Film-forming composition containing surfactant or surfactant and salt as whitening agent

Patent metadata

Field	Value
Publication number	US-12419812-B2
Application number	US-202418667925-A
Country	US
Kind code	B2
Filing date	May 17, 2024
Priority date	Jul 4, 2018
Publication date	Sep 23, 2025
Grant date	Sep 23, 2025

Abstract

[Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide.[Solution] Provided is a film, a capsule, and a film forming composition, characterized by comprising: a film-forming polymer; and a whitening agent including either a surfactant or both a surfactant and a salt, and characterized in that the surfactant is selected from a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, and a saponin.

First claim

We claim:

1. A single layer film comprising:
a single film-forming polymer as a base material of the single layer film, wherein the single film-forming polymer is either gelatin or pullulan; and
a whitening agent that includes either a surfactant or both a surfactant and a water-soluble salt,
wherein the surfactant is a fatty acid ester of polyhydric alcohol, polyethylene glycol, polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, and/or a saponin.

2. The single layer film according to claim 1 ,
wherein the fatty acid ester of polyhydric alcohol is a sucrose fatty acid ester, a sorbitan fatty acid ester, a glycerin fatty acid ester, or a polyoxysorbitan fatty acid ester;
the polyalkylene oxide derivative is a polyoxyethylene polyoxypropylene glycol, a polyoxyethylene alkyl ether, or a polyoxyethylene fatty acid ester; and
the saponin is either a triterpenoid saponin or steroid saponin.

3. The single layer film according to claim 1 , wherein the surfactant is selected from polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, sucrose monolaurate ester, sucrose palmitate ester, sorbitan monolaurate ester, Polysorbate 80, sodium lauryl sulfate, quillaja saponin, ginseng saponin, soybean saponin, sophora saponin, tea seed saponin, beet saponin, yucca saponin, or glycyrrhizin.

4. The single layer film according to claim 1 , wherein whiteness of the single layer film is adjusted by a total amount of the surfactant within a range from 0.5 parts by weight to 30 parts by weight while an amount, in dry weight, of the single film-forming polymer is defined as 100 parts by weight.

5. The single layer film according to claim 1 , wherein whiteness of the single layer film is adjusted by a total amount of the surfactant within a range from 0.7 parts by weight to 30 parts by weight while an amount, in dry weight, of the single film-forming polymer is defined as 100 parts by weight.

6. The single layer film according to claim 1 , wherein whiteness of the single layer film is adjusted by a total amount of the surfactant within a range from 1.0 part by weight to 30 parts by weight while an amount, in dry weight, of the single film-forming polymer is defined as 100 parts by weight.

7. The single layer film according to claim 1 , wherein whiteness of the single layer film is adjusted by a total amount of the surfactant within a range from 0.5 parts by weight to 15 parts by weight while an amount, in dry weight, of the single film-forming polymer is defined as 100 parts by weight.

8. The single layer film according to claim 1 , wherein the water-soluble salt to be added is a sodium salt and/or a potassium salt and/or an ammonium salt.

9. The single layer film according to claim 1 , wherein the water-soluble salt to be added to the single film-forming polymer is one or more salts selected from sodium malate, sodium succinate, sodium citrate, sodium polyphosphate, sodium bicarbonate, dipotassium hydrogenphosphate, disodium hydrogenphosphate, sodium dihydrogenphosphate, potassium carbonate, potassium dihydrogenphosphate, or sodium pyrophosphate dehydrate; and
the whiteness of the single layer film is changed by the total amount of the water-soluble salt within a range from 0.5 parts by weight to 30 parts by weight, while an amount, in dry weight, of the single film-forming polymer is defined as 100 parts by weight.

10. The single layer film according to claim 1 , wherein a color other than white is given to the single layer film by adding a dye or a pigment.

11. A capsule that is made of the single layer film according to claim 1 and that is suitable for oral delivery.

12. The capsule according to claim 11 , wherein the capsule is filled with a drug, a cosmetic or a health food product.

13. The capsule according to claim 11 , containing no white-color pigment.

14. The capsule according to claim 11 , wherein a combination of the single film-forming polymer and the surfactant is a combination of:
gelatin and sucrose monolaurate ester;
gelatin and a polyoxyethylene polyoxypropylene glycol;
gelatin and a saponin; or
pullulan and polyoxyethylene polyoxypropylene glycol.

15. The capsule according to claim 14 , wherein the saponin is quillaja saponin, ginseng saponin, soybean saponin, sophora saponin, tea seed saponin, beet saponin, yucca saponin, or glycyrrhizin.

16. A capsule that is made of the single layer film according to claim 10 and that is suitable for oral delivery.

17. The capsule according to claim 16 , wherein the capsule is filled with a drug, a cosmetic or a health food product.

18. The capsule according to claim 16 , containing no white-color pigment.

19. The capsule according to claim 16 , wherein a combination of the single film-forming polymer and the surfactant is a combination of:
gelatin and a sucrose monolaurate ester;
gelatin and a polyoxyethylene polyoxypropylene glycol;
gelatin and a saponin; or
pullulan and a polyoxyethylene polyoxypropylene glycol.

20. The capsule according to claim 19 , wherein the saponin is quillaja saponin, ginseng saponin, soybean saponin, sophora saponin, tea seed saponin, beet saponin, yucca saponin, or glycyrrhizin.

21. A film-forming composition forming the single layer film according to claim 1 , the film forming composition comprising:
the single film-forming polymer dissolved in water; and
the whitening agent.

22. A method of manufacturing a single layer film or a capsule suitable for oral delivery, the method comprising:
providing gelatin or pullulan as a single film-forming polymer to provide a base material of the single layer film or the capsule;
providing, as a whitening agent, either a surfactant or both a surfactant and a water-soluble salt;
combining the single film-forming polymer and the whitening agent to provide a film-forming composition; and
forming the film or capsule from the film-forming composition;
wherein the surfactant is a fatty acid ester of polyhydric alcohol, polyethylene glycol, polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, or a saponin.

Assignees

• Capsugel Belgium Nv

Inventors

• Sato Kaori
• Takubo Takahisa
• Doi Hitomi

Classifications

• A61K2800/92

  Oral administration · CPC title

• A61K2800/594

  Mixtures of polymers · CPC title

• A61K2800/43

  Pigments; Dyes · CPC title

• A61K2800/26

  Optical properties · CPC title

• A61K2800/10

  General cosmetic use · CPC title