Methods for systemically delivering polypeptides and microorganisms therefor
US-10376563-B1 · Aug 13, 2019 · US
Methods and compositions to treat and prevent infection
US12414971B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12414971-B2 |
| Application number | US-201917279386-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 25, 2019 |
| Priority date | Sep 25, 2018 |
| Publication date | Sep 16, 2025 |
| Grant date | Sep 16, 2025 |
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- Title
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Abstract
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In certain aspects, described herein are methods, bacteria, and compositions for the treatment of bacterial infections. Specifically, bacteria that can upregulate antimicrobial peptides, e.g., Reg3, within a subject have been identified and methods of using such bacteria to treat infections is described.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of increasing the levels of a Reg3 peptide in a subject in need thereof, comprising administering to the subject bacteria strain Ruminococcus gnavus, Lactobacillus reuteri or a combination thereof in an amount effective to increase the level of Reg3 peptide in the subject. 2. The method of claim 1 , wherein the Reg3 peptide is Reg3a, Reg3γ, or Reg3β. 3. The method of claim 1 , wherein the subject has an inflammatory condition. 4. The method of claim 1 , wherein the subject has a bacterial infection. 5. The method of claim 4 , wherein the bacterial infection is a gram-negative or gram-positive bacterium. 6. The method of claim 5 , wherein the bacteria is gram positive and selected from the group consisting of an enterococci infection, a vancomycin-resistant enterococci (VRC) infection, a Clostridium difficile infection, a Staphylococcus aureus infection, a methicillin-resistant Staphylococcus aureus (MRSA) infection, and a combination thereof. 7. The method of claim 4 , wherein the bacterial infection is caused by an antibiotic resistant pathogen. 8. The method of claim 1 , wherein the Ruminococcus gnavus, Lactobacillus reuteri or combination thereof is in a composition formulated for oral administration or rectal administration. 9. The method of claim 1 , wherein the Ruminococcus gnavus, Lactobacillus reuteri , or combination thereof is formulated for topical or inhalant administration. 10. The method of claim 1 , wherein the Ruminococcus gnavus, Lactobacillus reuteri , or combination thereof are live, replication competent bacteria. 11. The method of claim 1 , wherein the Ruminococcus gnavus, Lactobacillus reuteri , or combination thereof are not live, replication competent bacteria. 12. The method of claim 11 , wherein the Ruminococcus gnavus, Lactobacillus reuteri , or combination thereof is in the form of a bacterial lysate. 13. The method of claim 1 , wherein the Reg3 is Reg3γ and increases the stem cell proliferation within the gut of the subject.
Assignees
Inventors
Classifications
Reuteri · CPC title
Bacteria or derivatives thereof, e.g. probiotics · CPC title
Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs · CPC title
- A61K35/747Primary
Lactobacilli, e.g. L. acidophilus or L. brevis · CPC title
- A61P31/04Primary
Antibacterial agents · CPC title
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Frequently asked questions
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- What does patent US12414971B2 cover?
- In certain aspects, described herein are methods, bacteria, and compositions for the treatment of bacterial infections. Specifically, bacteria that can upregulate antimicrobial peptides, e.g., Reg3, within a subject have been identified and methods of using such bacteria to treat infections is described.
- Who is the assignee on this patent?
- Univ Duke, Harvard College, Childrens Medical Center
- What technology area does this patent fall under?
- Primary CPC classification A61K35/747. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 16 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).