Methods, devices, and systems for mixing fluids
US-2016195457-A1 · Jul 7, 2016 · US
US12415180B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12415180-B2 |
| Application number | US-201917312431-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 20, 2019 |
| Priority date | Dec 20, 2018 |
| Publication date | Sep 16, 2025 |
| Grant date | Sep 16, 2025 |
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Official abstract text for this publication.
A pipette tip extension attachable to a pipette tip is disclosed. The pipette tip extension has a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip. The pipette tip extension also has a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, and one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.
Opening claim text (preview).
The invention claimed is: 1. A pipette tip extension attachable to a pipette tip, the pipette tip extension comprising: a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end, the exterior wall having an outer side and an inner side and forming at the proximal end a reception aperture for inserting a pipette tip, a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, and one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity, the distance elements being dimensioned to establish a fluid uptake area adjacent to the inner side of the exterior wall and the bottom, the fluid uptake area extending from the bottom up to the reception aperture and being in fluid connection with the surrounding atmosphere at the reception aperture; and a constriction element for controlling an insertion depth of a pipette tip within the pipette tip extension, the constriction element defining a gap with a gap height between a distal end of an inserted pipette tip and the distal end of the pipette tip extension, thereby establishing a fluid connection between an inner cavity of an inserted pipette tip and the fluid uptake area, wherein the constriction element is formed by one or more spacing blocks arranged at the bottom in the inner cavity of the pipette tip extension. 2. The pipette tip extension according to claim 1 , wherein the bottom and the exterior wall are formed as one piece. 3. The pipette tip extension according to claim 1 , wherein the bottom and the exterior wall are impervious to fluids. 4. The pipette tip extension according to claim 1 , wherein one or more of the at least one or more distance elements are arranged flush with respect to the proximal end of the pipette tip extension, and/or one or more of the at least one or more distance elements are arranged offset with respect to the proximal end of the pipette tip extension. 5. The pipette tip extension according to claim 1 , comprising at least two of the one or more distance elements. 6. The pipette tip extension according to claim 1 , wherein at least one of the at least one or more distance elements is configured as an elongated bar which extends along a direction from the proximal end towards the distal end of the pipette tip extension. 7. The pipette tip extension according to claim 1 , wherein the exterior wall is a circumferential wall which tapers towards the lower end of the pipette tip extension. 8. An assembly comprising: a pipette tip for aspirating and/or dispensing a liquid, a pipette tip extension attached to the pipette tip, the pipette tip extension comprising: a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end, the exterior wall having an outer side and an inner side and forming at the proximal end a reception aperture for inserting a pipette tip, a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, and one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity, the distance elements being dimensioned to establish a fluid uptake area adjacent to the inner side of the exterior wall and the bottom, the fluid uptake area extending from the bottom up to the reception aperture and being in fluid connection with the surrounding atmosphere at the reception aperture; and a constriction element for controlling an insertion depth of a pipette tip within the pipette tip extension, the constriction element defining a gap with a gap height between a distal end of an inserted pipette tip and the distal end of the pipette tip extension, thereby establishing a fluid connection between an inner cavity of an inserted pipette tip and the fluid uptake area, wherein the constriction element is formed by one or more spacing blocks arranged at the bottom in the inner cavity of the pipette tip extension.
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