Predicting efficacies and improving skincare treatment outcomes based on responder/non-responder information

Patent metadata

Field	Value
Publication number	US-12406771-B2
Application number	US-202217784079-A
Country	US
Kind code	B2
Filing date	Apr 29, 2022
Priority date	Apr 30, 2021
Publication date	Sep 2, 2025
Grant date	Sep 2, 2025

Abstract

In some embodiments, techniques for improving treatment outcomes are provided. A computing system measures at least one skin condition for a subject. The computing system receives a plurality of types of omics data for the subject. For each type of omics data, the computing system uses at least one classifier associated with the type of omics data to determine whether the subject is in at least one responder category. The computing system predicts treatment outcomes for the at least one skin condition for the subject for a plurality treatments based on the at least one responder category. The computing system determines a skincare regimen based on the predicted treatment outcomes.

First claim

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. A computer-implemented method of improving treatment outcomes, the method comprising:
measuring, by a computing system, at least one skin condition for a subject to obtain a first measurement;
receiving, by the computing system, a plurality of types of omics data for the subject;
for each type of omics data, using, by the computing system, at least one classifier associated with the type of omics data to determine whether the subject is in at least one responder category by providing the type of omics data as input to the at least one classifier, wherein the responder category indicates whether the subject is predicted to respond to a particular skincare product ingredient associated with the responder category;
predicting, by the computing system, treatment outcomes for the at least one skin condition for the subject for a plurality of treatments based on the at least one responder category using stored data indicating how a given skincare treatment will affect a given clinical sign of aging for subjects in the at least one responder category;
determining, by the computing system, a skincare regimen based on the predicted treatment outcomes;
measuring, by the computing system, the at least one skin condition for the subject after application of the skincare regimen to obtain a second measurement; and
updating, by the computing system, the at least one classifier based on a difference between the first measurement and the second measurement.

2. The computer-implemented method of claim 1 , wherein the types of omics data include two or more of genomic data, exomic data, transcriptomic data, epigenomic data, proteomic data, metabolomic data, and microbiomic data.

3. The computer-implemented method of claim 1 , wherein the at least one responder category includes at least one of:
a retinol responder category;
a proxylane responder category;
a vitamin C responder category;
a hyaluronic acid responder category;
an endolysin responder category; and
a lipohydroxy acid (LHA) responder category.

4. The computer-implemented method of claim 1 , wherein at least one responder category changes over time for the subject.

5. The computer-implemented method of claim 4 , wherein the at least one responder category that changes over time for the subject changes based on a date in a physiological cycle for the subject.

6. The computer-implemented method of claim 5 , wherein the physiological cycle for the subject is a menstrual cycle.

7. The computer-implemented method of claim 1 , wherein the at least one skin condition includes at least one of a clinical sign of aging, a medical condition, and a skin tone.

8. The computer-implemented method of claim 1 , further comprising:
providing, by the computing system, the type of omics data as input to the updated at least one classifier to create an updated determination of whether the subject is in the at least one responder category;
predicting, by the computing system, updated treatment outcomes for the at least one skin condition for the subject for the plurality of treatments based on the updated determination;
determining, by the computing system, an updated skincare regimen based on the predicted updated treatment outcomes; and
applying the updated skincare regimen.

9. A computing system, comprising:
a responder engine including computational circuitry configured to:
measure at least one skin condition for a subject to obtain a first measurement;
receive a plurality of types of omics data for the subject; and
for each type of omics data, use at least one classifier associated with the type of omics data to determine whether the subject is in at least one responder category by providing the type of omics data as input to the at least one classifier, wherein the responder category indicates whether the subject is predicted to respond to a particular skincare product ingredient associated with the responder category;

a treatment recommendation engine including computational circuitry configured to:
predict treatment outcomes for the at least one skin condition for the subject for a plurality of treatments based on the at least one responder category using stored data indicating how a given skincare treatment will affect a given clinical sign of aging for subjects in the at least one responder category;
determine a skincare regimen based on the predicted treatment outcomes;
measure the at least one skin condition for the subject after application of the skincare regimen to obtain a second measurement; and
update the at least one classifier based on a difference between the first measurement and the second measurement.

10. The computing system of claim 9 , wherein the types of omics data include two or more of genomic data, exomic data, transcriptomic data, epigenomic data, proteomic data, metabolomic data, and microbiomic data.

11. The computing system of claim 9 , wherein the at least one responder category includes at least one of:
a retinol responder category;
a proxylane responder category;
a vitamin C responder category;
a hyaluronic acid responder category;
an endolysin responder category; and
a lipohydroxy acid (LHA) responder category.

12. The computing system of claim 9 , wherein at least one responder category changes over time for the subject.

13. The computing system of claim 12 , wherein the at least one responder category that changes over time for the subject changes based on a date in a physiological cycle for the subject.

14. The computing system of claim 13 , wherein the physiological cycle for the subject is a menstrual cycle.

15. The computing system of claim 13 , wherein the at least one skin condition includes at least one of a clinical sign of aging, a medical condition, and a skin tone.

16. A non-transitory computer-readable medium having computer-executable instructions stored thereon that, in response to execution by one or more processors of a computing system, cause the computing system to perform actions comprising:
measuring, by the computing system, at least one skin condition for a subject to obtain a first measurement;
receiving, by the computing system, a plurality of types of omics data for the subject;
for each type of omics data, using, by the computing system, at least one classifier associated with the type of omics data to determine whether the subject is in at least one responder category by providing the type of omics data as input to the at least one classifier, wherein the responder category indicates whether the subject is predicted to respond to a particular skincare product ingredient associated with the responder category;
predicting, by the computing system, treatment outcomes for the at least one skin condition for the subject for a plurality of treatments based on the at least one responder category using stored data indicating how a given skincare treatment will affect a given clinical sign of aging for subjects in the at least one responder category;
determining, by the computing system, a skincare regimen based on the predicted treatment outcomes;
measuring, by the computing system, the at least one skin condition for the subject after application of the skincare regimen to obtain a second measurement; and
updating, by the computing system, the at least one classifier based on a difference between the first measurement and the second measurement.

17. The non-transitory computer-readable medium of claim 16 , wherein the types of o

Assignees

• Oreal

Inventors

• Gadol Sandrine
• Rathman-Josserand Michelle
• Askenazi Benjamin
• Bokaris Panagiotis-Alexandros
• Cavusoglu Nukhet
• Nouveau Stephanie

Classifications

• A61B5/441 Primary

  Skin evaluation, e.g. for skin disorder diagnosis · CPC title

• G16H50/20 Primary

  for computer-aided diagnosis, e.g. based on medical expert systems · CPC title

• A61B5/7275

  Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor · CPC title

• A61B5/7264 Primary

  Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems · CPC title