Microchannel chip

Patent metadata

Field	Value
Publication number	US-12420281-B2
Application number	US-202017641220-A
Country	US
Kind code	B2
Filing date	Sep 28, 2020
Priority date	Oct 2, 2019
Publication date	Sep 23, 2025
Grant date	Sep 23, 2025

Abstract

A microchannel chip ( 1 ) includes: a first channel ( 201 ); a reagent holder ( 230 ); a gas inlet ( 210 ) communicating with the first channel; a lid ( 50 ) closing the gas inlet; and a second channel ( 202 ) provided downstream of the first channel. A specimen holder ( 240 ) is provided downstream of the reagent holder ( 230 ). When the lid ( 50 ) closes the gas inlet ( 210 ), gas is supplied to the first channel ( 201 ) and pushes out the reagent downstream from the reagent holder ( 230 ). Thus, the pushed-out reagent merges with a specimen in the second channel ( 202 ).

First claim

The invention claimed is:

1. A microchannel chip for mixing a first liquid and a second liquid to supply a mixed liquid, the microchannel chip comprising:
a first base plate;
a first channel having an inlet and an outlet, the first channel being formed in a first surface of the first base plate;
a second base plate laminated on and bonded to the first base plate so as to face the first surface;
a first liquid holder formed in the first surface of the first base plate with the first channel and having a larger cross-sectional area than the first channel when orthogonally intersecting with a liquid feeding direction, the first liquid holder to store the first liquid and being capable of communicating with the first channel;
a gas inlet communicating with the inlet of the first channel and being opened to an outside of the microchannel chip, the gas inlet being provided in the first base plate so as to open to a second surface on an opposite side of the first surface;
a lid closing the gas inlet, the lid to be attached facing to the second surface;
a second channel having an inlet and an outlet; and
a second liquid holder capable of communicating with the first liquid holder, the second liquid holder to hold the second liquid, wherein
the lid includes a third channel capable of being connected to the first channel,
the outlet of the second channel is opened to the outside of the microchannel chip, and
when the lid is closed, the outlet of the first channel is connected to the inlet of the second channel provided in the first base plate via the third channel, gas is supplied to the inlet of the first channel and pushes out the first liquid from the first liquid holder toward the outlet of the first channel, and the pushed-out first liquid merges with the second liquid from the second liquid holder in the second channel.

2. The microchannel chip according to claim 1 , wherein
the second liquid holder is provided on the second channel, and an opening part to introduce the second liquid is formed in the second surface.

3. The microchannel chip according to claim 1 , wherein
the second liquid holder is provided so as to protrude from the second surface.

4. The microchannel chip according to claim 1 , wherein
the second liquid holder is provided on the third channel, and an opening part to introduce the second liquid is formed in the lid so as to open to a surface facing the second surface.

5. The microchannel chip according to claim 4 , wherein
the second liquid holder is formed in an outlet end of the third channel, and is connected to the inlet of the second channel when the lid is closed.

6. A microchannel chip for mixing a first liquid and a second liquid to supply a mixed liquid, the microchannel chip comprising:
a first base plate;
a first channel having an inlet and an outlet, the first channel being formed in a first surface of the first base plate;
a second base plate laminated on and bonded to the first base plate so as to face the first surface;
a first liquid holder formed in the first surface of the first base plate with the first channel and having a larger cross-sectional area than the first channel when orthogonally intersecting with a liquid feeding direction, the first liquid holder to store the first liquid and being capable of communicating with the first channel;
a gas inlet communicating with the inlet of the first channel and being opened to an outside of the microchannel chip, the gas inlet being provided in the first base plate so as to open to a second surface on an opposite side of the first surface;
a lid closing the gas inlet, the lid to be attached facing to the second surface;
a second channel having an inlet and an outlet; and
a second liquid holder capable of communicating with the first liquid holder, the second liquid holder to hold the second liquid, wherein
the outlet of the second channel is opened to the outside of the system microchannel chip,
the lid includes a fourth channel having an inlet and an outlet, the inlet of the fourth channel being opened to the outside of the microchannel chip and the outlet of the fourth channel being capable of being connected to the inlet of the second channel, and
when the lid is closed, the inlet of the fourth channel is closed while the outlet of the fourth channel is connected to the inlet of the second channel, gas is supplied to the inlet of the first channel and pushes out the first liquid from the first liquid holder toward the outlet of the first channel, and the pushed-out first liquid merges with the second liquid from the second liquid holder in the second channel.

7. The microchannel chip according to claim 6 , wherein
the second liquid holder is provided in an outlet end of the fourth channel, and an opening part to introduce the second liquid is formed in the lid so as to open to a surface facing the second surface, and
when the lid is closed, gas is supplied to the inlet of the fourth channel and pushes out the second liquid from the second liquid holder, and the pushed-out second liquid merges with the first liquid in the second channel.

8. The microchannel chip according to claim 4 , wherein
the second liquid holder is provided so as to protrude from a surface of the lid, the surface facing the second surface.

9. The microchannel chip according to claim 6 , wherein
the second liquid holder is provided so as to protrude from a surface of the lid, the surface facing the second surface.

Assignees

• Sekisui Chemical Co Ltd

Inventors

• Imamura Kazuhiko
• Inui Nobuhiko

Classifications

• B01L3/5027 Primary

  by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip · CPC title

• B01F25/422

  between stacked plates, e.g. grooved or perforated plates · CPC title

• B01F33/30

  Micromixers · CPC title

• B01L2300/0887

  Laminated structure · CPC title

• B01L2300/0867

  Multiple inlets and one sample wells, e.g. mixing, dilution · CPC title