after the treatment regimen; and
compare the PET image data and the second PET image data.

8. The computing system of claim 1 , wherein the processor is further configured to:
obtain second PET image data acquired after the treatment regimen;
generate second simulated SPECT image data based on the second PET image data and the system and scan parameters; and
compare the simulated SPECT image data and the second simulated SPECT image data.

9. The computing system of claim 1 , wherein the processor is further configured to:
obtain a dosimetry value of primary tissue of interest or healthy tissue in SPECT image data acquired after the treatment course of the treatment regimen;
identify the primary tissue of interest and secondary tissue of interest in the PET image data;
determine a value of a secondary-to-primary tissue of interest characteristic;
obtain a total radiation dose; and
estimate a radiation dose of the secondary tissue of interest based on the dosimetry value, the value of the secondary-to-primary tissue of interest characteristic and the total radiation dose.

10. The computing system of claim 9 , wherein the processor further estimates the radiation dose based on a factor indicative of an imaging relationship between SPECT and PET imaging.

11. A computer-implemented method, comprising:
obtaining first PET image data that was acquired prior to a treatment course of a treatment regimen with a SPECT-based treatment/imaging radiopharmaceutical;
obtaining system parameters of a SPECT-CT imaging system utilized to acquire SPECT image data for the treatment regimen and scan parameters utilized by the SPECT-CT imaging system to acquire the SPECT image data; and
generating a simulated SPECT image data by forward projecting the PET image data into SPECT projections based on the system parameters and the scan parameters and reconstructing the SPECT projections.

12. The computer-implemented method of claim 11 , further comprising:
normalizing the SPECT projections to generate normalized SPECT projections;
adding noise to the normalized SPECT projections to generate normalized SPECT projections with noise; and
reconstructing the normalized SPECT projections with noise to generate the simulated SPECT image data.

13. The computer-implemented method of claim 11 , further comprising:
extracting a second SPECT FOV from the PET image data;
forward projecting the PET image into second SPECT projections;
normalizing the second SPECT projections to generate second normalized SPECT projections;
adding noise to the second normalized SPECT projections to generate second normalized SPECT projections with noise;
reconstructing the second normalized SPECT projections with noise to generate second simulated SPECT image data; and
combining the simulated SPECT image data and the second simulated SPECT image data to create a single set of SPECT image data.

14. The computer-implemented method of claim 11 , further comprising:
obtaining second PET image data acquired after the treatment regimen;
generating second simulated SPECT image data based on the second PET image data and the system and scan parameters; and
comparing the simulated SPECT image data and the second simulated SPECT image.

15. The computer-implemented method of claim 11 , further comprising:
obtaining a dosimetry value of primary tissue of interest or healthy tissue in SPECT image data acquired after the treatment course of the treatment regimen;
identifying the primary tissue of interest and secondary tissue of interest in the PET image data;
determining a value of a secondary-to-primary tissue of interest characteristic;
obtaining a total radiation dose; and
estimating a radiation dose of the secondary tissue of interest based on the dosimetry value, the value of the secondary-to-primary tissue of interest characteristic and the total radiation dose.

16. A computer readable storage medium encoded with computer executable instructions which when executed by a processor cause the processor to:
obtain first PET image data that was acquired prior to a treatment course of a treatment regimen with a SPECT-based treatment/imaging radiopharmaceutical;
obtain system parameters of a SPECT-CT imaging system to be utilized to acquire SPECT image data and scan parameters utilized by the SPECT-CT imaging system to acquire the SPECT image data; and
generate a-simulated SPECT image data by forward projecting the PET image data into SPECT projections based on; the system parameters and the scan parameters and reconstructing the SPECT projections.

Assignees

• Ge Prec Healthcare Llc

Inventors

• Sachs Jonathan
• Carmi Raz

Classifications

• G06T12/10

  Image preprocessing, e.g. calibration, positioning of sources or scatter correction · CPC title

• G01T1/02 Primary

  Dosimeters (G01T1/15 takes precedence) · CPC title

• G06T2207/10108

  Single photon emission computed tomography [SPECT] · CPC title

• G06T2207/10104

  Positron emission tomography [PET] · CPC title

• G06T2207/20221

  Image fusion; Image merging · CPC title