Nanomolar peptides and derivatives to differentially modulate ephrin receptors

Patent metadata

Field	Value
Publication number	US-12398179-B2
Application number	US-202017438824-A
Country	US
Kind code	B2
Filing date	Mar 13, 2020
Priority date	Mar 14, 2019
Publication date	Aug 26, 2025
Grant date	Aug 26, 2025

Abstract

Disclosed herein are methods and compositions engineered to modulate EphA2, including novel peptides with unexpectedly high specificity and binding affinity. The compositions described herein can be attenuated to treat subjects suffering from diseases and/or conditions.

First claim

What is claimed is:

1. A composition comprising a peptide comprising β-A-X1-A-Y-P-D-S-V-P-X2 (SEQ ID NO: 1), wherein
X1 is W-L; and
X2 is any one of M-M-S, Mam, Yam, Y-K, Y-S-K, Y-G-S-K (SEQ ID NO: 2), Y-G-S-G-K (SEQ ID NO: 3), Y-R, or Y-S.

2. The composition of claim 1 , wherein the peptide further comprises biotin on a carboxyl terminus (“C-terminal”).

3. The composition of claim 1 , wherein X2 is Y-R.

4. The composition of claim 3 , wherein the peptide further comprises biotin on a carboxyl terminus (“C-terminal”).

5. The composition of claim 1 , wherein X2 is Mam, Yam, Y-K, Y-S-K, Y-G-S-K (SEQ ID NO: 2), Y-G-S-G-K (SEQ ID NO: 3), Y-R, or Y-S.

Assignees

• Sanford Burnham Prebys Medical Discovery Inst

Inventors

• Pasquale Elena B

Classifications

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• A61K47/56

  the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule · CPC title

• A61K38/10

  Peptides having 12 to 20 amino acids {(A61K38/043 - A61K38/046 take precedence)} · CPC title

• C07K14/715

  for cytokines; for lymphokines; for interferons · CPC title

• A61K38/08

  Peptides having 5 to 11 amino acids {(A61K38/043 - A61K38/046 take precedence)} · CPC title