Flash radiotherapy accelerator system

Patent metadata

Field	Value
Publication number	US-12415092-B2
Application number	US-202217575074-A
Country	US
Kind code	B2
Filing date	Jan 13, 2022
Priority date	Jan 13, 2021
Publication date	Sep 16, 2025
Grant date	Sep 16, 2025

Abstract

Methods, devices and systems for ultra-high dose radiotherapy are disclosed. The described techniques rely in-part on active switching control of a photoconductive switch during the time the accelerator is accelerating charged particles to produce the output radiation at the desired dose rates. One radiotherapy system includes a particle accelerator configured to receive charged particles from a pulsed source. The particle accelerator includes a pipe configured to allow the charged particles to pass through as a beam, a magnetic core positioned proximate to the pipe and coupled to the pulsed source, and at least one multilayer insulator positioned adjacent to the pipe and the magnetic core. The system also includes a photoconductive switch coupled to the particle accelerator and configured to supply the particle accelerator with a plurality of voltage pulses.

First claim

What is claimed is:

1. An accelerator system for use in a radiotherapy system, comprising:
a particle accelerator configured to receive charged particles from a pulsed source, wherein the particle accelerator comprises:
a pipe configured to allow the charged particles to pass through as a beam,
a magnetic core positioned proximate to the pipe and coupled to the pulsed source, and
a multilayer insulator positioned adjacent to the pipe and the magnetic core; and

a photoconductive switch coupled to the particle accelerator and configured to supply the particle accelerator with a plurality of voltage pulses, wherein the particle accelerator is operable to accelerate the charged particles based on the plurality of voltage pulses, and to produce an output beam comprising one or more radiation pulses for radiotherapy,
wherein the photoconductive switch includes a doped crystalline material that is configured to receive a voltage from an energy source to establish an electric field across the doped crystalline material, and
wherein the photoconductive switch is configured to receive light from a light source and to operate in response to the received light, the photoconductive switch being operable in a linear mode of operation in response to the received light,
wherein the accelerator system is operable to:
produce output radiation pulses with an instantaneous dose rate that exceeds 1.8×10 5 Gy/s,
administer a totality of the output radiation pulses that constitute a required dose in less than 200 ms,
produce the output radiation pulses with an average dose rate greater than 100 Gy/s, and
irradiate an entirety of a target region with levels above both the instantaneous dose rate and the average dose rate.

2. The accelerator system of claim 1 , wherein the particle accelerator comprises:
a solenoid coupled to the magnetic core that is positioned around the pipe, wherein the solenoid is positioned proximate to the magnetic core and the multilayer insulator, wherein the pulsed source is coupled to the magnetic core via the solenoid to enable the particle accelerator to receive the charged particles.

3. The accelerator system of claim 1 , wherein the light source includes one or more laser sources.

4. The accelerator system of claim 1 , wherein the photoconductive switch is operable to modify one or more of an amplitude, shape, spacing, number or width of the plurality of voltage pulses supplied to the particle accelerator.

5. The accelerator system of claim 1 , wherein the accelerator system has a three-dimensional footprint of less than or equal to 100 cubic meters.

6. The accelerator system of claim 1 , wherein the particle accelerator is an induction linear accelerator.

7. The accelerator system of claim 1 , wherein the charged particles comprise electrons.

8. The accelerator system of claim 1 , wherein the pipe is configured to accommodate multiple beams of charged particles.

9. A method for producing output radiation in a radiotherapy system, comprising:
receiving, at a particle accelerator of a particle accelerator system, a beam of charged particles from a particle source, wherein the particle accelerator comprises a pipe configured to allow the beam of charged particles to pass through, a magnetic core positioned proximate to the pipe and coupled to a pulsed source, and an insulator positioned adjacent to the pipe and the magnetic core, wherein the particle accelerator system further includes a photoconductive switch coupled to the particle accelerator that comprises a doped crystalline material that is configured to receive a voltage from an energy source to establish an electric field across the doped crystalline material;
producing a plurality of voltage pulses by the photoconductive switch in response to receiving light that is incident on the doped crystalline material; and
accelerating the beam of charged particles by the particle accelerator based on the plurality of voltage pulses to produce one or more output radiation beams for flash radiotherapy,
wherein the method further comprises:
producing the one or more output radiation beams that include radiation pulses with an instantaneous dose rate that exceed 1.8×105 Gy/s,
administering a required dose in less than 200 ms,
producing the one or more output radiation beams having radiation pulses with an average dose rate greater than 100 Gy/s, and
irradiating an entirety of a target region with levels above both the instantaneous dose rate and the average dose rate.

10. The method of claim 9 , wherein the photoconductive switch is configured to receive the light from a light source and to operate in response to the received light, the photoconductive switch being operable in a linear mode of operation in response to the received light.

11. The method of claim 10 , wherein the light source includes one or more laser sources.

12. The method of claim 9 , further comprising:
measuring a radiation amount administered to the entirety of the target region.

13. The method of claim 9 , comprising:
modifying an instantaneous dose rate or average dose rate of the one or more output radiation beams based on the plurality of voltage pulses produced by the photoconductive switch.

14. The method of claim 9 , wherein the particle accelerator is an induction linear accelerator.

15. The method of claim 9 , wherein the beam of charged particles comprise electrons.

16. The method of claim 9 , wherein the pipe is configured to accommodate multiple beams of charged particle beams.

17. The method of claim 9 , wherein the particle accelerator system has a three-dimensional footprint of less than or equal to 100 cubic meters, and the method further comprises:
operating the particle accelerator system in a clinical setting.

Assignees

• L Livermore Nat Security Llc
• Opcondys Inc

Inventors

• Sampayan Stephen E
• Caporaso George James
• Chen Yu-Jiuan
• Sampayan Kristin Cortella

Classifications

• H05H7/22

  Details of linear accelerators, e.g. drift tubes (H05H7/02 - H05H7/20 take precedence) · CPC title

• A61N5/1078

  Fixed beam systems · CPC title

• A61N2005/1089

  Electrons · CPC title

• H05H2277/11

  Radiotherapy · CPC title

• A61N2005/1088

  generated by laser radiation · CPC title