Imaging composition comprising porous silicon micro-particles

Patent metadata

Field	Value
Publication number	US-12419974-B2
Application number	US-202117365134-A
Country	US
Kind code	B2
Filing date	Jul 1, 2021
Priority date	May 6, 2020
Publication date	Sep 23, 2025
Grant date	Sep 23, 2025

Abstract

The present disclosure describes an imaging composition including porous silicon microparticles, and more particularly, to a biological tissue imaging composition including a composite in which oxidized porous silicon microparticles and silver nanoparticles are combined. Since a biological tissue imaging agent of the present invention, which includes a composite of oxidized porous silicon microparticles and silver nanoparticles, continuously provides an image signal without spreading in the body as compared to conventional imaging agents, it is possible to increase surgical stability by accurately identifying target tissues in vivo in an affected area.

First claim

What is claimed is:

1. A composition for imaging of biological tissue by computed tomography (CT), comprising a composite in which oxidized porous silicon microparticles and silver nanoparticles are combined,
wherein the silver nanoparticles are bonded into pores of the oxidized porous silicon microparticles and attached to a surface of the oxidized porous silicon microparticles,
wherein the composite is dissolved in a mixture of glycerol and water in a ratio of 3:1,
wherein the composition has in vivo local area reactivity,
wherein a size of the porous silicon microparticles is in a range of 1 μm to 10 μm, and
wherein the composite includes elemental silicon, elemental oxygen, and elemental silver in a weight ratio of 100:100 to 120:15 to 30.

2. The composition of claim 1 , wherein the biological tissue is lung tissue.

3. A method of manufacturing a composition for imaging of biological tissue by computed tomography (CT) according to claim 1 , comprising steps of:
a) oxidizing porous silicon microparticles;
b) attaching silver nanoparticles to the oxidized silicon microparticles to create a composite; and
c) dissolving the composite in a mixture of glycerol and water in a ratio of 3:1,
wherein a size of the porous silicon microparticles is in a range of 1 μm to 10 μm, and
wherein the composite includes elemental silicon, elemental oxygen, and elemental silver in a weight ratio of 100:100 to 120:15 to 30.

4. The method of claim 3 , wherein the porous silicon microparticles oxidized in the step a) include an oxidized silicon (Si) framework (SiO 2 ).

5. The method of claim 3 , wherein, in the step b), the attaching of the silver nanoparticles is achieved using an aqueous silver bis-amine solution ([Ag(NH 3 ) 2 ) + ]).

6. The method of claim 3 , wherein the oxidizing is achieved using a borate.

Assignees

• Univ Industry Cooperation Group Kyung Hee Univ

Inventors

• Kim Dokyoung
• Kim Jaehoon

Classifications

• A61B6/032

  Transmission computed tomography [CT] · CPC title

• B82Y40/00

  Manufacture or treatment of nanostructures · CPC title

• B82Y30/00

  Nanotechnology for materials or surface science, e.g. nanocomposites · CPC title

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title

• C01P2004/03

  obtained by SEM · CPC title