Apparatus and methods for controlled clot aspiration

Patent metadata

Field	Value
Publication number	US-12414784-B1
Application number	US-202519030306-A
Country	US
Kind code	B1
Filing date	Jan 17, 2025
Priority date	Jul 24, 2018
Publication date	Sep 16, 2025
Grant date	Sep 16, 2025

Abstract

A dynamic aspiration system includes a connecting tube, a vacuum source, a pressure source, an aspiration catheter, a first controllable valve to control a level of negative pressure provided by the vacuum source, a second controllable valve to control a level of positive pressure provided by the pressure source, pressure sensors, and a controller. The controller modulates the controllable valves to generate pressure pulses, determines, for each of the pressure pulses, a degree of success corresponding to a change in a flow in the aspiration catheter or the connecting tube responsive to the pressure pulse, identifies one or more first pressure pulses determined to have the highest degrees of success, and modulates the controllable valves to generate the first pressure pulses in one or more pressure pulse cycles.

First claim

What is claimed is:

1. A dynamic aspiration system for use with a vacuum source, a pressure source, and an aspiration catheter, the system comprising:
a connecting tube configured to place the vacuum source, the pressure source, and the aspiration catheter in fluid communication;
a first controllable valve configured to control a level of negative pressure in the connecting tube provided by the vacuum source;
a second controllable valve configured to control a level of positive pressure in the connecting tube provided by the pressure source;
one or more pressure sensors configured to detect one or more pressure sensor readings associated with a flow state within the aspiration catheter or the connecting tube; and
a controller configured to:
modulate one or more of the controllable valves to generate a plurality of pressure pulses, wherein one or more of the pressure pulses generates one or more pressure differentials within the aspiration catheter or the connecting tube;
determine, for each of the plurality of pressure pulses, a degree of success corresponding to a change in a flow in the aspiration catheter or the connecting tube responsive to the pressure pulse;
identify, from the plurality of pressure pulses, one or more first pressure pulses determined to have the highest degrees of success of the plurality of pressure pulses; and
modulate one or more of the controllable valves to generate the one or more first pressure pulses in one or more pressure pulse cycles.

2. The dynamic aspiration system of claim 1 , wherein one or more of the controllable valves are modulated according to a first pressure pulse protocol to generate the plurality of pressure pulses.

3. The dynamic aspiration system of claim 2 , wherein the first pressure pulse protocol is based on the one or more pressure sensor readings.

4. The dynamic aspiration system of claim 2 , wherein the first pressure pulse protocol is predetermined from a library of pressure pulse protocols.

5. The dynamic aspiration system of claim 4 , wherein the library of pressure pulse protocols is associated with specified time periods corresponding to one or more of static aspiration, full aspiration, or occlusion detection.

6. The dynamic aspiration system of claim 1 , wherein each determined degree of success corresponds to an amount of increased flow responsive to the corresponding pressure pulse.

7. The dynamic aspiration system of claim 1 , wherein the first controllable valve is a vacuum valve between the vacuum source and the connecting tube, and wherein the second controllable valve is a pressure valve between the pressure source and the connecting tube.

8. The dynamic aspiration system of claim 1 , wherein modulating one or more of the controllable valves to generate the plurality of pressure pulses comprises opening and closing one or more of the first controllable valve or the second controllable valve in a specific sequence.

9. The dynamic aspiration system of claim 8 , wherein opening the second controllable valve increases a pressure level within the aspiration catheter or the connecting tube.

10. The dynamic aspiration system of claim 9 , wherein the opening of the second controllable valve further increases a pressure level at a distal tip of the aspiration catheter.

11. The dynamic aspiration system of claim 9 , wherein the pressure source has a pressure level greater than an atmospheric pressure level.

12. The dynamic aspiration system of claim 1 , wherein the connecting tube is configured to be linear in an unconstrained configuration, and wherein the connecting tube is further configured to have a first end connected to the vacuum source and a second end connected to the aspiration catheter.

13. The dynamic aspiration system of claim 12 , further comprising a three-way joint configured to place the pressure source in fluid communication with the connecting tube.

14. The dynamic aspiration system of claim 13 , wherein the three-way joint is positioned proximally relative to the second end of the connecting tube.

15. The dynamic aspiration system of claim 13 , wherein the three-way joint is a T-joint, a Y-joint, or an angled joint.

16. The dynamic aspiration system of claim 1 , wherein the flow state within the aspiration catheter or the connecting tube is one of a plurality of flow states comprising a restricted flow state, an unrestricted flow state, a clogged flow state, or a partially clogged flow state.

17. The dynamic aspiration system of claim 16 , wherein the generated pressure differentials increase in magnitude when the flow state is the clogged flow state or the partially clogged flow state.

18. The dynamic aspiration system of claim 16 , wherein a magnitude of the generated pressure differentials is held constant when the flow state is the restricted flow state.

19. The dynamic aspiration system of claim 1 , wherein a frequency and an amplitude of one or more of the generated pressure differentials is selected from a library of pressure pulses.

20. The dynamic aspiration system of claim 19 , wherein the one or more first pressure pulses are determined to have the highest degrees of success based at least in part on an increase in flow responsive to the corresponding pressure pulse.

Assignees

• Penumbra Inc

Inventors

• Teigen Scott
• Loisel Steven
• Pons Stephen
• Tompkins Ben

Classifications

• A61M2205/3344

  Measuring or controlling pressure at the body treatment site · CPC title

• A61B17/00

  Surgical instruments, devices or methods (A61B18/00 takes precedence; dental tools A61C3/00; eye surgery A61F9/007; ear surgery A61F11/20) · CPC title

• A61M1/75

  Intermittent or pulsating suction (A61M1/63, A61M1/772 take precedence) · CPC title

• A61M1/774

  Handpieces specially adapted for providing suction as well as irrigation, either simultaneously or independently · CPC title

• A61B17/32037

  for removing obstructions from inner organs or blood vessels, e.g. for atherectomy · CPC title