Classifying neurological disease status using deep learning

Patent metadata

Field	Value
Publication number	US-12400321-B2
Application number	US-202117514260-A
Country	US
Kind code	B2
Filing date	Oct 29, 2021
Priority date	Apr 30, 2019
Publication date	Aug 26, 2025
Grant date	Aug 26, 2025

Abstract

A method for classifying neurological disease status is described. The method includes acquiring, by a data preprocessor logic, patient image data. The method further includes generating, by a trained artificial neural network (ANN), a classification output based, at least in part, on the patient image data. The classification output corresponds to a neurological disease status of the patient. The trained ANN is trained based, at least in part, on longitudinal source data.

First claim

What is claimed is:

1. A method for classifying a neurological disease status, comprising:
acquiring, by a data preprocessor logic configuration, patient image data;
electronically preventing overfitting by an artificial neural network (ANN) by enriching the patient image data through an inclusion of a plurality of transformations of the patient image data, the plurality of transformations including longitudinal source data comprising a time series of image data for a patient;
training the ANN on the enriched patient image data, the training comprising:
inputting a training data set from the enriched patient image data;
generating an output score based on the training data set;
comparing the output score to a corresponding cognitive status indicator; and
upon a determination that a loss function for the output score does not meet a target threshold, adjusting at least one ANN parameter based on the comparison; and

generating, by the trained ANN, a classification output based, at least in part, on testing data from the patient image data, the classification output corresponding to a neurological disease status of the patient.

2. The method of claim 1 , further comprising preprocessing, by the data preprocessor logic configuration, the patient image data to yield input image data, the classification output generated based, at least in part, on the input image data.

3. The method of claim 1 , further comprising identifying, by a localization logic configuration, a most predictive image region based, at least in part, on an ANN parameter associated with the trained ANN.

4. The method of claim 1 , wherein the longitudinal source data comprises a plurality of source image data sets from same selected patient, wherein the longitudinal source data is partitioned into training data, validation data and test data, and wherein the partitioning occurs at a level of the same selected patient.

5. The method of claim 1 , wherein the image data comprises at least one of magnetic resonance imaging (MRI) image data, MRI T1-weighted image data, MRI T2-weighted image data, computed tomography (CT) image data, cerebral blood volume (CBV) image data, cerebral blood flow (CBF) image data, mean transit time (MTT) image data, positron emission tomography (PET) image data, or single-photon emission computerized tomography (SPECT) image data.

6. The method of claim 1 , wherein the neurological comprises neurodegenerative diseases and non-neurodegenerative diseases, wherein each neurodegenerative disease comprises at least one of Alzheimer's disease, amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) or Parkinson's disease, and wherein each of the non-neurodegenerative diseases comprises cerebrovascular disease, epilepsy, or stroke.

7. The method of claim 1 , wherein the neurological disease corresponds to Alzheimer's disease and the classification output is comprises at least one of Alzheimer's disease (AD), prodromal AD, mild cognitive impairment (MCI) or cognitively normal (CN).

8. The method of claim 1 , wherein the ANN is comprises at least one of CNN (convolutional neural network), VGGNet (Visual Geometry Group neural network), ResNet (residual network), or DenseNet (densely connected convolutional networks).

9. The method of claim 1 , wherein the ANN is a three-dimensional convolutional neural network (3D CNN), wherein the 3D CNN comprises a number, N, CNN stages coupled in series, wherein each of the CNN stages comprises a first 3D convolutional layer, a second 3D convolutional layer, a batch normalization layer, an activation layer, and a pooling layer, coupled in series, and wherein the 3D CNN further comprises a flattening layer, a fully connected layer and a sigmoid activation function layer.

10. The method of claim 1 , further comprising,
identifying, by the trained ANN, a most predictive region in the patient image data, wherein the generated classification output is based on the identified most predictive region.

11. The method of claim 1 , wherein the patient image data comprise 3-dimensional volumetric digital image data.

12. A neurological disease classifier system, comprising:
a data preprocessor logic configuration configured to acquire patient image data; and
a training system configured to:
electronically preventing overfitting by an artificial neural network (ANN) by enriching the patient image data through an inclusion of a plurality of transformations of the patient image data, the plurality of transformations including longitudinal source data comprising a time series of image data for a patient;
train the ANN on the enriched patient image data, the training comprising:
inputting a training data set from the enriched patient image data;
generating an output score based on the training data set;
comparing the output score to a corresponding cognitive status indicator; and
upon a determination that a loss function for the output score does not meet a target threshold, adjusting at least one ANN parameter based on the comparison; and

generate by the trained ANN, a classification output based, at least in part, on testing data from the patient image data, the classification output corresponding to a neurological disease status of the patient.

13. The system of claim 12 , wherein the data preprocessor logic configuration is further configured to preprocess the patient image data to yield input image data and the classification output is generated based, at least in part, on the input image data.

14. The system of claim 12 , further comprising a localization logic configuration configured to identify a most predictive image region based, at least in part, on an ANN parameter associated with the trained ANN.

15. The system of claim 12 , wherein the longitudinal source data comprises a plurality of source image data sets from same selected patient, wherein the longitudinal source data is partitioned into training data, validation and test data, and wherein the partitioning occurs at a level of the same selected patient.

16. The system according to claim 12 , wherein the image data is comprises at least one of magnetic resonance imaging (MRI) image data, MRI T1-weighted image data, MRI T2-weighted image data, computed tomography (CT) image data, cerebral blood volume (CBV) image data, cerebral blood flow (CBF) image data, mean transit time (MTT) image data, positron emission tomography (PET) image data, or single-photon emission computerized tomography (SPECT) image data.

17. The system according to claim 12 , wherein the neurological disease comprises neurodegenerative diseases and non-neurodegenerative diseases, wherein each neurodegenerative disease comprises at least one of Alzheimer's disease, amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) or Parkinson's disease, and wherein each of the non-neurodegenerative diseases comprises cerebrovascular disease, epilepsy, or stroke.

18. The system according to claim 12 , wherein the neurological disease corresponds to Alzheimer's disease and the classification output is comprises at least one of Alzheimer's disease (AD), prodromal AD, mild cognitive impairment (MCI) or cognitively normal (CN).

19. The system according to claim 12 , wherein the ANN is comprises at least one of CNN (convolutional neural network), VGGNet (Visual Geometry Group neural network), ResNet (residual network), or DenseNet (densely connected convolutional networks).

20. The system according to claim 12 , wherein the ANN is a three-dimensional convolutional neura

Assignees

• Univ Columbia

Inventors

• Feng Xinyang
• Provenzano Frank
• Small Scott A

Classifications

• G06T2207/20084

  Artificial neural networks [ANN] · CPC title

• G06F18/24

  Classification techniques · CPC title

• A61B5/0042

  for the brain · CPC title

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• A61B5/7267

  involving training the classification device · CPC title