3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
US-2023287037-A1 · Sep 14, 2023 · US
Neuroactive steroids and their methods of use
US12410210B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12410210-B2 |
| Application number | US-202418616995-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 26, 2024 |
| Priority date | Dec 5, 2018 |
| Publication date | Sep 9, 2025 |
| Grant date | Sep 9, 2025 |
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Abstract
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Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R 19 , R 5 , R 3a , R 1a , R 1b , R 2a , R 2b , R 4a , R 4b , R 6a , R 6b , R 7a , R 7b , R 11a , R 11b , R 12a , R 12b , R 18 , R D , and q are defined herein. L is selected from the group consisting of: wherein A indicates the point of attachment at C17 and wherein X is selected from the group consisting of —C(O)N(R 55a )(R 55b ), —N(R 55a )(R 55b ), —N(R 55b )C(O)(R 55a ), and R 55C wherein R 55c is carbon-bound substituted or unsubstituted heteroaryl or substituted or unsubstituted aryl. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
First claim
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What is claimed: 1. A compound selected from Exa- Structure mple 305 306 317 318 325 326 51 52 355 and 356 2. A compound selected from Example Structure 305 317 325 51 and 355 3. A compound selected from Example Structure 306 318 326 52 356
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Classifications
containing nitrile radicals, including thiocyanide radicals · CPC title
with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group · CPC title
Drugs for disorders of the nervous system · CPC title
containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin (digitoxin {A61K31/7048}) · CPC title
the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives · CPC title
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- What does patent US12410210B2 cover?
- Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R 19 , R 5 , R 3a , R 1a , R 1b , R 2a , R 2b , R 4a , R 4b , R 6a , R 6b , R 7a , R 7b , R 11a , R 11b , R 12a , R 12b , R 18 , R D , and q are defined herein. L is selected from the group consisting of: wherein A indicates the point of attachment at C17 and wherein X is selected from the group …
- Who is the assignee on this patent?
- Sage Therapeutics Inc
- What technology area does this patent fall under?
- Primary CPC classification C07J43/003. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 09 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 7 related publications on this page (citations in our corpus or others sharing the same primary CPC).