Irreversible electroporation with shorted electrodes

Patent metadata

Field	Value
Publication number	US-12419683-B2
Application number	US-202117559558-A
Country	US
Kind code	B2
Filing date	Dec 22, 2021
Priority date	Dec 22, 2021
Publication date	Sep 23, 2025
Grant date	Sep 23, 2025

Abstract

A system for use with multiple electrodes coupled to respective spines of a probe includes multiple switches connected to the electrodes and configured to short different respective first subsets of the electrodes to each other and different respective second subsets of the electrodes to each other per different respective settings of the switches. The system further includes a processor configured to control the switches so as to alternate through the settings and, for each of the settings, cause a power generator to apply a voltage between the shorted first subset and the shorted second subset while the probe is deployed within a body of a subject. Other examples are also described.

First claim

The invention claimed is:

1. A system for use with multiple electrodes coupled to respective spines of a probe, the system comprising:
multiple switches connected to the electrodes and configured to short different respective first subsets of the electrodes to each other and different respective second subsets of the electrodes to each other per different respective settings of the switches; and
a processor, configured to:
control the switches so as to alternate through the settings;
for each of the settings, cause a power generator to apply a voltage between the shorted first subset of the electrodes and the shorted second subset of the electrodes; and
in at least one of the settings, cause the switches to short at least one respective first subset of the electrodes or one respective second subset of the electrodes to the spines to which the respective first subset of the electrodes or the respective second subset of the electrodes are coupled.

2. The system according to claim 1 , wherein the voltage has a constant positive amplitude for at least 100 ns and a constant negative amplitude for at least 100 ns.

3. The system according to claim 2 , wherein the positive amplitude and negative amplitude have the same magnitude.

4. The system according to claim 1 ,
wherein the spines include multiple half-spines extending between a tube and a distal end of the probe, and
wherein, per at least one of the settings, one or more electrodes in the first subset of the electrodes provided on a first set of adjacent half-spines are coupled to one another, and one or more electrodes in the second subset of the electrodes provided on a second set of adjacent half-spines are coupled to one another.

5. The system according to claim 4 , wherein the half-spines consist of N half-spines, wherein N includes an even integer of at least two or more, and wherein the first subset of the electrodes is coupled to N/2 of the half-spines and the second subset of the electrodes is coupled to another N/2 of the half-spines.

6. The system according to claim 1 , wherein the processor, in at least one of the settings, causes the switches to short the first subset of the electrodes to the spines to which the first subset of the electrodes is coupled, and short the second subset of the electrodes to the spines to which the second subset of the electrodes is coupled.

7. The system according to claim 1 , wherein, per at least one of the settings, the first subset of the electrodes is distal to the second subset of the electrodes.

8. A method for use with multiple electrodes coupled to respective spines of a probe, the method comprising:
by controlling multiple switches connected to the electrodes, causing the switches to short different respective first subsets of the electrodes to each other and different respective second subsets of the electrodes to each other per different respective settings of the switches;
for each of the settings, causing a power generator to apply a voltage between the shorted first subset of the electrodes and the shorted second subset of the electrodes; and
causing the switches to short at least one respective first subset of the electrodes or one respective second subset of the electrodes to the spines to which the respective first subset of the electrodes or the respective second subset of the electrodes are coupled.

9. The method according to claim 8 , wherein the voltage has a constant positive amplitude for at least 100 ns and a constant negative amplitude for at least 100 ns.

10. The method according to claim 8 ,
wherein the spines include multiple half-spines extending between a tube and a distal end of the probe, and
wherein, per at least one of the settings, one or more electrodes in the first subset of the electrodes provided on a first set of adjacent half-spines are coupled to one another, and one or more electrodes in the second subset of the electrodes provided on a second set of adjacent half-spines are coupled to one another.

11. The method according to claim 10 , wherein the half-spines consist of N half-spines, wherein N comprises an even integer of at least two or more, and wherein the first subset of the electrodes is coupled to N/2 of the half-spines and the second subset of the electrodes is coupled to another N/2 of the half-spines.

12. The method according to claim 8 , further comprising, in at least one of the settings, causing the switches to short the first subset of the electrodes to the spines to which the first subset of the electrodes is coupled, and short the second subset of the electrodes to the spines to which the second subset of the electrodes is coupled.

13. The method according to claim 8 , wherein, per at least one of the settings, the first subset of the electrodes is distal to the second subset of the electrodes.

14. A computer software product for use with multiple electrodes coupled to respective spines of a probe, the computer software product comprising a tangible non-transitory computer-readable medium in which program instructions are stored, which instructions, when read by a processor, cause the processor to:
control multiple switches connected to the electrodes so as to cause the switches to short different respective first subsets of the electrodes to each other and different respective second subsets of the electrodes to each other per different respective settings of the switches, and for each of the settings, cause a power generator to apply a voltage between the shorted first subset of the electrodes and the shorted second subset of the electrodes; and
in at least one of the settings, cause the switches to short at least one respective first subset of the electrodes or one respective second subset of the electrodes to the spines to which the respective first subset of the electrodes or the respective second subset of the electrodes are coupled.

15. The computer software product according to claim 14 , wherein the voltage has a constant positive amplitude for at least 100 ns and a constant negative amplitude for at least 100 ns.

16. The computer software product according to claim 14 ,
wherein the spines include multiple half-spines extending between a tube and a distal end of the probe, and
wherein, per at least one of the settings, one or more electrodes in the first subset of the electrodes provided on a first set of adjacent half-spines are coupled to one another, and one or more electrodes in the second subset of the electrodes provided on a second set of adjacent half-spines are coupled to one another.

17. The computer software product according to claim 16 , wherein the half-spines consist of N half-spines, wherein N comprises an even integer of at least two or more, and wherein the first subset of the electrodes is coupled to N/2 of the half-spines and the second subset of the electrodes is coupled to another N/2 of the half-spines.

18. The computer software product according to claim 14 , wherein, per at least one of the settings, the first subset of the electrodes is shorted to the spines to which the first subset of the electrodes is coupled, and the second subset of the electrodes is shorted to the spines to which the second subset of the electrodes is coupled.

19. The computer software product according to claim 14 , wherein, per at least one of the settings, the first subset is distal to the second subset.

20. A system for use with multiple electrodes coupled to respective spines of a probe, the system comprising:
wiring connected to the electrodes an

Assignees

• Biosense Webster Israel Ltd

Inventors

• Govari Assaf
• Beeckler Christopher Thomas
• Keyes Joseph Thomas
• Lichter Justin George

Classifications

• A61B2018/1475

  Electrodes retractable in or deployable from a housing · CPC title

• A61B2018/00916

  with means for switching or controlling the main function of the instrument or device · CPC title

• A61B2018/00767

  Voltage · CPC title

• A61B2018/00613

  Irreversible electroporation · CPC title

• A61B2018/00351

  Heart · CPC title