Virus collection matrix

Patent metadata

Field	Value
Publication number	US-12411137-B2
Application number	US-202117336883-A
Country	US
Kind code	B2
Filing date	Jun 2, 2021
Priority date	Dec 25, 2020
Publication date	Sep 9, 2025
Grant date	Sep 9, 2025

Abstract

The present invention provides a virus collection matrix, including: a porous gel or fibrous structure formed by a positively charged polymer material; and a plurality of ACE 2 receptors. The plurality of ACE 2 receptors are negatively charged, and distributed and covered on the surface of the porous gel or fibrous structure. The whole virus collection matrix is positively charged.

First claim

What is claimed is:

1. A virus collection matrix for collecting target virus in air, comprising:
a porous gel or fibrous structure formed by a positively charged polymer material; and
a plurality of ACE 2 receptors, the plurality of ACE 2 receptors are negatively charged, and distributed and covered on a surface of the porous gel or fibrous structure, and
wherein a whole of the virus collection matrix comprising the negatively charged ACE 2 receptors is positively charged.

2. The virus collection matrix according to claim 1 , wherein the polymer material is chitosan, and the porous gel or fibrous structure is formed by electrostatic force or EDC cross-linking reaction between molecules of chitosan.

3. The virus collection matrix according to claim 1 , wherein the plurality of ACE 2 receptors are connected to the porous gel or fibrous structure by electric charge attraction or chemical grafting.

4. The virus collection matrix according to claim 1 , wherein the virus collection matrix is applicable for collecting the target viruses including novel coronavirus (covid-19), SARS virus, or any other coronavirus containing spike proteins, and when the target virus passes through the virus collection matrix, the target virus is capable of being detained on the surface of the porous gel or fibrous structure.

5. The virus collection matrix according to claim 4 , wherein in response to the virus collection matrix detaining the target virus, the virus collection matrix exhibits a spectral characteristic peak of the spike proteins when being optically analyzed by a spectrometer.

6. The virus collection matrix according to claim 5 , wherein the virus collection matrix exhibits an absorption peak of ultraviolet spectrum at 280-290 nm, and an absorption peak of near infrared spectrum at 900-1400 nm.

7. The virus collection matrix according to claim 5 , wherein the virus collection matrix exhibits a concentration of resolution with respect to the spike proteins is lower than 3.5 uM when being optically analyzed.

8. The virus collection matrix according to claim 5 , wherein the virus collection matrix exhibits a concentration of resolution with respect to the spike proteins lower than 10 nM when being optically analyzed.

9. The virus collection matrix according to claim 1 , wherein the virus collection matrix is a chip or a filter material.

10. The virus collection matrix according to claim 1 , wherein the virus collection matrix is configured to be combined to other device or equipment so as to filter air, collect virus, or conduct combination thereof when air flows through.

11. The virus collection matrix according to claim 1 , wherein the porous gel or fibrous structure is formed of the polymer material through lyophilization, 3D printing, electrospinning nanofiber, cross-linking reaction, electrochemistry or spray coating.

12. The virus collection matrix according to claim 1 , wherein the virus collection matrix further includes a carrier, and the porous gel or fibrous structure is formed on the carrier.

13. The virus collection matrix according to claim 12 , wherein the carrier is a textile fiber or teflon.

Assignees

• National Yang Ming Chiao Tung Univ

Inventors

• Liu Dean-Mo
• Chang Yung-Hsin
• Wang Wen-Lien
• Liu shu-han

Classifications

• C12Y304/17023

  Angiotensin-converting enzyme 2 (3.4.17.23) · CPC title

• C12N9/485

  Exopeptidases (3.4.11-3.4.19) · CPC title

• G01N15/075

  by optical means · CPC title

• G01N33/56983

  Viruses · CPC title

• G01N2333/165

  Coronaviridae, e.g. avian infectious bronchitis virus · CPC title