Multiple layer devices for treatment of vascular defects

Patent metadata

Field	Value
Publication number	US-12408925-B2
Application number	US-202318221559-A
Country	US
Kind code	B2
Filing date	Jul 13, 2023
Priority date	Mar 11, 2020
Publication date	Sep 9, 2025
Grant date	Sep 9, 2025

Abstract

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a first permeable shell and a second permeable shell, where the second permeable shell sits within an interior cavity of the first permeable shell. The first and second permeable shells may each be made from a plurality of elongate filaments that are woven together to form a mesh. The mesh of the first permeable shell may have a larger mesh density and be softer than the mesh of the second permeable shell.

First claim

What is claimed is:

1. A method for treating a cerebral aneurysm having an interior cavity and a neck, comprising the steps of:
advancing an implant coupled to a pusher in a microcatheter to a region of interest in a cerebral artery, wherein the implant comprises:
a first permeable shell having a proximal end, a distal end, a radially constrained elongated state configured for delivery within a lumen of the microcatheter, an expanded state with a longitudinally shortened configuration relative to the radially constrained state, and a first plurality of elongate filaments that are woven together to form a mesh, the expanded state defining an interior cavity, wherein each of the filaments of the plurality of filaments of the first permeable shell has a diameter between about 0.0005″ and about 0.00075″, and wherein the first plurality of elongate filaments comprises 96 filaments or more; and
a second permeable shell having a proximal end, a distal end, a radially constrained elongated state configured for delivery within the lumen of the microcatheter, an expanded state with a longitudinally shortened configuration relative to the radially constrained state, and a second plurality of elongate filaments that are woven together to form a mesh,
wherein the second permeable shell sits within the interior cavity of the first permeable shell, wherein the mesh of the first permeable shell has a different braid angle than the mesh of the second permeable shell, and wherein each of the second plurality of elongate filaments has a larger diameter than each of the first plurality of elongate filaments;

advancing the pusher to advance the implant out of a distal end of the microcatheter, wherein a substantial length of the first permeable shell exits the microcatheter before the second permeable shell;
deploying the implant within the cerebral aneurysm, wherein each of the first and second permeable shells expands to its expanded state in the interior cavity of the aneurysm; and
withdrawing the microcatheter from the region of interest after deploying the implant.

2. The method of claim 1 , wherein the first permeable shell begins to deploy to the expanded state of the first permeable shell before the second permeable shell begins to deploy to the expanded state of the second permeable shell.

3. The method of claim 1 , wherein a height of the expanded state of the second permeable shell is substantially the same as a height of the expanded state of the first permeable shell.

4. The method of claim 1 , wherein each of the first plurality of filaments forming the first permeable shell has a proximal and distal end, wherein the proximal ends of the first plurality of filaments of the first permeable shell are gathered in a proximal marker band.

5. The method of claim 4 , wherein each of the second plurality of filaments forming the second permeable shell has a proximal and distal end, wherein the proximal ends of the second plurality of filaments of the second permeable shell are gathered in the proximal marker band.

6. The method of claim 4 , wherein the distal ends of the first plurality of filaments forming the first permeable shell are gathered in a first distal marker band.

7. The method of claim 6 , wherein the distal ends of the second plurality of filaments forming the second permeable shell are gathered in a second distal marker band.

8. The method of claim 1 , wherein the first and second permeable shells each have an average mesh density, and wherein the average mesh density of the second permeable shell is smaller than the average mesh density of the first permeable shell.

9. The method of claim 1 , wherein the mesh of the first permeable shell is softer than the mesh of the second permeable shell.

10. The method of claim 1 , wherein each of the filaments of the second plurality of elongate filaments has a diameter between about 0.00125″ and about 0.002″.

11. The method of claim 1 , wherein the first permeable shell is made from about 108 filaments or more.

12. The method of claim 1 , wherein the second permeable shell is made from between about 18 and 48 filaments.

13. The method of claim 1 , wherein a smaller number of filaments form the second permeable shell than the first permeable shell.

14. The method of claim 1 , wherein the first and second permeable shells each have an average pore size, and wherein the average pore size of the second permeable shell is larger than the average pore size of the first permeable shell.

15. The method of claim 14 , wherein the average pore size of the second permeable shell is between about 150 microns and about 1 mm.

16. The method of claim 14 , wherein the average pore size of the first permeable shell is between about 100 microns and about 400 microns.

17. The method of claim 14 , wherein the average pore size of the second permeable shell is at least about 2 greater than the average pore size of the first permeable shell.

18. The method of claim 1 , wherein the average mesh density of the second permeable shell is at least about 2 smaller than the average mesh density of the first permeable shell.

19. The method of claim 1 , wherein the first permeable shell has a first braid angle and the second permeable shell has a second braid angle, and wherein the first braid angle is higher than the second braid angle.

Assignees

• Microvention Inc

Inventors

• Vu John
• Luu Nathan
• Hewitt Todd
• Tran Hung P

Classifications

• A61B17/12113 Primary

  within an aneurysm · CPC title

• A61B2090/3966

  Radiopaque markers visible in an X-ray image · CPC title

• A61B2017/1205

  Introduction devices · CPC title

• A61B17/12172 Primary

  having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526) · CPC title