Method of manufacturing nerve electrode

Patent metadata

Field	Value
Publication number	US-12420086-B2
Application number	US-201716471354-A
Country	US
Kind code	B2
Filing date	Mar 30, 2017
Priority date	Dec 19, 2016
Publication date	Sep 23, 2025
Grant date	Sep 23, 2025

Abstract

The present invention relates to a method of manufacturing a nerve electrode in which a conductive ink is inkjet printed on an electrospun polyimide fibrous sheet; and a nerve electrode manufactured by the manufacturing method.

First claim

The invention claimed is:

1. A method of manufacturing a nerve electrode for sensing nerve signals, the method comprising the steps of: 1) manufacturing a poly (amic acid) fibrous sheet by electrospinning poly (amic acid), wherein the poly (amic acid) is synthesized by polycondensation of pyromellitic dianhydride (PMDA) and 4,4′-oxydianiline in N,N-dimethylacetamide, and the polycondensation of the PMDA and the 4,4′-oxydianiline in the N,N-dimethylacetamide is performed under a temperature equal to or less than 4° C. for more than one hour; 2) manufacturing a polyimide fibrous sheet by heat-treating the poly (amic acid) fibrous sheet at a temperature of 300° C. to 400° C.; 3) thermally compressing the polyimide fibrous sheet at a temperature of 80° C. to 140° C. under a pressure of 600,000 N/m 2 to 900,000 N/m 2 for 30 minutes to 6 hours; 4) inkjet printing a conductive ink on the polyimide fibrous sheet thermally compressed in Step 3); 5) heat-treating the polyimide fibrous sheet on which the conductive ink is inkjet printed in Step 4) at a temperature of 140° C. to 220° C.; and 6) applying poly(3,4-ethylene dioxythiophene)/poly (styrenesulfonate) (PEDOT/PSS) on the inkjet printed conductive ink by an electrochemical polymerization method, thereby enhancing the sensing of the nerve signals.

2. The method of claim 1 , wherein the electrospinning in Step 1) is performed at a voltage of 10 kV to 40 kV.

3. The method of claim 1 , wherein the heat treatment in Step 2) is performed for 30 minutes to 6 hours.

4. The method of claim 1 , wherein the conductive ink in Step 4) comprises any one or more metal nanoparticles selected from the group consisting of a silver nanoparticle, a gold nanoparticle, a copper nanoparticle, an aluminum nanoparticle, a platinum nanoparticle, a titanium nanoparticle, an iridium nanoparticle, and an indium nanoparticle.

5. The method of claim 4 , wherein the conductive ink comprises the silver nanoparticle.

6. The method of claim 1 , wherein the heat treatment in Step 5) is performed for 30 minutes to 6 hours.

7. The method of claim 1 , further comprising a step of containing an anti-fibrotic drug by bringing the nerve electrode into contact with a solution in which the anti-fibrotic drug is dissolved.

Assignees

• Univ Industry Cooperation Group Kyung Hee Univ

Inventors

• Kwon Il Keun
• Heo Dong Nyoung
• Lee Dong Hyun
• Lee Sang Jin
• Heo Min

Classifications

• A61B5/24 Primary

  Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof · CPC title

• D10B2509/00

  Medical; Hygiene · CPC title

• D01F6/74

  from polycondensates of cyclic compounds, e.g. polyimides, polybenzimidazoles · CPC title

• D01D5/0007

  Electro-spinning (non-woven fabrics produced by electro-spinning D04H1/728) · CPC title

• B41M5/0064

  on plastics, horn, rubber, or other organic polymers · CPC title